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Biomedical subjects

G Fini

Publications and source records attributed to G Fini.

24 records · Page 2Linked to original sources

[Role of integrated imaging (computerized tomography and echography) in the surgical reconstruction of the external ear].

Three-dimensional Computed Tomography (3DCT) imaging methods of the skull and ribs by axial and contiguous slices allow the selective rendering of the involved structures. The possibilities given by variable threshold ranges allow 12-bit density structures (Hounsfield Units) to be obtained within threshold limits. Imaging has been optimized by shading solids. Such methods, together with US (duplex-Doppler) techniques, offer new diagnostic possibilities relative to the treatment planning of patients with either congenital malformations or acquired abnormalities of the external ear and in the evaluation of associated abnormalities of craniofacial areas. In the reconstruction of the earlap by autograft of modelled rib cartilage, after preparing an expanded otomastoid skin flap, the above methods allowed accurate preoperative planning with consequently significant reduction of surgical time and better clinical results. Six patients with earlap abnormalities (four with microtia due to complete hemifacial microsomia syndrome, one with anotia and one with post-traumatic loss of the earlap) were studied for reconstruction. High-quality 3DCT images of the rib and auricolar cartilage were obtained in real-scale representation (1:1 ratio) the evaluation of the donor site and of the autograft size. Useful pieces of information on the development and vascularization of an expanded otomastoid flap, after gradual and constant expansion, were given by duplex-Doppler US, which allowed easy monitoring in both surgical planning and follow-up.

Adolescent↗

[PTFE in reconstructive surgery on the face].

The employment of synthetic materials instead of autologous tissues (cartilaginous, adipose tissue, etc.) is already well codified and widely spread: the only restraint to their use is represented by biocompatibility which is not always satisfactory. Prosthesis should be clinically inert and inalterable with time, easy to sterilize, intraoperatively mouldable, and, from the aesthetic point of view, unrecognizable at touch. Since PTFE is widely used in general surgery (vascular prosthesis, aortobifemoral bypass, ect.) we have employed it in plastic surgery obtaining good results in the correction of malar depressions, and in harmonizing the final result of a rhinoplasty or of a labial plasty. All patients showed to well tolerate the material employed without any evident inflammatory reaction and with stable results at long-term follow-up.

Adult↗

Raman spectroscopic investigations on conformational changes induced by some phenol derivatives on phospholipid membranes.

Some phenol derivatives which uncouple oxidative phosphorylation in mitochondria alter the dipalmitoylphosphatidylcholine membrane structure in the same way that elevating the temperature does. Below the transition temperature, they disorder the membrane gel-phase by inducing the pretransition situation at concentrations within significant biological limits. When the temperature is higher than Tm, their effect on the membrane structure is negligible. The comparison of these phenol derivatives having uncoupling activity with a phenol derivative which does not have such activity demonstrates that the latter does not induce a similar physical effect.

2,4-Dinitrophenol↗

Spectroscopic behavior of copper complexes of nonsteroidal anti-inflammatory drugs.

The proposed curative properties of Cu-based nonsteroidal anti-inflammatory drugs (NSAIDs) have led to the development of numerous Cu(II) complexes of NSAIDs with enhanced anti-inflammatory activity. Crystalline complexes, Cu(II)-NSAID (ibuprofen, naproxen, tolmetin, and diclofenac), with a carboxylic function have been studied by means of infrared and Raman spectroscopy. All NSAIDs bind the metal through the carboxylate group. On the basis of the comparison between the wavenumber of the COO(-) group vibrations and Delta nu (nu(asimm)COO(-) - nu(simm)COO(-)) between Na salts and Cu(II) complexes, conclusions on the probable structure of the complexes have been drawn. The spectroscopic data support the formation of dimeric [Cu(2)L(4)(H(2)O)(2)] complexes in which the COO(-) group behaves as a bridging bidentate ligand. The low wavenumber region of the Raman spectrum provided information on Cu-O and Cu-Cu bonds in the complexes. Thermogravimetric results gave further support to the vibrational data.

Anti-Inflammatory Agents, Non-Steroidal↗

[Indications for the use of a skin-stretching device].

In the management of surgical or traumatic skin loss the Authors consider an alternative method which involves the use of a tool called skin stretching device. The latter seems easy to apply, atraumatic and the least troublesome for the isolation and detaching of tissues employed in skin repair.

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