Biomedical subjects
Publications and source records attributed to G Götz.
Fibrofolliculoma is a rare tumor of the perifollicular mesenchyma. A 44-year old man noticed a growing number of small whitish firm papules on his neck and the upper thorax over the past two years. Histological examination demonstrated on multiple biopsies typical features of fibrofolliculoma. Further evaluation of the patient has not revealed any sign of neoplasia. The variable clinical manifestations of fibrofolliculomas are discussed.
The teaching of odontotechnology at the University of Budapest has a more than 100 years history. It was started in the Academic Dental Institute led by József Arkövy. The first lecturer and practice instructor was Lajos Hattyasy. The first Institute of Odontotechnological Research was established in 1900, and was headed by the first "private docent" of the World appointed in Odontotechnology, Lajos Hattyasy. The Clinic of Stomatology in Budapest was opened in 1909 with European standard dental laboratory and practice rooms. The training program was extended to six semesters according to the act of the 1924 and 1936 Law of Education. In addition to odontotechnology the courses of dental materials and metals as well as restorative dentistry became independent preclinical subjects with a total of 670 teaching hours, making up 17% of the whole dental curriculum. That time Henrik Salamon and Dénes Máté were the chief lecturers. After World War II a new type of dental education started in 1952. The curriculum was extended to 10 semester with a great emphasis on odontotechnology. A very modern, phantom head preclinical training laboratory was opened in 1953. The total teaching time of odontotechnology was 360 hours and its theoretical principles were summarized in Hungarian second generation textbooks. That time Imre Földvári and György Huszár were the chief lecturers. From 1965 the significance of the course of odontotechnology was gradually diminishing and the teaching hours were markedly reduced. In 1967 odontotechnology as an independent subject was ceased and integrated into the prosthodontic dentistry. Its teaching time was reduced to 120 hours. In 1996 odontotechnology parallel with other preclinical subjects became independent again and earned a total of 260 teaching hours in the dental curriculum.
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Authors investigated the possible relationship between different types of ponties and the development of dental plaque. Microbiological examinations revealed, that keeping to the strictest hygiene rules, even the least proposed saddle ponties should be omitted. Attention is called to the utmost importance of motivation and instruction in case of patients wearing bridges.
Between 1983 and 1991 the Philadelphia chromosome (Ph1) was found in bone marrow and/or peripheral blood cells of 25 adult patients with acute lymphoblastic leukemia (ALL). The Ph1 as sole anomaly was seen in 13 patients, while six patients had additional structural and another six structural and numerical aberrations. Most patients (23/25) received combination chemotherapy according to the BMFT protocols 1/81, 2/84, 3/87, and 4/89. For 25 evaluable patients two early deaths, two treatment failures, two partial remissions (PR), and 19 complete remissions (CR) after phase 1 or 2 of the induction regimen were recorded. Two of these 19 patients who achieved CR are presently disease free, whereas 17 have relapsed after a median duration of remission of 9 months. Actuarial median survival for all patients was 13 months. The probability of continuous complete remission (CCR) after 39 months, as well as that of survival after 40 months, is only 6%. Our results confirm that the presence of the Ph1 is associated with a poor prognosis in adult-ALL patients. Therefore, whenever first CR is obtained and an HLA-identical donor is available, allogeneic bone marrow transplantation (BMT) should be performed at once, the more so, since transplantation in second CR seems to offer no cure. Future studies will have to show whether an intensified cytotoxic therapy can improve the prognosis of Ph1(+)-ALL.
This study was designed to determine vertical deviations in mounting casts on an articulator as affected by the recording material. Five different recording materials were tested after storage of the records for 30 minutes, 6 hours, and 24 hours. Two measuring systems were used to register simultaneously the vertical errors at the occlusal plane and at the condyle of an articulator. The results indicated that the measurements made at the condyle cannot detect the vertical deviations induced at the occlusal surfaces. None of the materials tested gave reliable results. Advantages, disadvantages, and indications of the different materials were discussed.
In everyday practice hitherto used embedding masses permitted so to say but the making of shrinked castings. On basis of experiments performed with embedding masses (Bellavest, Castorit C) prepared for precious-metal-free alloys recently marketed it has been ascertained that exact castings can be prepared from moulds embedded therein if technical discipline is observed.
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An experimental study was conducted to analyze the accuracy of transferring jaw relations with recording materials and the derived casts. A specific measuring system was designed to determine three-dimensional deviations of the condyles of an articulator. Four interocclusal recording materials were analyzed after various storage periods. The results indicated that the accuracy of the derived cast had a critical influence on the accuracy of the transferred jaw relations. None of the materials were reliable; the most accurate material generated deviations of approximately 300 microns.
A specific testing system was used to determine the three-dimensional changes of interocclusal registration materials for a simulated patient and the derived stone casts. The results indicated that the deviations of the derived casts were more pronounced than the original models. There was great heterogeneity with all recording materials and the materials were not consistently accurate after limited storage of 30 minutes.
An experimental study was conducted to determine the three-dimensional errors in mounting casts affected by the interocclusal recording materials. Eight commonly used materials or combinations were tested after various storage periods. The results indicated that all the materials induced asymmetric deviations of the condyles after each storage period. Impression plaster was the most accurate and dimensionally stable material; polyether was the second most accurate material, but it must be used within 6 hours. Correction of the teeth imprints with a low-viscosity material was beneficial only in combination with wax wafers.
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The 2-cyanaziridines Ciamexone and Azimexone in doses of 100 and 500 mg/kg lead to a reversible dose-dependent formation of thermolabile hemoglobin and Heinz bodies, a lowered erythrocyte count, and splenomegaly. According to our investigations these effects may have been caused by a covalent binding of the 2-cyanaziridines or their metabolites to globin in the erythrocytes. This binding was shown by gel electrophoresis using 14C-labeled Ciamexone. The change of the globin had no influence on the oxygen affinity of the hemoglobin.
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