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Biomedical subjects

G Franzen

Publications and source records attributed to G Franzen.

12 recordsLinked to original sources
PubMed1997

Prognostic significance of nucleolar organizer regions in adenoid cystic carcinomas of the head and neck.

OBJECTIVE: To determine the prognostic use of nucleolar organizing region (AgNOR) counts and clinical and histopathological features in adenoid cystic carcinoma. DESIGN: Argyrophilic staining was applied to ordinary formalin-fixed, paraffin-embedded specimens and evaluated to obtain the mean number of AgNORs and the percentage of nuclei with more than 1 (pAgNOR > 1), more than 2, more than 3, and more than 4 AgNORs. RESULTS: Using the log rank test, the mean AgNOR count showed no correlation with the disease-free period. All pAgNOR parameters exceeding the respective overall mean had poorer prognosis when compared with those below the mean (P = .02). The pAgNOR > 1 appeared as the best discriminator, singling out all treatment failures (P < or = .001). This parameter also showed a high degree of intraobserver and interobserver reproducibility. Stage of the disease, violated resection margins, and presence of the histopathological solid subtype were markers of an unfavorable prognosis. Multivariate analysis by the Cox model showed that pAgNOR > 1 (P < or = .001) and tumor stage (P = .03) were the only statistically significant parameters. CONCLUSIONS: Estimation of pAgNOR > 1 is easy, quick, and highly reproducible. It may become a useful prognostic parameter in adenoid cystic carcinoma, but larger studies should be performed to confirm the reliability of this method.

Carcinoma, Adenoid Cystic↗
PubMed1986

A comparison of static cytofluorometry and flow cytometry for the estimation of ploidy and DNA replication in human breast cancer.

332 primary invasive breast carcinomas were analysed by static cytofluorometry and flow cytometry. The ploidy distributions were similar, and 54% of the tumors were judged DNA aneuploid by both methods. The coefficient of variation of the G0-G1 peaks ranged from 2.0 to 8% with both techniques, but the mean was somewhat lower with flow cytometry--4.1%, compared to 4.9% for the static measurements. The proportion of S-phase cells was possible to estimate from 80% of the flow histograms and 70% of the static histograms. S-phase was not estimated from the static histograms if less than 150 tumor cells were measured. With 160 tumors S-phase was measured by both methods. The range was 0 to 27% with the static measurements and 0.7 to 25% with flow cytometry. Corresponding mean values were 7.6% and 8.2%, which are similar to thymidine labeling index results with breast cancers reported in some studies. A close correlation was obtained (r = 0.927) comparing S-phase fractions estimated from aneuploid tumors with flow cytometry and static cytofluorometry if more than 200 cells were measured with the latter. The proportion of S-phase cells was significantly lower for the diploid tumors. We conclude that both techniques can be useful for the estimation of DNA ploidy and replication in human breast cancer.

Aneuploidy↗
PubMed1985

Comparison between continuous and intermittent administration of Estracyt in the treatment of carcinoma of the prostate.

Ninety-five patients with prostatic carcinoma, stages A-D and of all histological grades were randomized between a continuous and an intermittent treatment regimen of Estracyt (estramustine phosphate). 77 patients were evaluated (46 with continuous and 31 with intermittent therapy). Remissions were seen in 13 (28%) and (13%), respectively. Stable disease was recorded in 30 (65%) and 24 (77%), respectively. Progression experienced 3 (6%) and 3 (10%) respectively. 19% were unable to continue therapy due to intolerable gastrointestinal side effects (7 patients receiving continuous and 8 patients receiving intermittent therapy).

Aged↗
PubMed1983

Treadmill for equine locomotion analysis.

A treadmill for equine locomotion analysis is described and its potential considered for locomotive research and clinical investigation. The treadmill comprised an endless belt driven by a hydraulic motor at various speeds up to 14 m/sec and the direction of belt movement was reversible. The carrying side of the belt ran over a steel-concrete table which acted as a flat support. The belt itself consisted of a steel base on to which was glued a rubber belt and the surface was covered with a layer of coir matting which permitted some forward sliding of the landing hooves simulating the conditions on an ordinary track. The treadway could be inclined up to 10 degree in the longitudinal and 7.5 degrees in the transverse direction. To minimise the risk of injuries a special emergency stop system was installed. Horses adapted well to exercising on the treadmill, even without any previous experience. A good correlation was found between the gait repetitiveness on the racetrack and that displayed on the treadmill. One horse recorded both on the racetrack and on the treadmill showed significantly shorter strides on the treadmill but this did not invalidate the treadmill as a useful research tool in the study of equine locomotion.

Animals↗
PubMed1983

[Circulatory and adverse effects of nonionic contrast media in arteriography. Results of a double-blind study].

The effect to the local toleration of different concentrations of new non-ionic contrast media (Iopamidol 300 and 370) has been examined by means of a randomized intraindividual double-blind study and by the use of uniform parameters of application. In all cases the pain and heat effect were tolerable for the non-anaesthesized patients. The application of the higher concentration of the contrast media did not strengthen or intensify these side effects, which were formerly connected with the arteriography of the extremities. In cases, where the circulation is heavily disturbed, the opacification of the peripheral branches of the leg arteries can be improved by the use of the higher concentration. The hemodynamic effect was low and disappeared after a few minutes.

Adult↗
PubMed1979

[Angiographic diagnosis of haemoptysis with particular reference to angiomas of the bronchial arteries (author's transl)].

It is hardly ever assumed that pulmonary bleeding can be due to the presence of angioma racemosum arteriovenosum. This is not only because it is relatively rare, but also because it cannot be visualised in conventional x-ray films of the lung. It is also not accessible to more detailed and invasive lung diagnosis. Definite confirmation is only possible via selective bronchial arteriography, which is too rarely applied during diagnostic differentiation. The authors observed angioma racemosum arteriovenosum in seven out of 47 patients in whom angiography had been performed after single or repeated haemoptysis; in six of these patients, the angioma was removed by surgery. Bronchial arteriography not only enables visualisation of the characteristic vascular patterns, but also to differentiate this disease against other pulmonary disorders which may also be responsible for the occurrence of haemoptysis. Furthermore, the angiogram enables exact determination of the extension and localisation of the angioma, this being an important prerequisite of successful thoracosurgery.

Angiography↗
PubMed1976

The correlation between permanent septal deformities and nasal trauma during birth.

Both the outer and inner nose as well as the position of the parietal bones of 972 patients at an age of 3 to 82, were examined giving evidence of the configuration of the infant's head at birth and thereby of the "severity" of the birth. In comparison with the sectio-patients the configuration of the infant's head in the birth canal reveals statistically recorded deformations of the outer and inner nose with an obstruction of the nasal breathing in 20% of the patients examined. The degree of the configuration has a definite influence on the degree of the nose deformation. The adjustment of the rotary direction of the infant's head in the 1st and 2nd vertex presentation determines the direction of the nose deformation. The demand of many authors for an immediate rhinological examination and corrections in the newborn child, for instance on the septum, to be performed still in the obstetrical department, must due to our own examinations be advocated.

Adolescent↗