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Biomedical subjects

G G Pavlov

Publications and source records attributed to G G Pavlov.

14 recordsLinked to original sources
PubMed1990

[Chondroid tissue in the development of stromal components of the heart].

The chondroid tissue of the heart is an obligate provisional+ formation of the organ in question. It is formed during early stages of ontogenesis, develops maximally during the antenatal period and is preserved in the postnatal one. In a number of vertebrates it is the base for formation of cartilage and even bone in stroma of the heart. The ++chondroid tissue in embryos and fetuses performs, as regards the myocardium, stromal and trophic functions, further they are performed by the definitive connective-tissue stroma, in it vessels of the coronary system are situated. There are some reasons to suppose that the elements of the chondroid stroma are preserved during the postnatal ontogenesis in the myocardial intestinum, taking part in its metabolism.

Animals↗
PubMed1978

[Clinical x-ray and fibergastroscopic comparisons in the diagnosis of different forms of stomach cancer growth].

A radiological examination associated with fibergastroscopy was performed in 145 gastric cancer patients. All these patients were radically operated upon--extremely subtotal resection of the stomach was accomplished. The preoperative diagnosis of gastric cancer with both technics used simultaneously proved to be correct in 96.55%. However, the anatomical and ulcerous-infiltrative growth, especially in their cardiac and subcardiac localization are found to present the greatest diagnostic difficulties. The data obtained made it possible to believe that the detailed diagnosis of gastric cancer should comprise two steps--a radiological examination and fibergastroscopy.

Adult↗
PubMed1977

[Complex diagnosis of early forms of cancer of the large intestine].

The complex diagnosis of early forms of cancer of the large intestine should comprise the knowledge of the clinical picture, analysis of the disease, the results of rectoromanoscopy, irrogoscopy, colonofibroscopy, and cytological diagnosis. The use of the mentioned technics would help to improve the diagnosis of early forms of colonic cancer.

Colon↗
PubMed1976

[Radioisotope gastroscintigraphy in diagnosis of tumor and pretumor diseases of the stomach].

The results of isotope gastroscintigraphy, performed in 160 patients with tumor and pretumor diseases of the stomach, are reported. Based on a clinico-morphological estimation of gastroscintigraphic findings, it was found that in 115 (72%) patients the data of scanning coincided with the ultimate diagnosis. In 25 (16%) patients pseudopositive and in 20 (12%)--pseudonegative scannograms were obtained. The greatest number of pseudonegative results was noted in patients with gastric cancer (in 19 of 20), in 10 of them tumor being located in the cardiac portion of the stomach. The precision of diagnosing tumors in other anatomical portion of the stomach was 90%. In patients with pretumor lesions the character of scannographic alterations was dependent on the rate of impairment of gastric mucosa function and structure.

Adult↗
PubMed1975

[Ultrastructure of the skin in systemic scleroderma].

Biopsy specimens of the skin of the back of the forearm and hand in 20 patients with systemic scleroderma were studied using histological and electron microscopy methods. There were revealed evidences of intensified neofibrillogenesis, changes in collagen structures of the derma (destruction and defects of packing of collagenous fibrills, variability of their thickness in a fibre) and in the microcirculatory bed. In 18 out of 20 cases the nuclei of the connective-tissue cells and cells of the basal layer of the epidermis contained the so-called nuclear bodies, which are considered by a number of authors as an indirect evidence of a viral infection. The process of an intensified neoformation of collagen fibrils considerably predominated over destructive processes in collagen structures.

Adult↗
PubMed1975

[Morphologic changes in the chorio-allantoic membrane and organs of chick embryos inoculated with blood of patients with systemic lupus erythematosus (concerning the viral etiology of systemic lupus erythematosus)].

Morphological studies of 14 chorionallantoic membranes and organs of chick embryos which had been infected on the 7--8th day of incubation with leucocytic mass from patients with systemic lupus erythematosus were carried out. Corresponding virological and morphological control studies were performed. The changes observed were repeatedly reproduced in multiple inoculations (from the 2nd to the 16th passage). Apart from morphological changes, which may be listed among general pathological processes (impairment of the circulation, dystrophy, proliferation), changes testifying to a possible cytopathic effect disintegration of nuclei, formation of gigantic cells and multinuclear symplasts were also noted. The most pronounced changes, both in the chorionallantoic membrane and in internal organs, were observed on the 3rd--5th passage and on the 3rd--5th day of incubation following inoculation. They correlated with the clinical activity of the process in patients from whom the blood for inoculation had been taken. The data obtained justify the assumption concerning the existence in the blood of the patients with systemic lupus erythematosus a transplantable agent producing a cytopathic action, and may be considered as a new indirect corroborative evidence in favour of the concept of the viral nature of systemic lupus erythematosus.

Animals↗
PubMedDate not supplied

[The stromal components of the heart: their development and structural and functional characteristics].

Concepts of the structure, function and development of stromal components of the heart based on the author's studies and the literature data are discussed. The presence in the heart of stromal components of two generations (provisory and definitive) developing from different embryonic rudiments in suggested. Histogenetic processes of the stromal development at early stages of heart organogenesis are described. A detailed description of chondroid provisory tissue and sinusoidal vessels ensuring stromal and trophic functions with respect to muscular elements of myocardium is provided. A comparative characteristic of chondroid tissue and cartilage is given. Attention is given to stromal components which, being derivatives of the provisory stroma, are present in the heart of humans and vertebrates, constituting an obligatory part of the united connective tissue stroma and blood supply system of the heart. An original scheme is proposed reflecting general pattern of the development and interaction of stromal heart components of two generations, having different sources of origin. Observations supported by an original scheme are made regarding the place of stromal heart components in the system of supportive structures of the organism. Organ specificity of heart stroma is supposed to be a basis for using aortal-valval complex of pigs as bioprostheses in modern cardiac surgery.

Animals↗
PubMedDate not supplied

[Specific nature of the development of myocardial blood vessels as one of the conditions of compensatory cardiac reserves].

The mechanism responsible for the formation of cardiac connective tissue and vascular components in early ontogenesis from various embryonal layings and the subsequent coexistance and interaction of two myocardial blood supply system in the formed heart at all stages of postnatal life form the basis for morphological and functional characteristics of organ specificity. The findings are of direct interest to practical cardiologists and cardiosurgeons who analyze some conditions which are likely to involve compensatory mechanisms in inadequate coronary blood supply of the heart.

Adaptation, Physiological↗