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Biomedical subjects

G Fresco

Publications and source records attributed to G Fresco.

11 recordsLinked to original sources
PubMed1992

Full-blown hypothyroidism associated with vitiligo and acropachy. Report of one case.

During the first two years after the onset of hypothyroidism, a patient with spontaneous primary myxedema developed thyroid acropachy. Fifteen years before the diagnosis of thyroid disease, he had patchy vitiligo of the face. There were high serum levels of antibodies against thyroglobulin (anti-Tg) and microsomal antigen (anti-M) were present, while the serum levels of antibodies against the second antigen of the colloid and the cell-surface antigen fell within the normal range. Moreover, antibodies to gastric parietal cells, adrenocortical cells or pancreatic islets in the serum were not present. Concerning the immuno-genetic pattern of our patient, his HLA system did not appear to confirm the well documented prevalence in whites with autoimmune disorders of an antigen specificity positive for the locus DR3.

Antibodies↗
PubMed1990

Multicompartmental analysis of triiodothyronine (T3) distribution and metabolism in clinically euthyroid obese individuals.

Triiodothyronine (T3) kinetic studies were performed on ten clinically non-fasting euthyroid obese individuals and on eight normal subjects. Kinetic analysis was carried out according to a three-pool model whose basic approach involved the acquisition of data from both vascular and extravascular sources. The former were represented by the plasma disappearance curves of iv injected radiolabeled T3. The latter included fecal and urinary losses and liver, kidney and thigh uptake. A detailed comparison of the T3 kinetics of obese and normal individuals did not uncover many differences between these two groups in the way the hormone is distributed, metabolized and excreted. The mean value for the plasma equivalent distribution volume of T3(VD3) in obese individuals (27.05 L) was not significantly different from that in controls (24.60 L) nor were significant differences observed between the mean value for the plasma appearance rate of the hormone (PAR3) in obese subjects (29.80 micrograms/day) and that in controls (30.05 micrograms/day). The mean value for the size of the slow pool (Qc), including fatty tissue as well as skeletal muscle, was unchanged in obese individuals when compared with controls, although in the obese subjects the mean value for the mass of fatty tissue was about 5 times greater. In addition, in obese individuals, the mean value for the fractional rate transfer from plasma to the slow pool (Kca), which was 9.06 day-1, did not significantly differ from that in controls (9.22 day-1).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

[Experimental study of the relationships between activation of erythropoiesis and hematotoxicity of some antitumoral agents (author's transl)].

The changes in the blood toxicity of some antitumoral chemotherapeutic agents in the presence of erythropoiesis activation by bleeding are evaluated. The general toxicity seems to be unaffected but the damage to erythropoiesis proved, in absolute terms, to be more severe in the bled animals. The recovery of hematopoiesis was slower after some drug than others. These results are discussed in the light of present knowledge of hematopoietic kinetics and of the relationships between antiblastic drugs and staminal hematopoietic compartments.

Animals↗
PubMedDate not supplied

Adrenal gland photoscanning by means of 131I-iodinated cholesterol.

Photoscanning by means of 131I-19-iodinated cholesterol was performed on 10 patients with various diseases of the adrenal glands. The authors confirmed that the method was suitable for study of the morphology and function of the adrenal glands in disease, especially when combined with stimulation by ACTH or suppression by dexamethasone. The radiation dose absorbed by the thyroid and by the gonads can be controlled during the examination by blocking the iodine trapping and suppression of the gonado-stimulating action, respectively.

Adrenal Gland Diseases↗