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Biomedical subjects

G F Ryan

Publications and source records attributed to G F Ryan.

9 recordsLinked to original sources
PubMed1990

Pulmonary toxicity following MOPP chemotherapy.

Pulmonary toxicity is a well recognised side effect of anticancer agents particularly bleomycin, cyclophosphamide, methotrexate, and busulphan. In contrast this problem has been infrequently reported following MOPP (nitrogen mustard, vincristine, prednisolone, procarbazine) chemotherapy for Hodgkin's disease and has been attributed principally to the procarbazine. We report a further instance of MOPP associated pulmonary toxicity. This case and a review of previously published cases indicate that MOPP chemotherapy may be associated with the development of permanent lung damage as well as an acute reversible hypersensitivity lung disease.

Aged↗
PubMed1987

Mortality from asthma in Western Australia.

From a cohort of all 5760 male and 4979 female patients who were admitted to WA hospitals and were discharged with a diagnosis of asthma between 1976 and 1980, 265 deaths in men and 189 deaths in women were identified by the end of 1982. The standardized mortality ratio (SMR) for all causes of death for this cohort was 1.6 for men (P less than 0.001) and 1.7 for women (P less than 0.001). Both sexes showed a significant increase in deaths that were attributable to asthma (SMR, 57.9), chronic airflow obstruction (SMR, 9.3) and ischaemic heart disease (SMR, 1.3). The excess death rates for asthma were observed in all age groups, but those for chronic airflow obstruction and ischaemic heart disease were present in older age groups only. These findings indicate that asthma remains a potentially fatal disease in the Australian community. The excess mortality ratios for chronic airflow obstruction that were observed in patients who were admitted to hospital with asthma also suggest that asthma may result in irreversible airflow obstruction.

Adolescent↗
PubMed1985

Hypoxemia from right to left shunting through patent foramen ovale.

We report a patient with severe hypoxemia from a large (41%) right to left shunt through a patent foramen ovale after right ventricular myocardial infarction, and review 18 previous descriptions of patients with right to left shunting through patent foramen ovale. These shunts occur when right atrial pressure is elevated above left atrial pressure, or when the anatomic relationship of the interatrial septum to the inferior vena cava is altered. Since 15-35% of the population have a potentially patent foramen ovale, interatrial right to left shunting may occur more frequently than had previously been recognized, and should be considered in a differential diagnosis of hypoxemia.

Adult↗
PubMed1979

Bilateral congenital coronary artery--pulmonary artery fistulae: report of two unusual cases.

Congenital coronary arteriovenous fistulae involving both coronary arteries are rare. Those terminating in a right heart chamber or the pulmonary artery usually mimic a patent ductus arteriosus because of the presence of a continuous murmur. Since the vascular resistance is much lower in the pulmonary circuit than in myocardial capillaries, a large percentage of coronary blood flow may be directed through the fistula. Such a "steal" can cause myocardial ischemia distal to the origin of the fistula. Angina has been reported to occur. About 20% of coronary A-V fistulae are associated with other congenital cardiac anomalies.

Coronary Angiography↗
PubMed1976

Field accumulation of aflatoxin in cottonseed as influenced by irrigation termination dates and pink bollworm infestation.

Aflatoxin accumulation in Deltapine 16 cottonseed, grown in Yuma, Ariz., in a 3-year study, was significantly influenced by the timing of irrigation terminations and by level of pink bollworm infestations. In 1971 and 1972, termination of irrigations by early August resulted in significantly less aflatoxin than in plots where two additional irrigations were applied. Significantly less aflatoxin also was found in the 1971 and 1973 plots where low levels of pink bollworm infestations were maintained.

Aflatoxins↗