Biomedical subjects
G Gómez Agudo
Publications and source records attributed to G Gómez Agudo.
[Leucocyte chemotaxis in patients treated with chronic haemodialysis (author's transl)].
Granulocytic and monocytic chemotaxis are studied by means of Boyden's modified method using as chemotactic agent human serum complement activated by Zymosan. The study has been made on healthy controls and a group of patients suffering from chronic renal failure treated with periodic haemodialysis. Observations were made before and after the dialysis session. In the patients with chronic renal failure is observed a decrease in leucocytic mobility of granulocytes and monocytes which give chemotactic granulocytic and monocytic indexes of 32.1 +/- 3.1 and 32.3 +/- 3.5 with relation to healthy controls with indexes of 46.7 +/- 8.4 and 37.0 +/- 4.3 and with significative differences between the measurements of p less than 0.001 and p less than 0.005 respectively. The parametres of polymorphonuclear and monocytic kinetics did not improve after the haemodialysis session. The possible mechanisms which produce such chemotactic leucocytic deficit in uraemics and the non-positive influence of the dialysis session on such deficit are hereby discussed.
Serum prolactin and thyrotrophin responses to thyrotrophin-releasing hormone at different times of the day in normal women.
In order to determine whether or not the pituitary responsiveness to thyrotrophin-releasing hormone (TRH) changes during the nyctohemeral cycle, 10 healthy regularly cycling women were given 200 microgram of TRH at 02.00 h, 10.00 h and 18.00 h with at least a 32 h interval between each test. Serum prolactin (Prl) and thyrotrophin (TSH) in 7 of the 10 women were measured serially before and after TRH administration. The mean basal Prl levels were significantly higher (P less than 0.01) at 02.00 h than at 10.00 h and 18.00 h. The mean basal TSH levels were higher, although not significantly, at 02.00 h than at 10.00 h and 18.00 h. Although a higher TSH release occurred at 02.00 h than at 10.00 h and 18.00 h, the mean serum TSH and Prl peak responses to TRH were statistically similar in the three groups of tests. The integrated changes scores, calculated as the difference between the average post-TRH hormonal release and the average baseline levels, although higher in the 18.00 h test for Prl and the 02.00 h test for TSH, were not statistically different among the three tests.
[Bisalbuminemia and pseudobisalbuminemia: clinical significance (author's transl)].
Two cases of bisalbuminaemia are hereby studied: a congenital case and an acquired or transitory case. In the first one, this hereditary disturbance is studied on four affected members of one Spanish family, being associated in two of them with multiple lipomatosis. This kind of association is considered as casual. As in most of the informed cases, ours belongs to the slow kind. The second case deals with a bisalbuminaemia of transitory character or pseudobisalbuminaemia which, appeared in a woman in the course of an acute pancreatitis of biliolithiasic origin, with a pancreatic pseudocyst and pleural effusion, the evolution in the inflamatory pancreatic process being advantageous in spite of the prsence of bisalbuminaemia. Briefly revised, are exposed the causes of this interesting and rare alteration in the electrophoretic fractioning of plasmatic proteins: congenital, and adquired causes due to administration of betalactamines and during the course of acute pancreatitis.