[Effect of biliary stasis on lipid peroxidation and bile composition in in vitro experiment].
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Biomedical subjects
Publications and source records attributed to G F Luk'ianchikov.
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A new method for the assessment of lipid peroxidation permits simultaneous assays of total lipids and formed malonic dialdehyde in the examined chloroform substrate; this will help define the criteria of cellular membrane destruction in various biological media of the body.
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With a new technique for the assessment of lipid peroxidation products in chloroform bile extracts it was possible to register an increase in the ratio malonic dialdehyde/phospholipids in patients with both calculous and acalculous cholecystitis. Bile of all patients with acute cholecystitis was characterized by a decrease in concentration of all the components, but use of relative parameters (malonic dialdehyde/phospholipids, index of bilirubin fractions and cholesterol/lecithin index) allows to verify the stage of the inflammation. The changes were unidirectional in B-bile and C-bile portions in all the patients with acalculous cholecystitis.