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G G Prokhorov

Publications and source records attributed to G G Prokhorov.

22 records · Page 2Linked to original sources
PubMedDate not supplied

[An evaluation of the results of intra-arterial injections in treating chronic ischemia of the lower extremities].

Intra-arterial infusions used in treatment of ischemia of lower extremities in patients with obliterating atherosclerosis can cause pronounced vasoconstrictory reactions in distal parts of the extremity with reduced pulse blood filling and oxygenation of tissues. As necessary measures of prophylactics of negative shifts in regional blood circulation the author suggests to be valuable anesthesia and atraumatic character of interventions, use of warm solutions, exclusion of irritating drugs and osmotically active substances. The final efficiency of intra-arterial infusions is dependent on the observation of the above conditions.

Arteriosclerosis Obliterans↗
PubMedDate not supplied

[A method of redoxometry in clinical studies].

Direct estimation of redox-potential in human skin and muscles using platinum electrodes enables to carry out dynamic evaluations of redox-state in these tissues. A similar technique might be used for potentiometric measurement of the rate of local tissue circulation using hydrogen clearance. Increase in the electrodes sensitivity, required for studies of circulation severe impairments, was possible by means of additional platinum overlaying. Examination of patients with obliterating atherosclerosis showed a considerable decrease of redox-potential in ischemic zone; this impairment was partially reduced after surgical operation. The validity of alterations in electrode potential was supported by means of oxygenometry, blood pH-metry and rates of tissue circulation measurements. Interpretation of the data obtained is limited due to requirements of obligatory functional loading and theoretical considerations. However, the procedure of electrode potential registration allowed to obtain an information essential for choice of suitable treatment course.

Arteriosclerosis Obliterans↗
PubMedDate not supplied

[The results of the drug therapy of the ischemic syndrome in arteriosclerosis obliterans].

A thorough investigation of 120 patients with obliterating atherosclerosis of lower extremities, treated conservatively at a hospital and observed for 5 years have shown that such a treatment was most effective in patients with the initial stages of the disease. The mechanisms of positive effects is based on the dilatation of the peripheral arteries and the resulting decrease of the peripheral resistance of the vessels, improved cardiac activity, activation of microcirculation and tissue respiration. An important result of the treatment is an increased rate of the oxygen consumption by the tissues in the ischemic zone. It determines the pathogenetic direction of the therapy which leads to a delayed progress of the disease in 20% of the patients and improves the patient's state in 57% of cases.

Adult↗