PubMed Health⌕ Search

Biomedical subjects

G G Tatishvili

Publications and source records attributed to G G Tatishvili.

At least 19 recordsLinked to original sources
PubMed1995

[Evaluation of abdominal treatment with magnetite suspension in peritonitis].

The work discusses the results of the effect of intraoperative treatment of the abdominal cavity with a magnetite suspension on the T-cell link of the immunological reactivity of the organism of patients with diffuse forms of peritonitis. The preparation intensified lymphocyte proliferative activity. It was found that increase of the lymphocyte stimulation index in intraoperative treatment of the abdominal cavity with magnetite suspension in peritonitis was consequent upon increased production of interleukin-1 and other growth factors by macrophages.

Contrast Media↗
PubMed1991

[Disorders of organic hemodynamics of the liver and their correction in suppurative cholangitis].

The blood flow in the portal vein and hepatic artery was studied by means of ultrasonic Doppler flow measurement to investigate organic and regional hemodynamics of the liver in purulent cholangitis. The blood flow in the portal vein was found to be significantly diminished in patients with acute cholangitis and hepatic failure. Hepatic microcirculation was studied on a experimental model of obstructive jaundice and obstructive purulent cholangitis in rats by polarographic measurement of hydrogen clearance. Considerable reduction of the volume rate of the local blood flow was noted, and the degree of the reduction was related to the severity and duration of the disease. Decompression of the biliary tract by external drainage improved the local blood flow rate which, however, diminished again in prolonged external drainage. The use of pharmacological agents for correction of microcirculation in decompression of the biliary tract led to total and rapid correction of the volume rate of the local blood flow.

Acute Disease↗
PubMed1990

[Correction of chronic disorders of duodenal patency in the prevention of postoperative complications of peptic ulcer].

Experiments on dogs demonstrated the role of chronic disorders of duodenal patency (ChDDP) in the development of immediate and late-term postoperative complications of gastric and duodenal ulcer, like incompetence of the duodenal stump, reflux gastritis, progression of duodenostasis existing before the operation, the afferent loop syndrome, postresection cholecystitis and pancreatitis, the dumping syndrome. The formation of valvar anastomoses and early recognition and correction fo ChDDP in resection of the stomach (554 patients) made it possible to reduce significantly both the mortality rates (0.18%) and the percentage of other complications.

Afferent Loop Syndrome↗
PubMed1990

[Prevention of duodenal hypertension after gastrectomy].

Based on an analysis of outcomes of gastric resections for ulcer disease in 825 patients and experimental investigations the authors consider that the main cause of incompetence of the duodenum stump is stagnation of contents in the duodenum. For the prevention of this complications the Billroth-II resection with transverse (valvular) enteroanastomosis is recommended.

Animals↗
PubMed1989

[Treatment of the abdominal cavity with a colloid solution of magnetite during surgery in experimental ichorous peritonitis].

Experimental investigations gave grounds for the possibility of using the solution of colloid magnetite for the treatment of the abdominal cavity during operation for peritonitis. It was established that the substance has good bacteriocidal and bacteriostatic properties, adsorbs toxic substances present in the peritoneal exudate, is absorbed into blood from the abdominal cavity, does not destruct the cytostructure of the cells of formed elements of the blood, and is easily eliminated from the organism with the bile.

Animals↗
PubMed1985

[Genetic problems of hereditary polyposis of the large intestine. I. An analysis of the interrelation with intestinal cancer].

An attempt has been made to estimate the correlation of oncological illnesses in the families within the limits of segregational and correlational analyses, considering the fact of accumulation in the families of probands with autosomal-dominant polyposes of colon of the cases of primary (without preceding polyposes) colon cancer. Significant correlation was found between the hereditary polyposes and primary colon cancer in the families studied. Based on these data, a hypothesis is discussed of the main gene and its modifications on the phenotypical version in the form of primary benign (polyposes) and malignant (cancer) pathology. No significant correlation was found between colon polyposes and cancer of stomach in the families.

Genetic Techniques↗
PubMed1985

[Enteral tube feeding after planned operations on organs of the abdominal cavity].

The enteral probe feeding was used in 60 patients operated on organs of the abdominal cavity in planned order. The individual nutrition media were composed with special reference to metabolic disorders and the functional state of the gastro-intestinal tract. It helped to make an adequate correction of metabolic disorders and facilitated early normalization of motor activity of the gastro-intestinal tract.

Abdominal Neoplasms↗
PubMed1985

[Principle of plotting the age distribution of persons with hereditary diseases at various ages of onset and differential mortality].

A method for ascertaining the mode of current age distributions is suggested for accurate quantitative assessment of some genetic parameters of hereditary diseases, such as age-specific penetrance, frequency of heterozygotes in the general population, fitness. The method is based on estimating the age-specific proportion of affected among the total number of heterozygotes, which seems more reasonable than the common methodology, considering the age-specific proportion of affected among all cases of the disease indicated.

Age Factors↗
PubMed1984

[Analysis of the relation of the frequency of new gene mutations for Mendelian diseases to parental age].

The effect of parental age on mutation rates of achondroplasia, neurophibromatosis, hereditary gastrointestinal adenomatosis and Duchenne muscular dystrophy loci was studied. A significant parental age effect on the occurrence of new mutations for achondroplasia and neurophybromatosis was shown. The paternal component of this parental age effect was the major factor in the occurrence of such mutations. The risk of the occurrence of new cases of achondroplasia and neurophybromatosis, as compared with their overall frequency, due to new mutations, are increased by a factor of 2 and 3, respectively, up to the paternal age of 50. The possibility of application of the data obtained in genetic counselling is discussed.

Female↗