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Biomedical subjects

G F Wündisch

Publications and source records attributed to G F Wündisch.

8 recordsLinked to original sources
PubMed1978

[Juvenile reticulosarcoma].

The prognosis of malignant lymphoma of bone in childhood has been improved. This is due to the modern chemotherapy. Pain in the bones is one of the early symptoms. If these early symptoms are not recognized, diagnosis and therapy may be delayed. The problems of classification, diagnosis and therapy are discussed, 2 case-reports with so-called reticulum cell sarcoma are given.

Adolescent↗
PubMed1978

[T-cell-antigen positive, E-rosette negative acute lymphoblastic leukaemia (author's transl)].

The lymphoblasts from 100 patients with acute lymphocytic leukaemia were investigated for the expression of receptors for sheep erythrocytes (E) and of a specific heterologous T cell antigen (T). In 17 cases, both T cell markers were expressed simultaneously on the leukaemic cells. In 13 cases only T antigens could be demonstrated on the lymphoblasts. A quantitative analysis of T antigens by immunoautoradiography revealed that the T expression of E-T+ -lymphoblasts was in general like that of E+T+-lymphocytes in the blood of normal persons, in several cases even higher. Therefore, the failure of E-rosette formation cannot be correlated to a decrease of the other T cell differentiation marker. In 7 out of 9 tested cases, a strong acid phosphatase reaction product located paranuclearly could be demonstrated. Complement-receptors were expressed in 3 of 5 cases which were also demonstrated in some cases of the E+T+-ALL group. The latter group was characterized by a T antigen expression like that of thymocytes. 4 cases of the E-T+ALL group were adults. Since the leukaemia cells of 2 cases were negative for acid phosphatase, PAS and all surface markers including cALL antigen, the T antigen can classify undifferentiated and otherwise unclassificable leukaemias. The clinical signigicance of the E-T+-ALL seems to be important since 5 out of 9 children with this type of ALL died soon after diagnosis.

Adult↗
PubMed1977

[Morphological and functional studies in a case of primary (idiopathic) thrombocythaemia in childhood (author's transl)].

Primary (idiopathic) thrombocythaemia is a rare disease in childhood. Haemorrhagic diathesis and splenomegaly are principal findings besides thrombocytosis. The cases of a nine year old girl with thrombocyte levels between 2.8 and 4.5 X 10(6) microliter is described. The examination in light and electron microscopy revealed various morphological abnormalities in thrombocytes and megakaryocytes. Platelet function was disturbed in various degrees. The impact of functional abnormalities on the haemorrhagic diathesis is discussed. The findings in this child were compared to those of the better characterized picture of primary and secondary thrombozytosis in adulthood. Possible pathogenic relations to myeloproliferative diseases are also discussed.

Blood Platelets↗
PubMed1977

[Treatment of aplastic anemia in children by bone marrow transplantation (author's transl)].

The course of a successful bone marrow transplantation in a 8 year old boy with severe aplastic anemia is presented. The boy lives now 22 months after bone marrow transplantation with normal bone marrow function and an essentially undisturbed performance; The indication for bone marrow transplantation for severe aplastic anemia in children is discussed. Despite improved intensive supportive care (antibiotics, infectious prophylaxis, substitution of blood components) and the treatment with corticosteroids and/or androgens the mortality of sever aplastic anemia in childhood is still high. The advantages of early bone marrow transplantation in severe cases are stressed.

Anemia, Aplastic↗
PubMed1975

Bone marrow transplantation in children with aplastic anemia and acute lymphatic leukemia.

A boy with severe Aplastic Anemia (AA) and a girl with Acute Lymphoblastic Leukemia (ALL) in relapse have been grafted with marrow from HL-A identical, mixed leukocyte culture (MLC) negative siblings after appropriate immunosuppressive and antileukemic therapy. Both of them are well 7 and 2 months after transplantation respectively. Bone marrow transplantation should be considered in children with AA and ALL in relapse, if HL-A identical, MLC negative siblings are available.

Anemia, Aplastic↗