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Biomedical subjects

G Görlach

Publications and source records attributed to G Görlach.

44 records · Page 3Linked to original sources
PubMed1977

[Intraoperative measurements of prognostic value in coronary bypass surgery (author's transl)].

The effect of an aortocoronary bypass graft on coronary hemodynamics was studied experimentally in dogs and during surgery for aortocoronary bypass grafting in man. In the experimental part of this study it was shown that coronary dilatory reserve is unaffected between 0 and 50% coronary narrowing. In the presence of more severe stenosis the dilatory reserve declines rapidly. Competition of flow between an aortocoronary bypass graft and the stenotic segment is related to the degree of coronary stenosis. In 53 patients graft flow was measured during surgery. The relation between hyperemic response (hyperemic/control flow = HR) after short occlusion of the graft and the poststenotic coronary pressure (poststenotic pressure/aortic pressure times 100 = PSPR) could be described by the function HR = a. exp b PSPR (r = 0,87). When the degree of coronary stenosis exceeded 80% narrowing, poststenotic pressure decreased rapidly and hyperemic response appeared. In patients with comparable LAD stenosis a close correlation was found between basal graft flow and anterior wall motion (r = 0,91). It is concluded that graft function can be evaluated by the relation between HR, PSPR and the degree of coronary stenosis. Left ventricular wall motion is shown to be an additional determinant of graft flow.

Animals↗
PubMedDate not supplied

Preservation of high energy phosphates in hypertrophied human myocardium.

Hypertrophied hearts are extremely vulnerable to ischemia. In 61 patients with aortic valve disease undergoing surgery we investigated the quality of myocardial protection obtained with three different methods of crystalloid cardioplegia. To exclude the influence of temperature differences the regional myocardial temperatures were continuously measured and adjusted to the same level in all patients. Before and after ischemia and after 10 minutes reperfusion myocardial biopsies were taken and the high energy phosphates and lactic acid determined. In one group St. Thomas cardioplegia was used, in another Bretschneider cardioplegia and in the third the Hamburg method. There were no significant differences between the three groups at the end of ischemia and after 10 minutes reperfusion. After 10 minutes reperfusion the metabolic alterations caused by ischemia were in part reversible. From our results we conclude that each of the cardioplegias used is able to protect a hypertrophied heart adequately against ischemia during cardiac arrest.

Adenosine Diphosphate↗
PubMedDate not supplied

Myxoma of the aortic valve in a child.

Myxomas are predominantly located in the right on left atrium. We report an unusual case of a myxoma adherent to the aortic valve. The child presented with symptoms of subaortic stenosis. By invasive methods a tumor was diagnosed located at the aortic valve. After surgical removal the child recovered soon and is doing well. According to our knowledge this is the first report of a myxoma of the aortic valve.

Aortic Valve↗
PubMedDate not supplied

Surgical therapy of pulmonary thrombosis due to candidiasis in a premature infant.

We report a case of surgical removal of a pulmonary thrombosis in a premature infant with candidemia. The pulmonary thrombotic material contained candida albicans. Following surgical therapy the child recovered soon and candidemia did not recur. We conclude that surgical treatment of pulmonary thrombosis can be successfully done even in premature infants.

Candidiasis↗