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Biomedical subjects

G Frecus

Publications and source records attributed to G Frecus.

5 recordsLinked to original sources

[The effect of various organochlorine pesticides on the immunologic reactivity of the white rat].

Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.

Adrenal Glands↗

[Changes in various physiological parameters in chickens after entomoxan administration].

Eight weeks of Entomoxan administration to chickens (15 mg/kg live weight) were followed by significant change of certain physiological parameters relating to the blood, liver, suprarenal bodies, and sexual glands. Such variation was taken to indicate the presence of stress suffered by the animals' impairment of carbohydrate and fat metabolism, and defects of hormonal regulation.

Adrenal Glands↗

Effects of 6-hydroxydopamine on the carbohydrate metabolism of skeletal and heart muscles in rest and during exercise.

A mild 10 min exercise, induced by "in vivo" electrical stimulation of the rat gastrocnemius, causes decreases of the muscle glycogen content (G) and phosphorylase alpha activity (PA), and an increase of its overall glycolytic capacity (OGC); in the myocardium, PA decrease of liver glycogen were brought about by peripheral administration of 6-OHDA; these were probably also related to tissue hypoxia. Modifications elicited by exercise in 6-OHDA treated rats (increase of PA, but no modification of G and OGC in GM; decrease of G in the liver; decrease of OGC in M) suggest some impairments of the ability to adapt the tissue metabolism to increased energetic needs.

Animals↗