A51568A: N-demethylvancomycin.
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Anti-Bacterial Agents↗
Biomedical subjects
G G Marconi
Publications and source records attributed to G G Marconi.
Synthesis and characterization of a novel inhibitor of an aminoglycoside-inactivating enzyme.
A novel low-molecular weight inhibitor of an aminoglycoside-inactivating enzyme, initially isolated from fermentation broths of Streptomyces neyagawaensis, was determined to be 7-hydroxytropolone. Its structure was confirmed by synthesis. In vitro synergy was demonstrated between 7-hydroxytropolone and certain aminoglycosides against bacteria which were resistant to those aminoglycosides by virtue of a 2"-O-adenylyltransferase. The synthesis and characterization of some analogs of 7-hydroxytropolone is also described.
Anti-Bacterial Agents↗
A32390A, a new biologically active metabolite. II. Isolation and structure.
An inhibitor of dopamine-beta-hydroxylase, designated A32390A, was isolated from the culture broth of a Pyrenochaeta species. The inhibitor showed antimicrobial activity against fungi and gram-positive bacteria. Spectroscopic analysis and chemical degradation studies indicated that the structure was 1,6-di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol.
Animals↗
Silica gel chromatography of antibiotics.
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Anti-Bacterial Agents↗
The configuration of stendomycidine.
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Amino Acids↗
Configuration of the beta-methylaspartic acid residue in amphomycin.
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Anti-Bacterial Agents↗
The structure of stendomycidine.
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Antifungal Agents↗
On the N-methyl-L-threonine residue in stendomycin.
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Anti-Bacterial Agents↗