PubMed Health⌕ Search

Biomedical subjects

G Fishman

Publications and source records attributed to G Fishman.

At least 37 records · Page 2Linked to original sources
PubMed1990

Suicide in the Israeli army.

The present study was an attempt to analyze the problem of suicide in the Israel Defense Forces (IDF). Suicide is increasing among populations aged 18-21, which in Israel is the age when most young people are called up for a 3-year period of compulsory military service. The service may have a catalytic effect on suicide. but on the other hand may serve as a control mechanism reducing suicide. The study used data for the period 1974-1985, and examined suicide in combat and noncombat units by duration of service and by preservice psychiatric, medical, and motivational data. The suicide groups were also compared with a matched sample of nonsuicide groups along the relevant variables. The findings seem to be consistent with some established theoretical perspectives of situational stress, social support, and status incompatibility, and seem to bear practical implications for the reduction of suicide.

Achievement↗
PubMed1985

Vitreous fluorophotometry studies in retinitis pigmentosa.

Six patients with various genetic types of retinitis pigmentosa and ten carriers of the X-linked recessive type were studied by vitreous fluorophotometry. Kinetic vitreous fluorophotometry showed an alteration of the blood-retinal barrier (BRB) in patients with retinitis pigmentosa, even in those who had minimal fundoscopic abnormalities and only minor changes on the electroretinogram. Furthermore, an alteration of the BRB could be detected in the carriers of the X-linked recessive form of retinitis pigmentosa. In general, higher concentration of fluorescein in the vitreous correlated topographically with the extent of photoreceptor and retinal pigment epithelial disease, as well as with the presence of leakage from retinal capillaries.

Adolescent↗
PubMed1984

Evaluation of intravitreal 5-fluorouracil, vincristine, VP 16, doxorubicin, and thiotepa in primate eyes.

A single intravitreal dose of 750 micrograms 5 fluorouracil (5 FU) or 5 micrograms doxorubicin were nontoxic to primate eyes. A concentration of 250 micrograms/ml of 5 FU in the vitrectomy infusion fluid in combination with 8 micrograms/ml of thiotepa, with 40 micrograms/ml of VP16 (etoposide), or with either .04 or .02 microgram/ml of vincristine was also well tolerated by the primate eye. 5 micrograms/ml of doxorubicin in the vitrectomy infusion fluid did not cause apparent toxicity to the retina. Toxic effects were noted in eyes receiving 250 micrograms of 5 FU in combination with either .15 or .1 microgram/ml of vincristine.

Animals↗
PubMed1980

Ongoing outcome research on short-term dynamic psychotherapy.

In this paper short-term dynamic psychotherapy (STAPP) is described briefly in terms of its selection criteria and technique, and the preliminary findings of an ongoing outcome study are presented. Of 22 experimental patients who were treated with STAPP, 14 were rated as 'recovered' by two evaluators, 4 were 'much better', 3 'little better' and 1 was 'unchanged'. Of 8 controls who waited a period of 2--5 months, 5 were 'unchanged' and 3 'a little better' at the end of their waiting period. When they were treated subsequently, 4 had 'recovered', 2 were 'much better' and 2 withdrew having moved from the Boston area. The complexities inherent in psychotherapy evaluation are described, and the 3 patients who improved 'a little' and the 1 who was 'unchanged' are discussed briefly.

Anxiety↗
PubMed1979

Visual loss and foveal lesions in Usher's syndrome.

Forty-eight patients with Usher's syndrome were assess for the degree of visual loss, extent of lens opacities, and presence of foveal lesions. Twenty-one patients (44%) showed either atrophic or cystic-appearing bilateral foveal changes. Despite having foveal lesions and variable degrees of lens opacities most patients maintained central visual acuity of 20/60 or better until their middle 30s.

Adolescent↗
PubMed1977

Toxicity of selected antibiotics in vitreous replacement fluid.

Experiments with rabbits demonstrated no toxic effects on the retina after vitrectomy when the infusion fluid contained either 20 microgram/ml chloramphenicol saline, 10 microgram/ml amikacin saline, 10 microgram/ml tobramycin saline, or 10 microgram/ml clindamycin saline. We found abnormal electroretinograms and abnormal histologic findings in eyes receiving vitreous replacement with these same drugs in higher concentrations.

Amikacin↗
PubMed1975

The toxicity of intravitreal whole blood and hemoglobin.

To determine the toxic effect of whole blood and hemoglobin on the retina, volumes of autogenous blood varying between 0.3 and 1.5 ml and various hemoglobin concentrations were injected intravitreally into speciosa monkeys. Electroretinograms were performed at the outset of the experiment and immediately before sacrifice. After six weeks the animals were killed and the eyes were processed for histologic and electron microscopic examination. Three intravitreal injections of 0.3 ml of autogenous blood administered at one-month intervals or one injection of 22.4 mg of hemoglobin did not produce a toxic effect on the retina demonstrable by light or electron microscopic examination or electroretinography. Intravitreal injection of more than 0.6 ml of whole blood or 40 mg of hemoglobin produced definite toxic effects histologically and electroretinographically. The damage found histologically correlated well with the degree of hemosiderin deposition. Explosive lesions produced by xenon are photocoagulation to induce moderate vitreous hemorrhage failed to produce toxic doses of blood within the eye. In humans undergoing vitrectomy to remove vitreous hemorrhage, the amount of whole blood recovered from vitrectomy fluid was considered nontoxic, except when the patient had massive vitreous hemorrhage or intraoperative bleeding.

Animals↗
PubMed1975

Intravitreal injection of cephaloridine in the treatment of endophthalmitis.

Ocular toxic effects of intravitreal injection of cephaloridine in rabbits was evaluated, and none were produced in doses of 0.25 mg or less. Clinically, intravitreal injection of cephaloridine in doses of 5 mg or more produced small punctate hemorrhages in the vascularized portions of the rabbit retina within two days. With doses of 2.5 mg or less, no clinical changes were seen during the two weeks of observation. Histologically, one day following intravitreal injection of 0.5 to 10 mg of cephaloridine there was clumping of the outer segments of the photoreceptors and destruction of the retinal pigment epithelium. Ten milligrams of cephaloridine intravitreally injected caused definite electroretinogram (ERG) changes ten minutes after injection. After 24 hours, the ERG was extinguished. An experimentally induced Escherichia coli endophthalmitis was successfully treated after six hours by intravitreal injection of cephaloridine.

Animals↗