Biomedical subjects

G Fenichel

Publications and source records attributed to G Fenichel.

5 recordsLinked to original sources

PubMed1997

A beneficial effect of oxandrolone in the treatment of Duchenne muscular dystrophy: a pilot study.

We treated 10 boys with Duchenne muscular dystrophy with oxandrolone, an anabolic steroid, for 3 months. The mean of the changes in the average muscle score was an improvement of 0.315 +/- 0.097. The expected mean change in muscle score after 3 months from natural history data is a loss of 0.1. The difference of 0.415 between the actual and expected values is significant at p < 0.01. This preliminary evidence suggests that oxandrolone treatment may provide a degree of functional benefit for children with Duchenne muscular dystrophy that is similar to that after prednisone administration.

Anabolic Agents↗

PubMed1993

The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency.

The glycolytic enzyme phosphoglycerate mutase (PGAM) is a dimer, and mature human skeletal muscle contains almost exclusively the MM form of the enzyme, PGAM-M. In 1981, we identified a patient with PGAM-M deficiency, and three additional patients have since been described. All presented with exercise intolerance, cramps, and myoglobinuria. We report two new patients with PGAM-M deficiency and describe the molecular lesions in five patients--four African-Americans and one Caucasian. Three patients were homozygous for an identical G-to-A transition converting an encoded Trp to an in-frame stop codon (codon 78). A fourth patient was heterozygous for this mutation and also carried an A-to-C mutation converting Glu to Ala (codon 89). The fifth patient, the only Caucasian, was homozygous for a different point mutation, a C-to-T mutation, converting Arg to Trp (codon 90).

Adolescent↗

PubMed1984

Contrasts in the professional identities of psychiatrists and internists.

Projected manpower shortages in psychiatry have prompted studies identifying factors that influence medical students in career choice. In the present study, the authors compare self-images as individuals with professional images of psychiatrists using subjects from internal medicine as a control group. A total of 353 subjects from two university clinical practices completed questionnaires that utilized the Osgood Semantic Differential to determine attitudes in the areas of evaluation, potency, and activity. The hypothesis that psychiatrists differ significantly in their self-images as individuals and their professional role images was partially confirmed. In the areas of activity and power, significant (p less than .001) differences existed in their attitudes. In the concept of evaluation, the self-images and the professional images were similar. The impact of these discrepancies on students making career choices is discussed.

Career Choice↗

PubMed1977

Neural influence on experimental myotonia.

A transitory myotonic state, lasting for less than 24 hours, was induced in rats within 2 hours of the intraperitoneal injection of 2,4-dichlorophenoxyacetic acid. Neuromuscular blockade, nerve block, nerve section, and cordotomy had no effect on the established myotonic state. However, muscle that had been denervated progressively lost its capacity for a myotonic response to subsequent injections of 2,4-dichlorophenoxyacetic acid. After 10 to 12 days denervation, the injection of 2,4-dichlorophenoxyacetic acid produced a brief increase in the number of fibrillations, but typical myotonic discharges were no longer detectable. Unlike denervation, cordotomy did not impair the capacity of the paralyzed limbs to develop in response to 2,4-dichlorophenoxyacetic acid. While myotonia is the result of a primary defect in the muscle membrane, these experiments indicate the innervation is necessary to maintain the muscle membrane in a state that will support myotonia. We hypothesize that an alteration in ionic conductance secondary to denervation is the critical factor in preventing myotonia.

2,4-Dichlorophenoxyacetic Acid↗

PubMed1967

Migraine.

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Adolescent↗