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Biomedical subjects

G Frithz

Publications and source records attributed to G Frithz.

At least 55 records · Page 3Linked to original sources
PubMed1981

Comparison of captopril (SQ 14225) with hydrochlorothiazide in the treatment of essential hypertension.

Captopril, a newly developed, orally active inhibitor of the angiotensin-converting enzyme, and hydrochlorothiazide were given alone or in combination to 39 patients with mild or moderate essential hypertension. After a placebo period the patients were randomly allocated in the proportion 3:2 to treatment with captopril (n = 23) or hydrochlorothiazide (n = 16) for dose titration over 4 weeks. The alternative test drug was added thereafter during an 8-week maintenance period if the supine diastolic blood pressure was more than 90 mmHg. The average supine BP reduction in the captopril group was 29/21 mmHg and in the hydrochlorothiazide group 18/15 mmHg. Only one patient who started on captopril had to have hydrochlorothiazide added. Four of those who started on hydrochlorothiazide had to have captopril added. The antihypertensive effects of captopril and hydrochlorothiazide appear to be additive. Among the side effects due to captopril, there were two patients with taste disturbances and another two with rashes.

Adult↗
PubMed1979

Increased red cell content of Zn2+ in essential hypertension.

The zinc content in plasma as well as in erythrocytes was studied in 61 patients with untreated essential hypertension. They displayed an intraerythrocytic mean value of Zn2+ of 128.2 micromoles/l intracellular water, which is significantly higher than the corresponding mean of 101.5 micromoles/l from 42 normal persons. In plasma, on the other hand, the mean zinc value of the hypertensive persons was 15.2 micromoles/l plasma, i.e. well within the normal range of plasma Zn2+. Possible mechanisms underlying the elevated red cell zinc level in hypertension are discussed.

Adult↗
PubMed1979

Adenylate kinase activity in cerebrospinal fluid of schizophrenic and certain other psychiatric symptomatologies.

Adenylate kinase activity in the cerebrospinal fluid (CSF) was investigated in 29 patients with psychiatric symptomatologies. Such activity was demonstrated in 18 of the 19 individuals with schizophrenic or other psychotic or borderline psychotic symptomatology. No activity was seen in the remaining 10 patients with non-psychotic nervous and/or functional somatic complaints, nor in the 20 persons whose CSF was examined in connection with spinal anaesthesia, nor in four who were treated with neuroleptic drugs on nonpsychiatric indications. The findings are compatible with the assumption that in persons with psychotic or borderline psychotic symptomatology a lowered membrane electrochemical potential may be associated with some of the symptoms exhibited.

Adenylate Kinase↗
PubMed1979

Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.

Adenylate kinase activity and glutathione concentration were measured in cerebrospinal fluid (CSF) of 64 consecutive patients admitted for various neurological disorders. These two analyses were performed in addition to conventional examination of the CSF. Neurological symptoms most probably connected in some cases with no and in others with only subtle changes in the central nervous system were linked to no or only moderate activities of adenylate kinase together with no glutathione. 1 patient with meningioma had no adenylate kinase activity at all while 3 patients with malignant brain tumours showed clear activities similar to 3 patients with well established diagnoses of multiple sclerosis. On the contrary, glutathione was absent in CSF of the patients with brain tumours and multiple sclerosis. Various cerebrovascular diseases involving larger areas of the brain tissue resulted in clear adenylate kinase activities in CSF either alone as in 11 of the patients with cerebral infarction or in combination with the appearance of also glutathione as in the remaining 7 patients with cerebral infarction as well as in the 14 patients studied with hemorrhages of the brain.

Adenylate Kinase↗
PubMed1978

Dose-ranging study of the new beta-adrenergic antagonist nadolol in the treatment of essential hypertension.

A preliminary, single-blind, dose-ranging study was carried out in 30 patients with essential hypertension to assess the efficacy of nadolol, a new beta-adrenoceptor blocking agent without intrinsic sympathomimetic action and with an extremely long plasma half-life. After a 2-week period on placebo, patients were treated for 14 weeks with daily doses of 40 mg nadolol (20 mg twice daily). Dosage was increased every second week up to a maximum of 560 mg daily or until the patient was stabilized at an effective normotensive dose level. The results showed that at the end of the trial period there was a significant reduction in both systolic and diastolic blood pressure (approximately 34/21 mmHg) at an average daily dose of 110 mg nadolol. Apart from a tendency to bradycardia, explained by the drug's lack of sympathomimetic action, no other side-effects attributable to treatment were reported and no patient complained of sleep disturbance.

Adrenergic beta-Antagonists↗
PubMed1978

Human red cell content of cyclic nucleotides and cations upon beta-adrenergic blockade.

The content of cyclic nucleotides (cAMP, cGMP) and Mg2+, Zn2+,Na+ and K+ was determined in human erythrocytes and after beta-adrenergic blockade in healthy individuals. The figures for cAMP and cGMP were 4.20 and 3.36 nmoles/ l intracellular volume, respectively. Only slight effects on the cyclic nucleotide content as well as on cation content were seen upon beta-blockade in the erythrocytes. It is concluded that the single determination of red cell cAMP is not a sufficient indicator of beta-adrenergic blockade. The determination of cAMP in combination with cGMP, Zn2+ and Na+ might reflect a beta-adrenergic blockade.

Adolescent↗
PubMed1977

Malignant brain tumours associated with adenylate kinase in cerebrospinal fluid.

Adenylate-kinase activity was measured in cerebrospinal fluid (C.S.F.) from 35 healthy control subjects and 11 patients with brain tumours, of which 9 were malignant and 2 benign. No adenylate kinase could be detected in C.S.F. from the controls or from the patients with benign brain tumours. The enzyme was consistently found in C.S.F. from patients with malignant brain tumours.

Adenylate Kinase↗
PubMed1977

Once a day treatment of hypertension.

Two studies are presented on the possibility of treating hypertension with pindolol once daily. In the first one, patients already treated with multiple doses of pindolol, propranolol or alprenolol were shifted to single dose regime with pindolol, given in the morning. In most cases an adequate blood pressure control could be maintained on a dose of up to 20 mg pindolol. In the other study, previously untreated patients with mild to moderate hypertension were treated from the beginning with a single dose of pindolol. An adequate pressure control was also obtained in most of these patients with a dose not surpassing 20 mg pindolol once daily. In non-responders, the addition of a once daily dose of a diuretic resulted in an adequate pressure control. In both studies side-effects were few. The absence of sleep disturbances and beta-blocker induced bradycardia was particularly noteworthy.

Adult↗
PubMed1976

Pindolol once daily in the treatment of hypertension.

The beta-adrenergic blocking drug pindolol has been used in the treatment of hypertension, using one single dose per day, given in the morning. 16 patients with mild to moderate hypertension were treated with doses which were increased if necessary up to 20 mg, and 14 patients achieved an adequate level of blood-pressure control. The trial was carried out as a single-blind cross-over study. The study shows that pindolol, a non-selective beta-blocker of high potency, may be given once daily as a hypotensive, offering advantages both for patients and physicians. Side-effects were infrequent.

Adult↗
PubMed1976

Serum adenylate kinase activity in the early phase of acute myocardial infarction.

Elevated adenylate kinase activities in serum and urine have been studied among patients suffering from myocardial infarction. 71% of the patients had clearly increased activities in serum already on admission to the hospital, i.e. about 12 hours after onset of symptoms and patients was 45%. A maximum peak value of the activity in serum was seen at 6 hours after admission to the hospital, i.e. about 12 hrs after onset of symptoms and the elevated enzyme activity value persisted for at least 12 hours after admission. The patients with the elevated adenylate kinase activity in serum were arbitrarily divided into three groups as regards activity. It was shown that the difference in activity of ASAT as well as LD of the high and low activity group was significant (p less than 0.01). No such difference was established between these groups for ALAT, usually not being considered as a reliable test enzyme for myocardial infarction.

Acute Disease↗
PubMed1976

Studies on cerebrovascular strokes. II. Clinical findings and short-term prognosis in a stroke material.

This paper reports the second part of an investigation of first-time cerebrovascular strokes in people under 70 years of age. The clinical data of 344 patients, together with the short-term outcome of the disease, are presented. The immediate (one month) overall mortality was 38%. The corresponding percentage for cerebral haemorrhage was 86, for cerebral infarction 20 and for cerebral embolism 28. Of the surviving patients, 111 had to be transferred to some form of institution at discharge after the acute phase; 103 were able to return to their homes. The influence of various factors upon the immediate prognosis is discussed. Of the clinical findings, the level of consciousness and a calculated score based on the neurological symptoms on admission, proved to have the highest predictive value. Using this score it was possible to predict the outcome in about 85%. Single factors very highly associated with a poor prognosis were the co-existence of cardiac disease and renal insufficiency. There was a notably high prevalence of hypercalcaemia.

Age Factors↗
PubMed1975

The effect of glycerol infusion in acute cerebral infarction.

Intravenous administration of glycerol has been used in an effort to improve the prognosis for patients with acute cerebral infarction. Fifty patients were treated actively and 56 served as a control group. The neurological status before, during and after treatment for six days was assessed by a score system. The patients were grouped according to the initial score. Those with the highest and lowest scores did not improve from glycerol infusion. However, the treated patients with intermediate scores, where the prognosis is known to be dubious, showed a significant improvement compared to the controls. The mortality was not influenced. No undesirable side-effects from glycerol were registered.

Acute Disease↗
PubMed1975

Studies on cerebrovascular stroke. I. Epidemiology of first-time strokes in persons under 70 years of age.

The present investigation was carried out to study the incidence of new cerebrovascular strokes (cerebral haemorrhage, cerebral infarction and cerebral embolism) in people under the age of 70. SUCH INFORMATION HAS HITHERTO BEEN LACKING. The material comprises all cases from Uppsala county occurring between 1967 and 1971. The incidence was found to be 36/100,000 inhabitants. Of the total number of strokes, 25% were recurrences. During the period of study the incidence showed a moderate but significant decrease. It is assumed that this decrease is due to an extended and improved treatment of hypertension. It was observed that there were 6 females below 40 years of age. All had been on oral contraceptives at the time of the stroke. There was a high incidence of diabetes and symptoms of cardiovascular impairment (hypertension, transient ischaemic attack (TIA), cardiosclerotic disease) in the series. A high incidence of myocardial infarction was found among the parents of the cases of cerebral haemorrhage. A high incidence of strokes was found among the parents of those having cerebral infarctions.

Adult↗