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Biomedical subjects

G Finikiotis

Publications and source records attributed to G Finikiotis.

12 recordsLinked to original sources
PubMed1992

Outpatient hysteroscopy: a comparison of 2 methods of local analgesia.

A prospective, randomized study was undertaken to objectively compare pain tolerance of 2 methods of local analgesia for outpatient hysteroscopy. Patients in group 1 received a paracervical block using 20 ml of 1% lignocaine. Patients in group 2 received a uterosacral block using 2 ml of 2% lignocaine. There was no statistical difference between the 2 groups (p = < 0.65) in efficacy of pain relief. The method used for patients in group 2 reduces time and costs for outpatient hysteroscopy.

Ambulatory Surgical Procedures↗
PubMed1990

The hyperaemic endometrium at hysteroscopy.

Five hundred and thirty seven hysteroscopies were performed on 523 patients. In 37 cases, diffuse hyperaemia was the only abnormality found. Directed biopsy or dilatation and curettage (D&C) was performed on 28 of these, none of which revealed histological abnormalities. The hysteroscopically visualized hyperaemic endometrium was detected in all phases of the menstrual cycle, in the postmenopausal state and in patients on hormonal therapy. In the absence of excessive thickness of the endometrium or other abnormalities, hyperaemia was not found in increased association with organic uterine pathology. The results suggest that hysteroscopy and directed biopsy of hyperaemic areas is adequate and may replace D&C as a first line of investigation.

Endometrium↗
PubMed1990

Chorion villus sampling--transcervical or transabdominal?

Chorion villus sampling was performed transcervically on 84 patients and transabdominally on 126 patients. Two of 4 (5%) spontaneous abortions in the transcervical group were complicated by uterine infection. Five (4%) spontaneous abortions in the transabdominal group were uncomplicated by infection. The results support the contention that the transabdominal method may be safer and that the procedure related fetal loss rate is similar to that following amniocentesis.

Abdomen↗
PubMed1989

Hysteroscopy: an analysis of 523 patients.

An analysis is presented of the indications for, and findings on, hysteroscopy in 523 patients undergoing gynaecological investigation or treatment. Abnormal uterine bleeding or discharge was the indication for investigation in 202 patients. Based on hysteroscopic observation, dilatation and curettage (D & C) was adjudged unnecessary in 114 (56%) and a subsequent D & C on these patients revealed no histological abnormalities. In the remainder, more abnormalities were observed visually on hysteroscopy than were detected by D & C. The results suggest that D & C should be replaced by hysteroscopy and biopsy as a first-line investigation of abnormal uterine bleeding or discharge.

Adult↗
PubMed1989

Abnormal cornual ostia and infertility.

Hysteroscopy performed on 126 infertile patients and on 73 fertile patients revealed a significant association between abnormal uterine cornual ostia and infertility (p less than 0.002). Ostial abnormalities included absence of cupping with uterine cavity distension, diminution of ostial diameter and complete ostial occlusion. High intrauterine pressures from dye perturbation can overcome the occluded ostial state giving a false impression of adequate tubal patency. These findings may explain some cases of apparently unexplained infertility and may bear on the success rates of procedures such as artificial insemination and gamete intrafallopian transfer.

Female↗
PubMed1985

Prenatal diagnosis. A preliminary study of first-trimester chorionic villous biopsy.

Biopsy of the developing placenta before the thirteenth gestational week was performed by transcervical cannula aspiration guided by real-time ultrasound in 21 consecutive patients. Chorionic villi were obtained in 20 patients and chromosomal analysis was possible in 19. One significant complication occurred: perforation of one gestational sac in the only patient in the series with a twin pregnancy. More studies are required in order to provide an adequate assessment of the risk--of fetal loss, culture failure and trophoblastic chromosomal abnormalities not representative of the mature fetus--associated with the technique. In practised hands, the procedure may provide a preferable and safe alternative to amino-centesis and fetoscopy for the prenatal diagnosis of genetic defects.

Biopsy↗
PubMedDate not supplied

Prenatal diagnosis of Zellweger's syndrome by chorionic villus sampling--and a caveat.

At 7.5 weeks gestation, two small chorionic villous biopsies were obtained from a woman at risk for Zellweger's cerebro-hepato-renal syndrome, and were separately established in culture. After 3 weeks, dihydroxyacetone phosphate acyltransferase (DHAP-AT) activity was measured in both cultures. The enzyme was markedly deficient in one cell strain and this was subsequently shown to have a male karyotype. However, the second culture had normal enzyme activity and a female karyotype. The pregnancy was terminated at 11.5 weeks gestation, and follow-up studies on fetal tissues confirmed a male fetus with markedly deficient DHAP-AT activity.

Acyltransferases↗