Biomedical subjects

G G Grabenbauer

Publications and source records attributed to G G Grabenbauer.

56 records · Page 4Linked to original sources

PubMed1989

[Anal canal carcinoma: diagnosis--therapy--prognosis].

78 patients with anal canal carcinoma were treated between 1970 and 1988 at the University Hospital Erlangen. 48 patients (35 women, 13 men) were treated by surgery alone, 44/48 by abdominoperineal resection, 4/48 by local excision. Median age was 63 years, median follow-up 8.5 years. The overall local recurrence rate was 16.7%, the overall five-year-survival was 51%. 30 patients received a combined radio-chemotherapy. The small pelvis was treated with a.-p./p.-a. fields up to a total dose between 42 and 50 Gy. Two courses of chemotherapy consisting of 5-FU (800 to 1000 mg/m2 days 1 to 4 and 29 to 32) and Mitomycin C (10 mg/m2 days 1 and 29) were administered. Two months after completion of treatment 83% had a biopsy proven complete remission. After a median follow-up of 15 months 87% are alive with NED, 74% are continent. The combined regimen of radio-chemotherapy is considered as the treatment of the choice for anal canal carcinoma. Abdominoperineal resection is only performed in patients with non response or local recurrent disease.

Antineoplastic Combined Chemotherapy Protocols↗

PubMed1988

[Effects of fractionated irradiation of the rabbit eye. A histopathologic study].

The effect of fractionated 300 kV roentgen radiation on different sections of the eye (cornea, ciliary body, retina, and choroid) was investigated in 36 rabbits. Four groups of nine animals each were exposed to 21, 30, 36, and 45 Gy in constant fractions of 5 x 3 Gy per week. After three weeks, three months, and six months three animals from each group were killed. Both eyeballs, the eyelids, and the lacrimal glands were removed, fixed, and embedded in paraffin. The 15 sections made of each specimen were stained according to PAS and HE. The application of total doses of 21, 30, and 36 Gy did not lead to any histopathologically discernible alterations. Only in one animal was an ulcerating keratitis seen to develop within three months in response to a dose of 45 Gy. In the same group, a perilimbic conjunctival inflammation developed in three animals after six months and in two after three months. All animals which had received doses of 45 Gy and were examined after six months were found to have a vacuolic swelling of the ciliary epithelium. In one animal which had received a dose of 45 Gy a myointimal proliferation of a ciliary artery was seen three months after termination of the treatment.

Animals↗