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Biomedical subjects

G Fechner

Publications and source records attributed to G Fechner.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Cessation of livor in defined pressure conditions].

In 28 cases of sudden death, the corpses were tested for the effect of different storage temperatures (5 degrees C, 14 degrees-15 degrees C, 25 degrees C) regarding the reaction of livor mortis to known pressure conditions (force and duration of pressure). The reaction is dependent on the storage temperature but there is no linear relationship. At certain storage temperatures the postmortem lividity reaction is dependent on the amount and duration of the pressure. In addition, at defined storage temperature and pressure conditions, there are large interindividual differences in the estimation of time of death.

Death, Sudden↗
PubMed1984

Identification of mechanical asphyxiation in cases of attempted masking of the homicide.

Five homicides are described that had remained unexplained as to the causes of death after gross pathology. Although general signs of asphyxiation were present, they were lacking injuries specific of strangulation or oro-nasal occlusion. The diagnoses of asphyxiation were established by microscopical investigation of the lung and confirmed by subsequent police inquiries. An oro-nasal occlusion was involved in three cases, a strangulation or an oro-nasal occlusion, in another case. The victims were young and healthy. Toxicological investigations remained negative in four cases; one victim was anaesthetized by bromazepam and ether and had a blood alcohol concentration of 80 mg/100 ml. Lung histology and electron microscopy revealed acute emphysema, the development of a haemorrhagic-dysoric syndrome and a microembolism syndrome. With regard to the haemorrhagic-dysoric syndrome, the development of alveolar-interstitial edema is particularly important. This finding may also be diagnosed by light microscopy in semi-thin sections. It is emphasized that the combined action of several pathomechanisms is responsible for the rapid manifestation of the pulmonary lesions. Especially, the haemorrhagic-dysoric syndrome is brought about by the combined action of inspiratory intrapulmonary vacuum and raised intracapillary pressure. The complex pattern allows to compile the diagnosis of mechanical asphyxia even if there is no corresponding injury.

Adolescent↗
PubMed1983

[Lung histology in experimental drowning].

Experiments were carried out on anesthetized rats which had to aspirate actively watery fluids of different osmolarities (range: freshwater--2.9% NaCl solution) by a tracheotomy tube. The cytologic and histological alterations which are to be found are mainly of osmotic origin. In aspiration of hypotonic solutions macroscopy shows the well-known emphysema aquosum. Corresponding to the structure of the respiratory system, the histological alterations show areolar limitations. The influx of fluids causes a wide range of reactions from the development of an alveolar-interstitial edema in combination with intracellular and intercellular vesiculation, karyolysis with swollen homogenized nuclei of the subendothelial, septal, and epithelial cells to a necrosis of all the cellular elements. A pronounced microangiopathy with edema of the vascular walls, a hydrops of the myocytes containing large vacuoles and perivascular edema with dilated lymphatic channels are likewise to be found. The alveolar macrophages are considerably increased. Sporadic ruptures of the alveolar walls and microhemorrhages occur. In salt water drowning alterations of the shape of both the erythrocytes (thorn-apple form) and the alveolar epithelium in combination with a striking of the pneumocytes and villous transformation prevail. Besides, these are capillary hyperemia and sludge. In a careful specimen analysis a differentiation of the findings between vital reactions and postmortem fluid impact is possible.

Animals↗
PubMed1983

[Ultrastructural pathology of the alveolar apparatus in experimental drowning].

Investigations were carried out on anaesthetized rats which by a tracheotomy tube actively aspirated liquids of different osmolarities covering a range from tap water to 2.9% NaCl solution. In every range of osmolarity, the ultrastructural alterations show areolar limitations and different stages of development. In freshwater the influx of liquid causes a hypoxemic-dysoric alveolose with diffuse of pulvinate oedematous swellings of all compartments of the blood-gas-barrier, cytolysis, karyolysis, membrane desintegration, hydropic alterations of the (cell) organelles, dilatation of the drainage tracts of the alveolar interstitium. Vesicular transformation caused by a dilatation of the pinocytotic system ending in endothelial and epithelial vesiculation. Salt-water drowning leads to a hypoxemic alveolose with a marked compaction of the matrix. The epithelium shows many alterations of the surface, numerous protrusions, constrictions and expose of the basement membrane (villous transformation). Erythrocyte sludge and thorn-apple-shaped erythrocytes are found in the capillaries. Application of electron microscopy in the diagnosis of drowning allows a more reliable classification and, correspondingly, decisive improvements of the reliability of lightmicroscopical findings.

Animals↗
PubMed1976

[Effects of hypertrophy on the behavior of potentials in isolated ventricular strips of the rat].

Potentiation of right-ventricular strips obtained from normal rats (NT-group) and from rats showing hypertrophic hearts as a result of long-time swimming (HT-group) has been investigated. Strength-interval relationships, poststimulation potentiation and the potentiation by paired stimulation has been tested. The behavior of the action potential in both groups showed no significant differences. Standardized strength-interval relationships of HT-group were steeper than those of the NT-group. Maximal potentiation in the HT-group occurred at shorter delay-intervals. Potentiation after long-time pauses was greater in the HT-group. The results are discussed on the basis of model considerations of electro-mechanical coupling.

Action Potentials↗