Selection of women at high risk of breast cancer using two lifestyle markers: a case control study.
OBJECTIVE: To select a population of women with high risk of invasive breast cancer by using two markers of high risk lifestyle--age at first delivery > = 25 and daily alcohol intake > = 7 g. DESIGN: Case control study based on a structural interview. SETTING: Two general practices in Copenhagen, Denmark. PARTICIPANTS: 30 patients with invasive breast cancer and 30 age-matched controls. MAIN OUTCOME MEASURE: The combined selection power of the two markers of high risk lifestyle. RESULTS: The combined selection power of the two markers was significant (P < 0.025, odds ratio 4.3, 95% CI 1.2-15.6). CONCLUSION: Using these markers it may be possible to select about 80% of all cases of invasive breast cancer in a high risk group comprising only 49% of the female population. This could be of importance for mammography screening; rather than unselectively screening all women in a given age bracket, it might be preferable selectively to screen only the high risk group.