1. Under specified experimental conditions the distribution space of labelled chylomicrons in the kidney was 13.8 +/- 0.9 ml./100 g. tissue. The assumption is supported that this provides a measure for the quantity of intravascular plasma constituents.2. Values for red blood cells and albumin distribution spaces were 5.2 +/- 0.6 and 20.2 +/- 1.0 ml./100 g tissue, respectively, in the whole kidney. The ratio of tissue haematocrit over simultaneous arterial haematocrit averaged 0.56. The extravascular albumin fraction amounted to about 31.0% of the total albumin in the whole kidney.3. A statistically significant correlation was demonstrated between osmotic urine/plasma (U/P) ratios (within the approximate limits of 0.6-1.8) and quantities of extravascular albumin in the medulla.

Animals↗

PubMed1967

Effects of pH and urea concentration on uptake of fluid and urea by solutions containing serum albumin.

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Biological Transport↗