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Biomedical subjects

G F Fueger

Publications and source records attributed to G F Fueger.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Measurement of inner ear circulation using radioactive indicators].

To clarify the possibility of measuring the inner ear blood flow by radionuclide imaging, we used a skull phantom and a scintillation camera and found that a concentration difference of at least 100: 1 between the inner ear and the background is needed for external detection. Similar concentration differences can be found in aminoglycosid antibiotics because of their special pharmacokinetic characteristics. We believe, therefore, that with an appropriate radioactive indicator, such as labelled aminoglycoside or labelled (99mTc, 123J)-inulin, it would be possible to measure the inner ear blood flow in a non-invasive and selective way.

Ear, Inner↗
PubMed1983

[Changes in thyroxine conversion (low T3 syndrome) in children at the time of their first manifestation of type I diabetes].

Measurements of T4, T3, rT3, and TSH were done in 27 children with newly diagnosed type I diabetes mellitus prior to institution of treatment. Serum T4 concentrations were low in 18%, serum T3 concentrations were low in 37%. Serum rT3 concentrations were elevated in 59%; the ratio rT3/T3 was elevated in 78%. The ratio rT3/T3 was significantly higher in the group of patients with the low pH, the low bicarbonate levels, the high blood glucose, and the high serum osmolality values than in the group of patients with the high pH, the high bicarbonate levels, the low blood glucose, and the low serum osmolality values.

Adolescent↗
PubMed1982

Osteoscintimetry--a method of semiquantitative evaluation of skeletal scintigrams by use of profiles and a macro function for computer processing.

A computer macro-program was developed for standardized, semiquantitative measurement of radiotracer uptake. The method uses profiles of selectable length, width, and inclination according to the anatomical structures of the pathological and the corresponding healthy region. The ratio of the two curves is calculated automatically and shown as an 'uptake curve'. The essential use of osteoscintimetry is in the follow-up examination if small changes of regional uptake have to be identified. The profile-technique rather than the ROI-technique was selected, because the main benefit of the profile-technique is that the results of follow-up examinations are comparable to previous examinations with a standard deviation of +/-5%.

Adolescent↗
PubMed1982

[A computer macro-programme for osteoscintimetry and activity profile in Perthe's disease (author's transl)].

A computer macro-programme has been developed which permits quantitative scintigraphy by means of an activity profile. The slope and width of the profile are variable; a view at right angles to the epiphyseal plate of the femoral head is able to determine activity in the plate and in the epiphysis. Measurements of the abnormal and normal hip produce uptake rates. These indicate to what extent the abnormal femoral head and epiphyseal plate differ from the normal side, with respect to their uptake. The method and results are discussed.

Child↗
PubMed1979

[The value of scintigraphy and osteoscintimetry for the early detection of legg-calvé-perthes disease (author's transl)].

Scintigraphy and the stimultaneously effected osteoscintimetry of the pelvis and of both hip joints offers the possibility of a safe early diagnosis of Perthes' disease directly after manifestation of the clinical symptoms, two months before the roentgenologically identifiable, discrete changes of stage I have occurred, or four months before the clear roentgenological visualisation of the disease (stage II). Moreover, scintigraphy enables detection of the time at which restitution or revascularisation of the necrotic bone of the epiphysis of the head of the femur sets in, and to draw further conclusions from the scintigraphic and scintimetric pattern of results, on the prognosis and further course (with time) of Perthes' disease.

Child↗
PubMed1978

Radiological detection of glioblastoma recurrence.

Brain scanning is of great value in detecting glioblastomas. Since there is little stress upon the patient by this method it is specially suitable for follow-up after surgical treatment and radiation therapy of this tumour, thus giving the best chance of an early detection of a recurrence. On the other hand angiography is essential if further surgery is necessary. Diagnostic problems may arise when using arteriography in cases of avascular recurrences and lack of space-occupying symptoms due to the following factors: Position and small size of the recurrence, growth into the operation cavity, and postoperative cerebral atrophy. Avascular mass lesions of other origin may mimic a tumour recurrence in the angiogram. Thus, a combined use of isotope studies and radiological investigations is necessary for an unequivocal detection of glioblastoma recurrences.

Brain Neoplasms↗
PubMed1978

[Modified biological behaviour of 99mTc-pertechnetate in man as a result of a preceeding administration of tin (tin effect) (author's transl)].

An increased image of blood-filled spaces (Plexus choriodeus, Sinus transversus) was observed in 99mTc-pertechnetate scintigraphy when it had been preceded by the administration of tin (e.g. of 99mTc-Sn-diphosphonate). We have called this behaviour the "tin effect". In vitro studies demonstrated binding of about 80% of the administered activity in the blood with a biological half-life of about 44 hr and an effective half-life of about 5.3 hr. 95% of the blood activity was bound to red cells and 5% to plasma. This resulted in an increased radiation dose to the bone marrow of about 530 mrad/mCi 99mTc-pertechnetate (following tin). The extent of the tin effect decreased with the length of the interval between tin and 99mTc-pertechnetate administration. Because of the tin effect 99mTc-DTPA or 99mTc-citrate should be used for brain scintigraphy if this has to be performed within the first 5 or 7 days following a bone scintigraphy with a tin-containing radiopharmaceutical. The "tin effect" might be taken advantages of when labelling red cells and imaging vascular spaces.

Brain↗
PubMed1977

[Comparison of brain scintigraphy with 99mTc-pertechnate and 99mTc-citrate].

20 patients with ultimately proven cerebral lesion were studied consecutively with 99mTc-pertechnetate and 99mTc-citrate. A comparison of the brain scans showed neoplastic lesions to be visualized more clearly with 99mTc-citrate, and vascular lesions to be demonstrated better with 99mTc-pertechnetate. Comparative brain scanning utilizing 99mTc-citrate and 99mTc-pertechnetate facilitates the differentiation between acute brain infarcts and neoplastic lesions which is difficult or may be impossible by cerebral computer tomography. The reduced radiation exposure from 99mTc-citrate and its superior usefulness in the visualization of neoplastic lesions suggest its use as the primary brain scanning agent.

Brain Diseases↗
PubMed1977

[Relative uptake of 99mTc-diphosphate and its temporal change in bone diseases].

Quantitative regional measurements of the distribution of a bone seeking radiopharmaceutical is performed easily together with a bone scan using a scintillation camera. Comparative measurements of regional radioactivities yield a ratio of relative uptake. The time change of such a relative uptake ratio is obtained by repeating the regional comparison measurements after a 4--8 weeks interval. The time change of the relative uptake ratio was found to be a clinically useful parameter in the follow-up of skeletal diseases. A decrease in the relative uptake ratio was found with healing fractures, with receding osteomyelitis and during radiation therapy of bone metastases; an increase was observed with spreading metastases, developing osteomyelitis, developing pseudathrosis, and in the beginning of normal fracture healing.

Bone Diseases↗
PubMed1976

[A prospective study on the occurrence of postoperative thrombosis of leg-veins and the possible influence of aescin in its prevention (author's transl)].

Based on the frequency of subclinical, postoperative thrombosis which we detected using radio-iodine-tagged fibrinogen (125I-fibrinogen) in 2 comparable test groups of 100 female patients each, we were able to compare the effectiveness of Aescin (Reparil) to the untreated group. Whereas only 16 patients in the Reparil group were thrombose-positive we found 27 such cases in the control group. The analysis of these data shows Reparil to be of distinct advantage when compared to the untreated group.

Adolescent↗