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Biomedical subjects

G Gagliardi

Publications and source records attributed to G Gagliardi.

12 recordsLinked to original sources
PubMed1992

Radiation therapy of stage I breast cancer: analysis of treatment technique accuracy using three-dimensional treatment planning tools.

This paper presents the routine implementation of a method for use of three-dimensional (3-D) treatment planning for breast cancer patients with node negative disease, treated with breast conserving surgery. The patients were positioned on a device which fitted a CT aperture with a diameter of 70 cm. A patient reference system was defined by the mamillary plane and the sternum midline. Eight to twelve CT images per patient were taken. The target volume was defined in several CT slices. The treatment planning was made with a 3-D treatment planning system; the treatment technique was isocentric with tangential fields. The patient position was the same at the CT scanner and during the treatment. Four to six portal films per field per patient were routinely taken. The reproducibility of the set-up was investigated on 20 consecutive patients: the treatment-to-treatment variation results were related to the margin of the target. The comparison between treatment planning and portal films gave information about the isocenter displacement. No large discrepancy between measurements on simulator film and on portal films was found. Based on the presented results the described treatment technique has been introduced as part of a routine clinical practice at our institution.

Breast Neoplasms↗
PubMed1990

Rehabilitation of children after total correction of tetralogy of Fallot.

Nine children who had undergone total correction of tetralogy of Fallot were studied with the purpose of observing the physical changes that might be produced by a period of rehabilitation in hospital and comparing these results with those of a control group having the same pathology but which had not followed a protocol for physical activity. Precise criteria were used in the selection of the patients. Careful clinical examinations and exercise tests were conducted before and after the programme, in particular maximal stress testing on the bicycle ergometer and submaximal exercise on the treadmill. The sessions were held three times weekly in a gymnasium over three months, gradually increasing the duration of each session to a maximum of one hour. During the session, heart rate was monitored with a Sport-tester 3000 so as not to exceed 60%, then 70%, of the maximal heart rate recorded during the stress test. Testing at the end of the programme demonstrated an improvement in tolerance under maximal stress in 7 of the 9 patients. As for submaximal performance, 8 out of 9 children covered a greater distance using the same parameters as for initial testing. At the end of the programme, the children all showed increased independence and initiative and more self-confidence in establishing social relations. The programme has proven to be a comprehensive method for safely improving physical fitness in these patients and represents an important starting point for a better future.

Child↗
PubMed1976

New media and their advantages in the production of suspended cells and foot--and--mouth disease virus.

The problems related to the use of serum in cell culture are reviewed. The possibility of substituting the serum with peptones has already been shown. Different peptones have been tested: one of the best is a peptone obtained from meat and casein pepsin pancreatically digested. BHK 21/13 cells were cultivated in serum-free media for 35 passages. The 0.81 cultures without automatic pH control had a cycle length of 3 days; starting with concentrations of 0.4 X 10(6) cells/ml, concentrations higher than 3 X 10(6) cells/ml were often obtained. We did not obtain satisfactory results when the volume of cultivation was increased to more than 6 1, perhaps because of different requirements for agitation, pH, O2. It is also necessary to check whether the results obtained up to now are consistent with reference to the source of reagents and cell strain used. The absence of serum in the medium did not influence virus replication when infectivity and complement fixation titers were tested.

Aphthovirus↗
PubMedDate not supplied

[Lateral sliding flaps in mucogingival surgery].

Reference is made to parodontal surgery techniques employing lateral sliding flaps mucogingival for the treatment of gingival schisis. Grupe & Warren (1965) proposed the use of a flap from the parts contiguous to that affected by the schisis. The technique was then developed by the introduction of bipapillar flaps and a flap taken from a toothless saddle. All operations using sliding flaps form part of the most difficult area in mucogingival surgery, due to difficulty of securing the "taking" of the flap on the root cement of the parts affected by schisis.

Gingivitis↗
PubMedDate not supplied

[Free gingival graft in mucogingival surgery].

Palatine grafts, which today represent the simplest and most reliable technique for enhancing the adherent gum--a problem of great importance in periodontal treatment--are discussed together with other techniques designed for the same purpose. Bone site palatine grafts which restore adherent gum on the alveolar bone, are distinguished from osteo-dental site grafts which are proposed for the treatment of split gums and which only take partially on the radicular surface.

Gingiva↗