[Experience in sample processing at a centralized biochemical laboratory].
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Biomedical subjects
Publications and source records attributed to G G Kharabuga.
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To discriminate initial stages of an inflammation from its destructive forms, the authors studied the leucocyte lysosome activity at different stages of inflammatory processes in abdominal organs. 90 patients and 30 practically healthy individuals were examined. The indices of acid and base phosphotase activity were found to rise together with the progress of an inflammatory process. A nomogram, permitting to determine with a rather high precision the stage and direction of the process, was made up on the grounds of the established reguliarity after the mathematical procession of the obtained figure data.
Separate estimation of intestinal and liver fractions of blood serum alkaline phosphatase in patients with acute forms of impairments corroborated the tissue specificity of these isoenzymes and showed the stable character of alterations in their activity at the initial steps of inflammatory-destructive processes in liver tissue, bile and intestinal tracts. The express methods for estimation of blood serum alkaline phosphatase isoenzymes enabled to carry out the examination within 1.5-2 hrs; the diagnostic methods may be widely used in urgent abdominal surgery.