Biomedical subjects
G G Mansharamani
Publications and source records attributed to G G Mansharamani.
Xipamide induced symptomatic severe hyponatraemia.
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Pharmacokinetics of aspirin in aged Indians.
The pharmacokinetics of aspirin (ASA) has been studied in elderly Indians (greater than 60 y) of either sex, composing, apparently healthy subjects controlled hypertensives and NIDDM diabetics, in comparison with healthy young subjects. Serum salicylate levels were estimated a 0, 0.5, 1, 2, 4 & 8 h after ASA. The pharmacokinetics of serum salicylate were not changed in elderly subjects as compared to the young after the first dose or after one week of ASA therapy, although greater variability was observed in the elderly. Various laboratory investigations were unaltered after one week in all the groups, except that one elderly hypertensive patient gained weight, and a young subject showed an increase in SGOT & SGPT.
Primary spinal epidural non-Hodgkin's lymphoma.
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Splenic abscess.
We report a splenic abscess in an elderly diabetic female. Awareness of the disease is emphasised.
Reply from authors. Praziquantel in neurocysticercosis.
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Cranial nerve palsies in benign intracranial hypertension.
Benign intracranial hypertension may occasionally be associated with various cranial nerve palsies. A case with multiple cranial nerve involvement is presented.
Hyponatremia in elderly hospital in-patients.
In a prospective study hyponatremia was observed in 30 per cent of 100 elderly hospital in-patients, the serum sodium ranging from 106 to 129 mmol/l. In 67 per cent of the subjects symptoms were absent or non-specific, and the remainder had symptoms of altered sensorium without any focal neurological deficit. Hyponatremia was iatrogenic in 30 per cent, while 17 per cent had an underlying bacterial chest infection. Removal of the cause rapidly reversed hyponatremia and the relevant symptoms. It is stressed that early detection and reversal of this abnormality would significantly limit morbidity in the elderly.
Mixed hepatoblastoma in a young adult.
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Praziquantel in neurocysticercosis.
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Non-drug therapy in systemic hypertension.
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Xanthomatosis and aortic stenosis (case report).
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