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Biomedical subjects

G Fabry

Publications and source records attributed to G Fabry.

At least 19 recordsLinked to original sources
PubMed1998

Conservative treatment of femoral shaft fractures in patients with total hip arthroplasty.

Over a period of 20 years, 34 patients with a total hip arthroplasty were treated conservatively for a femoral shaft fracture. Thirty-five fractures were treated by traction followed by cast-brace or by cast-brace alone. Sound healing was obtained in 33 fractures. Problems were angular malalignment jeopardizing revision surgery in cases of loosening, long hospitalization, and a considerable complication rate. As a consequence, the authors no longer recommend conservative treatment as the first choice for these difficult fractures.

Aged↗
PubMed1998

Treatment of hip subluxation in Dyggve-Melchior-Clausen syndrome.

We report a case of Dyggve-Melchior-Clausen syndrome, a skeletal dysplasia with short trunk dwarfism and mental retardation. A Chiari pelvic osteotomy was performed to halt hip subluxation on both sides. The patient was evaluated after 9 years and 10 months. The progressive lateral migration of the femoral head seemed to have been unaffected by this type of osteotomy.

Abnormalities, Multiple↗
PubMed1998

Characteristics of patients with symbrachydactyly.

The clinical and radiologic spectrum of symbrachydactyly has been extended, on the basis of experimental embryology, into four categories: typical symbrachydactyly, atypical cleft hand, monodactyly, and adactyly. The origin of this embryologic failure is probably a vascular disruption. A series of 64 hands and 3 feet are reported, indicating associated anomalies and possible etiologic features.

Child↗
PubMed1998

Distraction bone healing versus osteotomy healing: a comparative biochemical analysis.

This study investigates the biochemical changes in a canine tibia lengthening model in comparison with a nonlengthened osteotomy model. The lengthened and the osteotomized callus and a contralateral corresponding segment were analyzed for their mineralization profile, collagen content, osteocalcin, insulin-like growth factor I (IGF-I), and transforming growth factor beta1 (TGF-beta1). Examinations of bone samples were performed using specimens excised at different time intervals (respectively at 3, 5, 7, 9, and 13 weeks postoperatively). Several serum parameters (alkaline phosphatase [ALP], osteocalcin, IGF-I, and TGF-beta1) were also measured during the experimental period. A progressive increase in mineral parameters was noticed in both the lengthened and the osteotomized areas. A higher level of hydroxyproline and TGF-beta1 was observed in the lengthened area compared with the osteotomized area. IGF-I showed a significant increase in both the lengthened and contralateral control area at the later stage of the experimental period in the lengthened group. In serum, a high level of TGF-beta1 and a progressively increasing osteocalcin concentration were observed in the lengthened dogs in comparison with the osteotomized dogs. Serum ALP was significantly increased in both models during the experimental period. Serum IGF-I was increased in the lengthened models during the distraction period and decreased in the osteotomized models at the early stage of the experimental period. These results suggest that the mechanical strain induced by the Ilizarov distraction procedure stimulates osteoblast proliferation and promotes biosynthesis of bone extracellular matrix in distracted callus. Our data furthermore show that this process is different compared with normal fracture healing.

Alkaline Phosphatase↗
PubMed1998

Symbrachydactyly involving hands and feet.

Two patients are described with a symbrachydactyly of the hand and foot. This is a rare combination which cannot be explained by the subclavian artery supply disruption sequence.

Abnormalities, Multiple↗
PubMed1998

Grip strength in tennis elbow : long-term results of operative treatment.

In a prospective study the grip strength was measured preoperatively in 17 patients with chronic tennis elbow and postoperatively after a minimum follow-up of 1 year. The grip strength measured with a flexed and extended elbow was significantly less on the involved side (28.4 and 17.2 kg) than on the normal side (36.4 and 36.5 kg) ; postoperatively it increased significantly (33.9 and 34.2 kg) and almost reached the level of the normal contralateral side. An increase of grip strength measured with an extended elbow was correlated significantly with a satisfactory clinical outcome.

Adult↗
PubMed1998

Popliteal cysts in children: a retrospective study of 62 cases.

Popliteal cysts in children are usually asymptomatic and are usually found fortuitously by the parents. This study presents a series of 62 children with popliteal cysts. Among the 51 patients who received no treatment, the cysts had already disappeared at the time of the study in 43 patients; the remaining 8 patients are under 14 years of age and are without complaints. This study confirms the hypothesis that the primary popliteal cyst in children usually disappears before the age of 18. Surgery presents unnecessary risks for the patient ; moreover, the chance of recurrence after surgery is real.

Adolescent↗
PubMed1998

Ganglia of the superior tibiofibular joint: report of three cases and review of the literature.

Ganglion cysts that compress the common peroneal nerve frequently arise from the proximal tibiofibular joint. We report three cases of such ganglia. In one case the ganglion cyst arises from the proximal tibiofibular joint, finds its course along the common peroneal nerve causing pain, but no neurological deficit. In the two other cases the cysts have the same origin but they are the cause of a progressive peroneal nerve palsy. Treatment in these three cases was successful resection of the cyst with non mutilating surgery for the nerve and ligation of the stalk connecting the ganglion to the proximal tibiofibular articulation. A review of the controversial pathogenesis of the intra- and extraneural ganglia is exposed, and the anatomy, the diagnosis, the surgical treatment and the prognosis is discussed in light of relevant literature.

Adult↗
PubMed1997

Biochemical and density assessment of the new bone in late remodeling after callus distraction.

Biochemical changes in a canine bone-lengthening model were characterized 5 months after surgery. The mineral content and the total amount of EDTA-extractable noncollagenous proteins, insulin-like growth factor-I, and osteocalcin were determined for the lengthened callus, and a gradient density fractionation analysis of bone powder particles was performed. The results were compared with two other areas of the lengthened tibia and one region of the contralateral tibia. The mineral and osteocalcin contents showed significant decreases, whereas the hydroxyproline concentration was significantly increased. Neither the insulin-like growth factor-I content nor the concentration of EDTA-extractable proteins was significantly different in any of the examined regions.

Animals↗
PubMed1997

Simple trapezectomy for treatment of trapeziometacarpal osteoarthritis of the thumb.

This is a review of 20 patients (22 operations) with symptomatic osteoarthritis of the first carpometacarpal joint who were treated by simple trapezectomy without interposition material. They were all women with a mean age of 60 years (46-77). The average follow-up was 2 years, ranging from 8 months to 3 years. Pain relief is the main contributor to the good clinical results of this procedure. Sixteen patients professed to be very satisfied, two had a fair result and four cases claimed to be unsatisfied. Range of motion (opposition and counter opposition) and first web space were very well preserved. Mean values of grip strength showed reduction of grip power on the operated side though not statistically. However, we did find a statistically significant difference in pinch strength between operated and non-operated side. In general, simple trapezectomy is our preferred surgical therapy in the treatment of carpometacarpal osteoarthritis in the elderly population.

Aged↗
PubMed1997

Graft selection in anterior cruciate ligament reconstruction--prospective analysis of patellar tendon autografts compared with allografts.

A prospective study of 73 arthroscopic anterior cruciate ligament reconstructions using either a patellar tendon autograft or an allograft was made to assess any difference in clinical outcome. Allocation was by availability of an allograft. There were 48 autografts and 25 allografts. Evaluation was by clinical examination and physical tests. At follow-up 2 years after operation, there were no statistically significant differences between the two groups in mobility or in physical tests, but KT-1000 evaluation showed a slightly greater anterior translation in the autografts at 6 months and one year, although at 2 years the allografts developed greater anterior laxity. Cybex testing showed greater quadriceps strength at 6 months and one year in the allografts, but at 2 years the strength was greater in the autografts. Re-rupture occurred in 3 allografts. ACL reconstruction with a patellar tendon allograft does not produce a significant functional deficit. Full quadriceps recovery takes 2 years. Allografts are not recommended as stability deteriorates with time.

Adolescent↗
PubMed1997

Pedodynographic measurements after forefoot reconstruction in rheumatoid arthritis patients.

From January 1987 to December 1992, 38 patients (59 feet) with rheumatoid arthritis underwent reconstruction of the forefoot using Keller-Lelièvre arthroplasty of the first metatarsophalangeal joint and Hoffman resection of the lesser metatarsal heads. The average age of the patients was 61.3 years, with both feet involved in 21 patients and 17 with single foot involvement. The aim of our study was to evaluate the results both on a functional and an objective basis using dynamic and static pedodynographic measurements. Attention was given to dynamic pressure measurements under the metatarsal heads, the center of pressure distribution, gait analysis, and peak loads taken on different areas of the forefoot during normal walking. Correlations were made between these measurements and symptoms. After a mean follow-up time of 35 months, the clinical results were satisfactory in 54%, satisfactory with some reservations in 39%, satisfactory with major reservations in 3%, and unsatisfactory in 3% of patients.

Adult↗
PubMed1997

Proximal row carpectomy: an alternative to wrist fusion?

Problems with implant failure and silicone synovitis and a high complication rate in wrist arthrodesis have recently increased the interest in solutions that use residual biological articular surfaces. These include limited intercarpal fusions and proximal row carpectomy (PRC). PRC is a relatively easy procedure with few complications. We reviewed 27 personal cases. According to this study PRC offers a painless range of motion, with an average of 68 degrees flexion/extension range and an average grip strength of 60% of the contralateral side. The failure rate is 18.5%. However, failures can be successfully converted into wrist arthrodesis. Our follow-up period ranges from 6 to 36 months. Late deterioration has not been reported in the literature. On the contrary, improvement of mobility and grip strength several months after operation have been observed. We still favor PRC as a salvage procedure in order to offer the patient some motion, provided that there is no osteoarthritis over the capitate and the lunate facet preoperatively.

Adult↗
PubMed1997

Psoas and adductor release in children with cerebral palsy.

In a retrospective study of 12 cerebral palsy patients with 17 hips treated for subluxation, clinical and radiographic results of psoas and adductor releases were reviewed. With an average follow-up of 4.05 years, the functional ability was improved in 3 spastic quadriplegics and 3 diplegics and maintained in 6 other patients. The CE-angle and femoral head coverage did not change significantly. The AC-index improved significantly (p = 0.01).

Adolescent↗