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Biomedical subjects

G Fantuzzi

Publications and source records attributed to G Fantuzzi.

99 records · Page 6Linked to original sources
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[Halogenated volatile organic compounds in bottled mineral water and soft drinks].

74 mineral natural water samples and 56 samples of different commercial drinks have been analysed by head-space chromatography in order to evidence the presence of volatile halogenated organic compounds (VHO). Trihalomethanes (THM) as drinking water chlorination by-products and trichloroethane, carbon tetrachloride, trichloroethylene and tetrachloroethylene as ubiquitarious substances have been investigated. The presence of VHO has been evidenced in 20,3% of mineral natural water samples and in the 58,9% of the commercial soft drinks: this latest group has usually shown higher levels of the investigated compounds. The results of the present study has been compared with a similar study performed in 1991 in the same area: the VHO values observed in the present study appear to be lower than those obtained in the previous study.

Beverages↗
PubMedDate not supplied

[Evaluation of fluoride content in Modena water].

The Authors confirm the importance of fluoroprophylaxis in the prevention of Dental caries. They analyze the main methods of fluoroprophylaxis pointing out the systemic fluoroprophylaxis, effected by means of water fluoruration, as the best one for a valid prevention of dental caries on a large scale. In view of such a kind of fluoroprophylaxis in our country the Authors considered quite interesting to effect a research about the amount of fluoride in the waters of the district of Modena. The whole of results are reported.

Dental Caries↗
PubMedDate not supplied

[Exposure to chloroform in persons frequenting an indoor swimming pool].

Exposure to chloroform (CHCl3) in indoor swimming pool swimmers. CHCl3 presence has been evidenced many times in water and air of indoor pools as a consequence of water chlorination with sodium hypochlorite or other chlorinated disinfectants. In previous studies CHCl3 in environmental air appeared at a high concentration within one meter over the surface of the water and was correlated to the number of swimmers inside the pool. CHCl3 has also been evidenced in blood serum samples of people present at the swimming pool, at different levels depending on: the concentration in the environmental air, the intensity and the length of the sport activity and the number of swimmers in the pool. At the end of the swimming session CHCl3 concentration tends to lower quickly and usually is no longer detectable within half an hour. Other studies have evidenced CHCl3 in breath samples (alveolar air) of a volunteer subject who swam one hour every day in an indoor pool in Modena. The spirometric parameters of the same subject were evaluated in order to estimate his CHCl3 uptake during time spent at the swimming pool, both resting and swimming in different modes. In the present paper the A.A. report data about CHCl3 exposure, intake and uptake bin five agonistic swimmers (three males and two females), members of the same sport association, and regularly attending the same indoor swimming pool in Modena. The five subjects have been examined during four different sessions. Within every session the samples were collected in five different moments according to the following scheme: 1) Hygiene Institute: samples of blood, alveolar air, environmental air. 2) Swimming pool, after 1 hour sitting near the pool edge: samples of alveolar air, environmental air (within 1 m on the water surface). 3) Swimming pool, after 1 hour swimming: samples of blood, alveolar air, environmental air (within 1 m on the water surface). 4) Hygiene Institute, 1 hour after the end of the swimming time: samples of alveolar air, environmental air. 5) Hygiene Institute, 30 min after the previous sampling: samples of alveolar air, environmental air. Spirometric parameters have been evaluated in every subject, after resting and swimming (point 2 and 3). CHCl3 uptake has been calculated using the following formula: U = V(CI--CA)t where: U = uptake (microgram/h) V = pulmonary ventilation (l/min) CI = inspired (environmental) concentration (microgram/m3) CA = alveolar concentration (microgram/m3) t = exposure time (min) CHCl3 levels after swimming always appeared quite high; however low levels were evidenced also before exposure (point 1).(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
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[Blood, teeth and hair: 3 different materials used to evaluate exposure to lead and cadmium in children living in an industrial zone].

There is a general agreement that children are a population at increased risk with respect to lead and cadmium exposure and to adverse health effects resulting from increased exposure. Different biological indicators such as blood hair and teeth have been used to evaluate lead and cadmium exposure in humans. However, up to date, it has not been established which is the best indicator to provide an assessment of internal exposure. The aim of the present study was to examine the levels of lead and cadmium in hair, blood and teeth of children living from birth in an industrialized area near Modena. The relationship between these indicators of exposure and children characteristics such as sex, weight, height, blood pressure and smoking habits of parents was also examined. 142 children (71 males and 71 females) representing 20.8% of those aged 6-7 years living in Sassuolo (Modena) have been included in the study. The geometric means of lead in blood, hair and teeth were 11.2 micrograms/dl, 7.24 micrograms/g and 6.16 micrograms/g, respectively. Hair lead were significantly related to both blood and teeth values (r = 0.226, p = 0.007 and r = 0.186, p = 0.027, respectively). Mean cadmium concentrations were 0.47 mu/l in blood, 0.17 micrograms/g in hair and 47.9 ng/g in teeth and no significant correlation was observed between the three biological matrixes examined. Significant correlations were found between lead and cadmium in both hair (r = 0.427, p = 0.000) and teeth (r = 0.224, p = 0.007). In addition, for lead content in teeth, a significant difference between boys and girls was observed; females showed higher values than males (6.77 micrograms/g vs 5.61 micrograms/g; t = 2.23 p = 0.028). Taking into account the individual characteristics of children, a negative relationship was found between Pb levels in teeth and height (r = -0.217, p = 0.024). Systolic blood pressure values were positively associated to cadmium hair levels in males but not in females (r = 0.281; p = 0.053). From the results of the present study it appears that blood, hair and teeth provide different information to predict lead and cadmium exposure of children. Hair seem to be a useful global indicator of total environmental pollution.

Cadmium↗
PubMedDate not supplied

Endogenous nitric oxide production by human monocytic cells regulates LPS-induced TNF production.

The ability to produce nitric oxide (NO) of human monocytes macrophages is object of debate. While studying the regulation of tumor necrosis factor (TNF) synthesis induced by endotoxin (LPS) in a human cell line of monocyte origin (THP-1) and in human peripheral blood mononuclear cells (PBMC) we found an indirect evidence of such production. We showed that L-N-monomethyl-arginine (L-NMMA), an inhibitor of NO synthase, and hemoglobin, a chelator of NO, are able to significantly reduce TNF synthesis, indicating that NO production is induced by LPS and contributes to the induction of TNF. Since NO is a known cytostatic agent, we also studied the cytostatic effect of LPS, and demonstrated that it is reverted by L-NMMA. Although we were unable to show any nitrites/nitrates accumulation in the culture media, taken together our data give an indirect evidence of a physiologically relevant LPS-induced NO production in human monocytes-macrophages.

Arginine↗
PubMedDate not supplied

Protective effect of chlorpromazine on TNF-mediated hapten-induced irritant reaction.

Picryl chloride-induced irritant reaction (IR) was shown to be mediated by tumor necrosis factor (TNF). Anti-TNF monoclonal antibodies, but not interleukin 1 receptor antagonist (IL-1 Ra), had a protective effect. Chlorpromazine (CPZ), an inhibitor of TNF synthesis, protected against IR and inhibited the IR-associated TNF induction in ear homogenates. Investigation of the role of polymorphonuclear leukocyte (PMN) in neutropenic mice showed that neutropenia did not prevent the development of the IR.

Animals↗