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Biomedical subjects

G G Radzivil

Publications and source records attributed to G G Radzivil.

At least 19 recordsLinked to original sources
PubMed1990

[Acute rise of intracranial pressure--one of the causes of disorders of systemic circulation in meningococcal lesions of the central nervous system].

Tetrapolar chest rheography was used to study the central hemodynamics in 110 patients with meningococcal meningitides. Of these, in 86 patients, meningitis was combined with coccemia. The hyperkinetic type prevailed with a simultaneous decrease of the rate of the normo- and hyperkinetic types as compared with the distribution of the circulation types in healthy persons. It has been shown that the main cause of the development of the hypokinetic type of circulation manifesting itself in the rise of the total peripheral resistance and lowering of myocardial contractility lies in acute rise of intracranial pressure at the expense of the development of acute hydrocephalus and/or brain edema. Favouring intracranial pressure reduction decompression of the subarachnoidal space by lumbar puncture brings about a decline of the peripheral resistance, i.e. of afterload, and a rise of myocardial contractility. Detoxication and therapy of brain edema with the aid of the hypervolemic version of forced diuresis performed by means of intravenous injection of hyperosmotic solutions (rheopolyglucin, concentrated solutions of albumin, glucose) at a rate of 100 ml within 30 to 40 minutes promote the growth of intracranial pressure, elevation of the peripheral resistance and reduction of myocardial contractility.

Acute Disease↗
PubMed1990

[Characteristics of blood circulation disorders in meningococcal meningoencephalitis].

Studies of liquorologic, hemodynamic, electrophysiologic, and biochemical characteristics of the blood, carried out over the course of the disease in 110 patients with purulent meningoencephalitis of meningococcal etiology, complicated by development of high intracranial hypertension, have revealed a hypokinetic type of circulation, characterized by reduced heart performance and elevated afterload, in the majority of the examinees during the acute period of the disease. Among the causes contributing to the formation of the hypokinetic type are inflammatory and dystrophic changes in the myocardium, deterioration of the blood rheology (of the high blood viscosity syndrome type), and vasopressor effect of elevated intracranial pressure (Cushing's phenomenon) resultant from brain edema developing in the majority of patients. The findings evidence the leading role of intracranial pressure elevation in the origin of increased tone of resistive vessels and in the development of macro- and microcirculatory disorders in the acute phase of the disease.

Adolescent↗
PubMed1989

[Diagnosis of cardiac lesions in the generalized form of meningococcal infection].

Activity of the enzymes indicating heart affection in the acute period and in disease dynamics was increased in 97 patients with generalized forms of meningococcal infection. Signs of cytolysis, according to the data of enzymatic blood examination, were revealed to the utmost degree in patients with typical complications of meningococcal infection--brain edema, which persisted for 10 days of the disease. Herpetic infection joins twice as often in patients with brain edema and is accompanied by a pronounced cytolytic component in the myocardium and liver. Infectious cardiopathy as compared to other complications is characterized by a longer period of hyperenzymemia and the increment of the enzyme activity is greater in the acute period.

Adenylyl Cyclases↗
PubMed1989

[Enzymologic diagnosis of cerebral lesions in generalized forms of meningococcal infection in the acute period].

Cerebrospinal fluid was tested for several enzymes (CPK, AST, GGTP, BP, BG, AK) in 97 patients with generalized meningococcal infection with prevalent CNS affliction. Marked changes were detected even in the absence of clinical signs of cerebral lesion that was typical only of meningococcemia. Nevertheless, most pronounced changes were observed in a group of patients with cerebral edema and swelling. The changes in cerebrospinal fluid enzyme levels coincided with a reduced glucose and increased protein contents. In these cases, CSF hypertension increased CSF pressure to maximal levels. Most informative indices were singled out and their levels characteristic of acute phase of the disease established.

Adolescent↗
PubMed1989

[Study of cardiac function in generalized meningococcal infection based on various biochemical indicators].

The complicated course of meningococcal infection is distinguished by a long-term increase in the level of aspartate transferase and creatine phosphokinase. There were three types of changes in the activity of creatine phosphokinase, while changes in the activity of aspartate transferase were not so diverse. Patients had isolated as well as combined increase in the activity of both these enzymes. Lipid peroxidation was also augmented which corresponded to changes in the level of aspartate transferase. The high level of enzymes in the blood in meningococcal infection is the result of cytolysis as well as myocardial hyperfunction in the acute period of the disease.

Adult↗
PubMed1989

[Hemosorption in infectious pathology].

Hemosorption was used for the treatment of 152 patients with purulent meningitis, sepsis complicated by shock, virus hepatitis and leptospirosis. A favorable effect of hemosorption in infections was based on highly effective correction of microcirculatory disorders as a result of the removal of high molecular substances of microbic and endogenous origin.

Hemoperfusion↗
PubMed1988

[The enzyme diagnosis of liver involvement in meningococcal infection].

A complex of blood enzymes (AST, ALT, AP, GTT) was studied in 84 patients with generalized forms of MI. The study showed that signs of liver involvement were noted in 15.4% of the patients on the 1st day of disease. Laboratory signs of cytolysis and cholestasis were revealed in most examinees on the 7th-15th day of disease during a dynamic follow-up. The most noticeable syndromes were revealed in young patients (30 persons) with brain edema (42.2%). Primary liver involvement (i. e. noted on admission to hospital) in 6 patients was associated with MI toxic effects, in 7 patients--with a severe concomitant pathology of the pulmonary and cardiovascular system. Delayed liver involvement was detected in 55.3% of the young patients and in half of the elderly patients. It was established that a course of disease was accompanied by the affection of many organs from the first days complicating the interpretation of enzymological data therefore requiring combined enzymological investigations.

Adolescent↗
PubMed1986

[Role of hemosorption in the therapy of infectious toxic shock and the multiple-organ failure syndrome in a fulminating form of meningococcemia].

Hemoperfusion was applied to the treatment of 20 patients with fulminant meningococcemia complicated by the infectious-toxic shock, stage III, and the polyorgan insufficiency syndrome. Ten patients recovered while the remaining 10 died mainly because of irreversible lesions of the vitally important organs: kidneys, adrenals, heart and brain. In the deceased patients, the prehospital stage had lasted two times longer than in the convalescents. All the patients had received antishock therapy: correction of acidosis, artificial ventilation of the lungs, dopamine, pharmacological doses of steroids and protease inhibitors as well as moderate infusion therapy. Hemoperfusion was instituted immediately after elimination of arterial hypotension. The use of hemoperfusion promoted the abatement of systemic toxicosis and neurotoxicosis, the recovery and stabilization of the hemodynamics, improvement of rheological properties of the blood, the recovery of effective tissue perfusion, the lowering of specific antigenemia and blood toxicity, and elimination of the pathological protein complexes from the circulating blood.

Adolescent↗
PubMed1984

[Rheologic disorders in myocardial infarct complicated by acute left ventricular failure].

Thirty-six patients with acute myocardial infarction aggravated by acute left ventricular failure (pulmonary edema, cardiogenic shock) were studied for their blood rheologic properties. The impairments of the blood rheologic properties were classified as Stage I and II syndromes of high and low blood viscosity and were characterized by a phasic nature of their course. The rheologic disorders associated with pulmonary edema and reversed cardiogenic shock were decompensated (Stage II syndrome of high blood viscosity--Stage I syndrome of low blood viscosity), but reversible following intensive rheologic therapy. Irreversible cardiogenic shock was characterized by Stage II syndrome of low blood viscosity which was intractable. In acute myocardial infarction without concomitant acute left ventricular failure, rheologic disorders were characterized by Stage I syndrome of high blood viscosity, i. e. they were compensated and did not require intensive rheologic therapy. The management of rheologic impairments attending acute left ventricular failure should be combined, the intensity of therapeutic measures, the nature of combinations and the dosage of drugs being dependent on the degree and phase of rheologic disturbances.

Acute Disease↗
PubMed1984

[Changes in the rheologic properties of blood in septic shock].

Results of examination of rheological properties of blood in 62 patients with septic shock of peritoneal etiology are presented. The control group included 50 patients with diffuse peritonitis without manifestations of septic shock. In patients with favourable outcomes of the disease septic shock was accompanied by the development of the high blood viscosity syndrome of the IInd degree or low blood viscosity syndrome of the Ist degree when microcirculatory and thrombohemorrhagic complications were of a reversible character. Irreversible septic shock was associated with the low blood viscosity syndrome of the IInd degree with a developing hypocoagulopathy of consumption when the therapeutic methods failed to correct rheological and microcirculatory disorders. Attention is called to differentiated approach to the treatment with special reference to the degree and phase of the rheological disorders.

Adult↗
PubMed1981

[Clinical pathophysiology and intensive therapy of diffuse peritonitis].

The work describes the results of an investigation of pathophysiological shifts and methods for their correction used in 204 patients with diffuse peritonitis. It is concerned with problems of diagnosis and therapy of protein, water-electrolyte disorders, acute respiratory insufficiency, "shock lung". Pharmacodynamic and pharmacokinetic properties of cephalosporins injected intravenously and intra-orally were studied. With antibiotics used as an indicator, the disturbances of processes of mixing and shunting the blood were revealed. The authors believe that patients with diffuse peritonitis should be subjected to intensive therapy under conditions of a reanimation department during 5-12 days.

Adult↗