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Biomedical subjects

G F Ronconi

Publications and source records attributed to G F Ronconi.

At least 19 recordsLinked to original sources

[Therapy with high-dose intravenous gamma globulin in the newborn infant with thrombocytopenia from passive immunization].

High doses of gammaglobulin intravenously have been found useful in controlling thrombocytopenia of a neonate born to a mother who developed acute idiopathic thrombocytopenic purpura during pregnancy. Administration of 0.4 gm/kg/day of intact gammaglobulin intravenously for five days was followed by dramatic rise of platelet count without any side-effect. After 1 month the platelet count was still normal. Passively-acquired immune thrombocytopenia of the newborn consequently is another indication for intravenous gammaglobulin therapy.

Humans↗

[Care of the newborn infant with respiratory distress syndrome using continuous negative pressure. 5 years' experience].

Continuous Negative Pressure (CNP) was utilized as sole form of respiratory assistance in the treatment of 40 newborn infants with Respiratory Distress Syndrome (RDS). The average duration of CNP therapy was less than 7 days in all cases. 38 of these infants survived without sequelae (95%); an infant developed severe bronchopulmonary dysplasia (2.5%); another infant died from intracranial hemorrhage (2.5%). CNP appears to be an effective respiratory support in the treatment of neonatal RDS, when used early in spontaneously breathing infants weighing greater than 1500 grams.

Bronchial Diseases↗

[Bronchopulmonary dysplasia after treatment with continuous negative pressure].

Bronchopulmonary Dysplasia (BPD) rarely occurs in newborn infants with RDS ventilated using CNP devices. In this paper we describe a case of BPD following respiratory therapy with CNP in a preterm baby affected by hyaline membrane disease (HMD). Probably the rarity of BPD after CNP treatment is related either to less severe HMD in newborns weighing less than 1500 g, or to the low diffusion of CNP respirators in Neonatal Care Centers.

Bronchial Diseases↗

[Sympathomimetic drugs in the newborn infant].

In newborn infants with compromised clinical conditions, it is frequently necessary to improve the perfusion of the vital organs, and the choice often falls on sympathomimetic drugs. However their appropriate use is still discussed and the difference of the opinions about their choice is partially due to scarcity of controlled clinical studies. The purpose of this study is to supply, on the basis of the present knowledges, the opportunity of a rational choice and use of the sympathomimetic drugs in the neonate. The Authors consider the development of the cardiovascular sympathetic innervation and the different responsiveness to sympathomimetic drugs of the human foetus, compared to those of the animal foetuses. Then they discuss the pharmacological characteristics of some of the most important sympathomimetic drugs: adrenaline, isoproterenol, dopamine, dobutamine, indicating choice, and clinical use of them.

Autonomic Nervous System↗

[Neurogenic hypernatremia with adipsia and cerebral malformations in a child with ectrodactyly-ectodermal dysplasia-cleft lip-palate syndrome].

An infant with E.E.C. Syndrome (a genetic condition characterized by: Ectrodactyly, Ectodermal dysplasia, Cleft Lip-Palate) and delayed psychomotor development was found to have chronic hypernatremia and absence of thirst. Computerized brain tomography revealed abnormal lateral ventricles, agenesis of corpus callosum, calcified cortex. His plasma Anti Diuretic Hormone (ADH) levels were inappropriately low relative to his high values of plasma osmolality, whereas ADH responsiveness to nonosmotic stimuli was normal. E.E.C. Syndrome in this baby is characterized by: ectrodactyly of the feet, syndactyly of the 3rd and 4th finger of the hands, bilateral cleft lip and cleft palate, bilateral microtia, lacrimal ductular stenosis. To our knowledge, this is the first report of a case of chronic hypernatremia in conjunction with normal ADH stores, congenital abnormalities of brain structures, and E.E.C. syndrome.

Abnormalities, Multiple↗

[Influence of the modality of delivery on the plasma levels of ADH in the mother and the newborn infant].

We have studied plasma levels of Anti Diuretic Hormone (ADH) and its relationship to mode of delivery in 21 mothers and in their newborns. On the basis of the mode of delivery, mothers were divided into three subgroups: vaginal delivery before administration of oxytocin; vaginal delivery after administration of oxytocin; caesarean section. The infants are divided into two subgroups: neonates born by vaginal delivery (14 cases); neonates born by caesarean section (7 cases). ADH levels were determined at birth and in third day of life in the neonates. ADH determination was made by Radioimmunoassay (RIA). A noticeable rise in hormone levels was found in infants born by vaginal delivery, but not in neonates born by caesarean section. In third day of life ADH levels were comparable in all neonates. No significant difference was encountered in ADH levels among the subgroups of mothers. There was no correlation between ADH levels and: maternal age, placental weight, duration of labor, period of gestation of the mothers; neonatal weight, gestational age, body weight in 3rd day of life of the neonates; plasma sodium and osmolality both of the mothers and of the neonates. High levels of ADH in neonates delivered vaginally may contribute to increase the blood flow to the placenta and to other vital structures of the fetus during labour.

Cesarean Section↗

[Effect of phototherapy on the plasma levels of antidiuretic hormone in the newborn infant].

The purpose of this study was to assess the influence of prolonged phototherapy on plasmatic levels of Anti Diuretic Hormone (ADH) in jaundiced newborns. 13 hyperbilirubinemic, otherwise healthy full-term newborns submitted to the phototherapy, were compared to 12 healty, full-term nursery newborns as a control group. No statistical difference was found in ADH levels in 3rd day of life between jaundiced and normal newborns. ADH levels before and after phototherapy do not present any statistical difference, in the jaundiced neonates receiving adequate water and caloric intakes. There was no positive correlation between ADH and bilirubin levels neither in 3rd nor in 5th day of life. Prolonged phototherapy, constant covering of the eyes, deprivation of the day-night rhythm, in absence of gross environmental alterations or of pathological findings, are lacking of effect on the ADH levels in hyperbilirubinemic neonates.

Female↗

[Anomalies of phospho-calcium metabolism during antiepileptic treatment].

It is known that, particularly in Nordic States, many patients undergoing antiepileptic therapy with Phenobarbital and Phentoin present disorders of the phospho-calcium metabolism, both clinical and biochemical. For what concerns the mediterranean area, few are the papers written concerning this subject in these last years. In this paper we attempt to provide a "case study" contribution (100 cases) to enable us to study the above-mentioned alteration focusing on an area half way between Central and Southern Europe. The Authors discuss the possible mechanism implicated in this affection.

Adolescent↗

[Frequency of colonization of beta-hemolytic group B streptococci in a sample of 939 pregnant women. Epidemiologic and clinical study].

A prospective study of group B Streptococcus colonization in 939 pregnant women from Vicenza and its region, disclosed an overall rate of 9.58% of genital colonization. Only two cases of group B streptococcal infant disease occurred in the study period (0.21%). No statistically significant difference between culture-positive and culture-negative pregnant women was found in mean age, parity, place of residence, blood group, presence of clinical disease during pregnancy, type of delivery and gestational age, birth weight and presence of any clinical disease over five days from birth of the newborn infants. The Authors make some recommendations based upon the best understanding of the epidemiology of group B streptococci available at this time.

Female↗

[Duplication of the femur, imperforate anus and polydactyly in a stillborn infant].

An unusual case of stillborn fetus with imperforate anus and left lower limb malformation is described. The principal features were: femoral duplication, muscular atrophy below the knee, heel malformation with absence of calcaneous bone, presence of nine toes of the left foot associated with imperforate anus and with presence of cutaneous tag on the left buttock. No similar case reports are known by the Authors at the present time.

Abnormalities, Multiple↗

[Biofeedback in asthmatic children].

This paper reports the results of the treatment of continuous bronchial asthma in children, 7-14 years old, by means of biofeedback and the counter-conditioning. We observed the remission of the symptomatology in all the cases, with a statistical significance.

Adolescent↗

[Distal renal tubular acidosis with nerve deafness].

The Authors describe a case of renal tubular acidosis (type I or distal type) with neural deafness in a male child. The condition is inherited as an autosomal recessive trait. Addition of NaHCO3 and potassium to diet allowed normal growth without sequelae. Speech development was retarded because of the neurosensorial deafness, partially corrected by hearing aids.

Acidosis, Renal Tubular↗

[Sound alarms and conditioning therapy in the treatment of childhood enuresis: a study of 180 cases].

The Authors present the study and results in 180 cases of infantile enuresis, treated with a new bell alarm associated to conditioning psychological treatment (toilet training, token economy, motivational counseling, urine stop exercises, etc.). The cases have been subdivided into the type of enuresis, age and sex. 140 (77.8%) subjects aged from 6 years to 16 years with primary enuresis, and 40 (22.2%) aged from 6 years to 15 years with secondary enuresis have been treated. The following results were obtained in the primary enuresis with this type of treatment after a follow-up of 6-12 months: permanent recovery in 85.71% of the cases, relapse after 6 months in 11.42%, improvement in 5% and failures in 9,29% of the cases. In secondary enuresis the following results were obtained: permanent recovery after 12 months in 75% of the cases, relapse after 6 months in 10%, improvement in 7.5% and failures in 17.5% of the cases. The differences in the results between the two types of enuresis with respect to the age of the cases up to 12 years are proved and relatively less with respect to the average time of treatment for the total remission. Regarding the sex of the cases no significant therapeutic answer was noted neither in the final results nor in the time of treatment in both types of enuresis. Finally, it is not the substitution of symptoms which are proved but the benefits of a general and psychological level.

Acoustic Stimulation↗

[A case of transient congenital hypoaldosteronism].

A case of temporary congenital hypoaldosteronism with normal production of other hormones of the adrenal is described. During early infancy the patient showed low blood aldosterone levels, increased ACHT and Hyponatraemia. Replacement therapy needed sodium chloride and mineralcorticoid drug administration (Florinef) until the baby was 9 month old. Later, spontaneous recovery occurred, confirmed by laboratory tests.

Aldosterone↗