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Biomedical subjects

G Furman

Publications and source records attributed to G Furman.

11 recordsLinked to original sources
PubMed2005

Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia.

The carcinogenic potential of nelfinavir mesylate (nelfinavir) was evaluated in a 2-year oral (gavage) study on Sprague-Dawley rats at dose levels of 0 (control), 0 (vehicle control), 100, 300 and 1000 mg/kg per day. At the end of the treatment, increased incidences of thyroid follicular cell hyperplasia and neoplasms were observed at 300 (males) and 1000 mg/kg per day (both sexes). There were no other treatment-related effects and no tumors at other sites. Results from previous studies indicated a number of effects in the liver and thyroid, as well as metabolic profiles that suggested nelfinavir might cause thyroid hyperplasia/neoplasia secondary to hormone imbalance by altering thyroid hormone disposition. To investigate this hypothesis, the effects of nelfinavir on gene expression in rat hepatocytes and liver slices (in vitro), thyroxine plasma clearance, and thyroid gland function were evaluated. Compared to controls, gene expression analyses demonstrated an increased expression of glucuronyltransferase (UDPGT) and CYP450 3A1 in nelfinavir-treated rat hepatocytes and liver slices. In rats treated with nelfinavir (1000 mg/kg per day) for 4 weeks, liver weights and centrilobular hepatocellular hypertrophy were increased and minimal to mild diffuse thyroid follicular cell hypertrophy and follicular cell hyperplasia were evident in the thyroid gland. Thyroid-stimulating hormone (TSH) levels were significantly increased (three-fold), while tri-iodothyronine (T3)/tetra-iodothyronine (T4) and reverse T3(rT3) levels were unchanged, indicating that a compensated state to maintain homeostasis of T3/T4 had been achieved. Plasma 125I-thyroxine clearance was increased and the plasma thyroxine AUC0-48 was decreased (24%) compared to control. In conclusion, these data indicate that thyroid neoplasms observed in the nelfinavir-treated rats were secondary to thyroid hormone imbalance. Increased thyroxine clearance contributes to the effects of nelfinavir on thyroid gland function and is probably a result of UDPGT induction that leads to elevated TSH levels in the rat and eventual thyroid neoplasia. These results are consistent with a well-recognized rat-specific mechanism for thyroid neoplasms.

Adenocarcinoma, Follicular↗
PubMed2001

Interdisciplinary health professional education: a historical review.

A historical review was conducted to examine the advances made, nationally and internationally, in interdisciplinary health professional education since the mid-1960s. One hundred and nineteen articles were reviewed and divided by decade into the following subheadings: models, courses, communication/group process issues, and international perspectives. Twenty-seven articles, categorized as models, defined the conceptual field, described curriculum and program development, or provided a framework for evaluation. Thirty-two articles dealt with interdisciplinary courses, focusing on objectives, content areas, or innovative methods. Nine articles contributed content on interdisciplinary communication and group process issues, from which guidelines were abstracted. Fifty-one articles contributed an international perspective, leading to the recognition that interdisciplinary health professional education, practice, and research is a global movement.

Education, Professional↗
PubMed2000

Facilitating factors for, barriers to, and outcomes of interdisciplinary education projects in the health sciences.

Appropriate collaboration and communication among health professionals is viewed as increasingly important in meeting the challenges of today's health care system. Student socialization to interdisciplinary practice is thought to be facilitated through interdisciplinary academic and clinical learning experiences during the educational program. The purpose of this article is to identify factors commonly cited as facilitating and inhibiting interdisciplinary education, to provide insight for the development of successful interdisciplinary education projects.

Allied Health Occupations↗
PubMed1993

Effects of student gender and standardized-patient gender in a single case using a male and a female standardized patient.

BACKGROUND: In previous studies assessing the effects of student gender, standardized-patient (SP) gender, and their interaction on multiple-station examinations of clinical competence, SP gender was confounded with cases, that is, male SPs were used for some cases and female SPs for others. The authors conducted two studies to investigate the effects of gender on a single case by using a male SP and a female SP for the same case. METHOD: Both studies involved one SP case in a comprehensive clinical evaluation used to assess fourth-year students at the end of a required ambulatory care clerkship at Saint Louis University School of Medicine in 1990-91 and 1991-92. In Study 1, 45 students in four rotations saw the same male SP; 42 students in three other rotations saw the same female SP. In Study 2, 69 students in six rotations were randomly assigned either the male SP (28) or the female SP (41) within the same rotation. For each study, to determine the interaction of student gender and SP gender as well as their main effects, analyses of variance were performed on the students' history-taking and physical examination scores and communication skills ratings. RESULTS: Neither study showed a significant interaction of student gender and SP gender on history taking, physical examinations, or communication skills. CONCLUSION: The findings of both studies suggest that the interaction between student gender and SP gender, unconfounded by case content, had no effect on the students' scores and ratings.

Abdominal Pain↗
PubMed1993

A human heart circulation teaching model using fiber-optic markers.

In teaching anatomy, models are invaluable for reviewing certain concepts, especially those requiring three-dimensionality. Marking points of reference most commonly with numbers, arrows, colored dots, or colored pins is essential for the successful use of these models. However, these marking approaches do not necessarily lend themselves to a "hands on" usefulness for students. Therefore, we have designed a model with fiber-optic reference points. Because of the fragility of models prepared from specimens, we used an acrylic case mounted on a wooden base to protect the human heart circulation model. With the aid of a simple penlight held to the wooden base, the fiber-optic strands illuminate for easy identification of key anatomical points. We use this model in conjunction with a printed self-instructional module.

Anatomy↗
PubMed1980

Does sex make a difference? Gender, age, and stimulus realism in perception and evaluation of aggression.

Judged aggressiveness and its justifiability were examined with caricature cartoons and films of people doing comparable things. Effects of viewer gender, interactant gender, and facial expression were examined. Facial expression strongly affected both types of judgment, viewer gender had no influence, and interactant gender contributed slightly. Real-cartoon differences were significant, but accounted for little variance. Major response patterns were similar for films of people and cartoons. In two developmental studies, only facial expression influenced judgments of friendliness-hostility in cartoons, but condemnation of aggression decreased as viewer age increased. Results with films of real children followed those for cartoons. Facial expression influenced judged aggressiveness, but only viewer age affected judged justifiability. Cross-experiment comparisons revealed that facial expression and the facial expression X real-cartoon interaction yielded major differences on both dependent variables. Subject and interactant gender were not significant for major dependent variables. Results of the developmental studies were similar to adults' suggesting that for judgments of simple aggressive acts, sex makes no difference, but facial expression does make a difference.

Adolescent↗