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Biomedical subjects

G Fiorini

Publications and source records attributed to G Fiorini.

33 records · Page 2Linked to original sources
PubMed1983

Monoclonal antibody-defined peripheral blood T lymphocyte subpopulations in patients with mycosis fungoides.

A panel of monoclonal antibodies has been used to identify peripheral blood lymphocyte subpopulations in 13 patients with mycosis fungoides and in 13 normal subjects. An increase in the T6+ population and a decrease in the T8+ population were noticed in our patients. Their T4/T8 ratio was considerably augmented. In 4 patients reevaluated after treatment, marked changes in the relative proportions of T lymphocyte subsets had occurred. The possible pathogenetic significance of these immunological alterations is discussed.

Adolescent↗
PubMed1983

T-lymphocyte subsets in primary and secondary glomerulonephritis.

T-lymphocyte subsets, using the monoclonal antibodies OKT3 (peripheral T-cells), OKT4 (helper/inducer T-cells) and OKT8 (suppressor/cytotoxic T-cells) were measured in peripheral blood from 110 patients with various forms of primary and secondary glomerulonephritis (GN) (Berger's disease, membranous GN, focal glomerulosclerosis, membranoproliferative GN, lupus nephritis and mixed essential cryoglobulinaemia with GN). We have found a significantly higher OKT4+/OKT8+ ratio in patients with Berger's disease and membranous GN and a rather low OKT4+/OKT8+ ratio in patients with lupus nephritis and mixed essential cryoglobulinaemia, due to a significant decrease in OKT4+ cells. Our results suggest an imbalance in immunoregulatory mechanisms in some forms of GN.

Adolescent↗
PubMed1983

Correlation between helper/suppressor ratio and IgA levels in the peripheral blood from patients with liver diseases.

The correlation between serum immunoglobulin levels and "helper/suppressor" (T4/T8) ratio has been investigated in 45 patients with biopsy proven liver diseases (22 with ALD, 16 with CAH and 7 with VHR). In the ALD and CAH groups the T4/T8 ratio was significantly higher than in normal controls and a strong correlation was noticed with IgA, but not IgG and IgM levels. The same correlation was found in the VHR group as well, even if the mean value for the T4/T8 ratio in these patients was not significantly above that of normal controls. The pathogenetic significance of these findings is discussed.

Adult↗
PubMed1983

Acquisition of deoxyguanosine resistance by TPA-induced T lymphoid lines.

The human leukemic T cell line 8402, which contains terminal deoxynucleotidyl transferase (TdT) and phenotypically resembles precursor thymocytes, when exposed to the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate (TPA) undergoes in vitro T maturation. TdT disappears from virtually all the cells and a fraction of TdT- -cells express specific T surface markers, such as the T3 determinant. Like T lymphocytes from the thymus, 8402 cells are extremely sensitive to the cytotoxic effect of deoxyguanosine (dGuo). As a consequence of TPA treatment, resistance to dGuo is observed in 8402, as well as in two other TdT+ lymphoid T cell lines, Molt-4 and CEM-10. These results suggest the occurrence of changes in deoxynucleoside metabolism in TPA-treated cells related to the in vitro maturation process. Maturation of 8402 cells, once started, progresses in the presence of additional physiologic stimuli provided by conditioned medium from lymphocyte culture, because a portion of cells display the T8+/T4- phenotype characteristic of cytotoxic/suppressor T cells. This in vitro lymphoid system may thus be used to study the relationships of molecular differentiation between precursor thymocytes and cytotoxic/suppressor T cells.

Animals↗
PubMed1982

Immunological monitoring of a patient with Guillain-Barré syndrome successfully treated with plasma exchange.

A patient with Guillain-Barré syndrome was successfully treated by plasma exchange (without any other therapy), and the relationship between changes in his peripheral blood lymphocyte subpopulations and the clinical improvement induced by plasma-pheresis was studied. At the recovery, the most interesting findings were an increase in T suppressor lymphocytes, and in Fc receptor-bearing lymphocytes (above normal values), together with a decrease in B lymphocytes. In this patient, plasma exchange not only removed toxic humoral factors, but also restored a normal balance among peripheral lymphocytes.

Aged↗
PubMedDate not supplied

Significance of circulating C1q-binding activity in chronic liver disease: a study of 133 cases.

Circulating immune complexes (CIC) were measured in 133 biopsy-proven patients with various liver diseases. The correlation between CIC levels and other laboratory findings was investigated in each disease group, in order to assess if the increased C1q-binding activity found in these patients was related to particular features of the disease. CIC levels were not significantly different in HBsAg-positive and HBsAg-negative patients. No correlation was found between CIC levels and serum bilirubin, AST, ALT and C3 levels. A negative correlation with C4 levels and a positive correlation with immunoglobulin levels were found in the majority of the patients, while prothrombin time and albumin levels were negatively correlated to CIC levels only in patients with chronic active hepatitis. Increased CIC levels could represent a response to gut-associated antigens, a passive accumulation due to reduced hepatic function or both.

Alanine Transaminase↗
PubMedDate not supplied

[Renal hemangiopericytoma. Anatomo-pathologic and clinico-therapeutic considerations. A case report].

The Authors report a case of renal hemangiopericytoma, whose interest is related to the extreme rarity (24 cases reported until today), its insidious growth, the late in diagnosis, its uncertain clinical-biological evolution, not always predictable. Considering chemotherapy and radiotherapy ineffectiveness, an adequate treatment for such a neoplasm requires the surgical therapy, which must be followed by a careful follow-up.

Adult↗
PubMedDate not supplied

Radiological assessment of clinical staging of lung cancer.

Technical details of volumetric spiral CT and high resolution CT are presented. The role of CT scan in lung cancer is discussed: confirmation of a suspected lesion, identification of an unknown one, clinical staging, planning bioptic procedures and follow-up. In clinical staging, CT scan measures tumor diameter and relationship with surrounding structures (T factor) as well as investigates about nodal status (N factor) at the hilum or in the mediastinum but the limitation is due to the difficulty of distinguish between nodal inflammatory enlargement and metastatic involvement. Moreover, CT can be extended to the upper abdomen aimed of assessing adrenals, kidneys and liver (M factor).

Biopsy↗