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Biomedical subjects

G F Lombard

Publications and source records attributed to G F Lombard.

At least 19 recordsLinked to original sources
PubMed1992

[Statistical comparison of surgical results with or without laser in neurosurgery].

In the literature, no significant statistical studies have been published on the effectiveness of laser compared with traditional procedures in neurosurgery; we have decided to study a series of 198 gliomas and 220 meningiomas operated upon either with a laser or with conventional techniques. We considered the post-operative morbidity, the duration and the quality of survival. These data have been clearly influenced by the type of surgery. On the contrary, no significative difference was observed concerning the survival rate of gliomas whatever their grading. In the laser-group, morbidity and quality of life are improved (36 months follow-up); but the mortality rate (3 years) is equal in both groups. Concerning meningiomas, patients of both groups (with and without laser) were clinically improved during the post-operative period. A significative difference appears only for meningiomas located in functional areas and operated with a laser.

Brain Neoplasms↗
PubMed1992

[Postoperative neurosurgical complications in brain tumors operated in the elderly].

200 patients of geriatric age, operated on for cerebral neoplasm, have been studied in order to estimate the most important factors influencing the post-operative course. We have considered the "Volume of the tumour", the "Pre-operative and at-discharge Karnofsky Score", the possible "Pre-existent pathologies" and the checked "Post-operative complications". As a conclusion we have considered relevant over the final outcome the following factors: a) the presence of general pre-existent pathologies, first of all diabetes and hypertension; b) the volume, more than the site and nature, of the neoplasm subject of the operation; c) the nature and the importance of local post-operative complications.

Aged↗
PubMed1989

[Common problems for the neurosurgeon and the anesthesiologist in pediatric neurosurgery].

In pediatric neurosurgery the cooperation between neurosurgeon and anaesthesist is very tight. It begins with the clinical evaluation of preoperative conditions (weight, trophism, age, etc.), then continues with the through preparation of the operative position of the little patient and with the control of unfavourable side-effects of some particular positions (intraoperative air embolism in the sitting position, postoperative tension pneumocephalus). At last this cooperation is very important to analyse the vital functions and the neurological picture in the immediate postoperative period.

Adolescent↗
PubMed1986

Bactericidal effects induced by laser irradiation and haematoporphyrin against gram-positive and gram-negative microorganisms.

Laser irradiation of tissues treated in vivo with haematoporphyrin (Hpr) is known to result in a cytocidal effect, reportedly more pronounced in tumour tissues. To ascertain whether this cytocidal phenomenon can occur not only in eukaryotic but also in prokaryotic cells, the authors devised a model system in vitro consisting of bacterial cultures in liquid and in solid media. Bacteria photosensitized with Hpr were subsequently exposed to laser beams and to daylight; then normal microbiological techniques were used to determine whether any bactericidal effect occurred. Satisfactory results were achieved, particularly against Gram-positive microorganisms; a partial inhibition of Gram-negative microorganisms was also observed.

Culture Media↗
PubMed1984

Treatment of cerebral arterio-venous malformations with laser.

The surgical application of the laser in the treatment of vascular diseases of the brain is based on its characteristic to perform an immediate or delayed modification of the vessel wall either by shrinking the collagenous fibres or by intraluminal thrombosis. Personal researches have been carried out to study the histological modifications of the vessel wall in normal arteries following laser irradiation with Nd:YAG. On this basis we have treated arterio-venous malformations (AVMs) in man. The laser enables radical surgery with a complete preservation of the healthy tissue surrounding the lesion because of reduced manipulation and the absence of intraoperative haemorrhage. Doppler technique and real-time ultrasonography are mostly suitable in the identification of the small deep-seated AVMs localizing the site of the malformation and the reactive glial tissue surrounding the lesion. The main indications are small AVMs located in critical areas of the brain.

Adult↗
PubMed1983

Preliminary experiences with the use of three lasers (CO2, Nd: YAG, Argon) in some posterior fossa tumors in childhood.

The authors present 5 cases of posterior fossa tumors in childhood operated on using three laser sources: CO2, Nd: YAG and Argon. Each laser source is used as required during the different steps of the operation: CO2 for cutting and vaporizing, Nd: YAG for shrinking the tumoral mass and deep coagulation and Argon for selective cutting and superficial coagulation of small vessels. The main advantages of multiple laser surgery are: (1) a more radical surgery with less side effects (edema); (2) the possibility of operating near high functional structures with great accuracy, and (3) reduction of blood loss.

Adolescent↗