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Biomedical subjects

G Falzi

Publications and source records attributed to G Falzi.

At least 19 recordsLinked to original sources
PubMed1987

Liver histopathology in autopsied drug-addicts.

Liver specimens of 150 randomly selected autopsied drug addicts from the province of Milan (Italy) were studied using light microscopy, polarized light and immunohistochemical methods. Simple histological changes and the main diagnoses are described. The main histological diagnoses in order of frequency were: non-specific reactive hepatitis (NSRH) (52%), chronic aggressive hepatitis (CAH) (24%), acute hepatitis (AH) (12%), normal liver (6%), steatosis only (3.3%) and cirrhosis (2%). In 24 cases (16%) one or more viral antigens (HBsAg, HBcAg and Delta Ag) were detected in hepatocytes by immunohistochemical methods. Three liver specimens revealed epithelioid cell granulomas, but in no case was birefringent material identified in the liver. AH and CAH were more frequent in the group of livers with viral antigens. Our histological and immunohistochemical data confirm the current opinion that, in most cases, liver pathology in drug addicts has a viral aetiology, while no significant pathogenic role has been identified for drugs, alcohol or contaminants. Recurrent infections by one or several viruses possibly explain the relatively peculiar histological features of hepatitis in drug addicts.

Adult↗
PubMed1982

Right-left asymmetry in anterior speech region.

The extent of the anterior speech region (defined as pars opercularis and pars triangularis of the third frontal convolution) and of the planum temporale was measured in 12 brains belonging to strictly right-handed persons. When the portion of the anterior speech region visible on the hemispheric surface was measured, no interhemispheric difference was found. By contrast, when both the extrasulcal and intrasulcal portions of cortex were considered, the anterior speech region in the left hemisphere was found to be significantly larger than the homologous areas in the right hemisphere. The planum temporale was significantly larger on the left than on the right, but there was no necessary correspondence between the presence of a larger right planum and a larger right anterior speech region.

Cerebral Cortex↗
PubMed1980

[Morphology, frequency and significance of intramural arterial lesions in sudden coronary death (author's transl)].

In 208 selected cases of sudden coronary death (SD) and in 97 normal subjects dying from accident (AD) the intramural arterial vessels have been studied. In only one instance a unique "atheromatous" embolus was found. Arterial platelet aggregates (AP) were seen in 70% of SD and 76% of AD cases. The average number of arteria vessels with AP per section was 2.2 in SD and 2.5 in AD group (the range was 1 to 15 vessels). No correlation was found with the type of blood stasis and with a longer survival time. The conclusion is that AP are a secondary, terminal, non pathogenic phenomenon. This was documented by the findings in 39 cases of thrombotic thrombocytopenic purpura. In the latter, despite severe platelet sequestration and aggregation associated to other severely ischemic or hypoxic factors (obstructive microangiopathy, anemia, hemorrhagic diathesis, convulsive neurologic disorders) no evidence of coronary heart disease was shown. Other pathologic findings were "stenosing myo-fibrous medial hyperplasia" and more rarely intimal thickening, perivascular fibrosis and subintimal nodular hyalinosis. No one of these conditions predominated in SD cases. The conclusion is that the diseases of the small coronary arteries do not play any role in the nautral history of sudden coronary death.

Coronary Disease↗