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Biomedical subjects

G Gahl

Publications and source records attributed to G Gahl.

8 recordsLinked to original sources
PubMed1979

[Quantitative computerized tomographic bone mineral analysis in patients treated by regular haemodialysis (author's transl)].

Quantitative bone measurement has been done on the forearms of 40 patients (aged 20 to 67 years) undergoing long-term haemodialysis treatment. It turned out that trabecular bone shows a more substantial change of the mineralization than does cortical bone. In comparison to an age-correlated undialysed normal range the mean trabecular bone density was found decreased up to 100 percent, whereas cortical bone with a mean demineralization of 10 percent did not appear to be affected by the renal osteodystrophic alterations to that degree. Finally the results show that throughout the course of dialysis treatment there was a trend toward distinct loss of bone mineral with time. No relationship could be demonstrated between the bone mineral values and various biochemical parameters. The estimation of osseous mineral content in both trabecular and cortical bone was done with the aid of an improved computer assisted tomographic method introduced by Rutherford and Pullan.

Adult↗
PubMed1979

[Radioimmunological determination of HBeAg/anti-HBe in HBsAg-positive liver diseases and in "healthy" HBsAg carriers].

This paper describes a "solid-phase"-radioimmunoassay for the demonstration of HBeAg and anti-HBe. The investigations revealed the following results: 1. HBeAg is positive in all patients with acute type B-hepatitis during the acute phase of illness. During the normal course of the disease HBeAg turns to negative followed by an anti-HBe lasting for several months. 2. Cases with a persistent virus B-replication as HBsAg-positive CPH, CAH or patients on hemodialysis are positive for HBeAg in their serum. By means of the fluorescent antibody technique these patients have demonstrable HBcAg and HBeAg in their liver biopsies. 3. Healthy HBsAg carriers are anti-HBe-positive in their serum. In their liver biopsies there are no signs of an on-going virus B-replication (HBsAg and HBeAg negative). 4. The radioimmunological determination of HBeAg and anti-HBe enables us to differentiate between the groups with HBsAg positive acute or chronic hepatitis and the group of healthy HBsAg-carriers.

Antibodies, Viral↗
PubMed1979

Central and peripheral haemodynamics in longterm peritoneal dialysis patients.

A study was undertaken in 11 longterm peritoneal dialysis (PD) patients to evaluate the acute haemodynamic effects of PD. After filling the abdomen with 1, 2 and 3L of dialysate, intra-abdominal pressure and inferior vena cava pressure increased up to 140 and 98% respectively, whereas central haemodynamic parameters were unchanged. Venous capacity decreased by 18%. Mean weight loss during PD was 1.6kg. The most striking post-PD changes were a significant 19% decrease of cardiac index and 18% decrease of pulmonary artery pressure. Heart rate and arterial pressure remained constant due to a 24% increase in total peripheral resistance.

Adult↗
PubMed1978

[Bone density measurements by computer tomography (author's transl)].

The suitability of the E.M.I. mark I computer scanner for carrying out bone densitometry has been tested, using the forearm. Within the region of interest there was an almost linear relationship between CT densities and the concentration of the bone equivalent substance K2HPO4. By means of a special computer programme, the spongiosa and cortex of both forearm bones could be analysed quantitatively. The reproducibility of the results (coefficient of variation 5%) was similar to that of other procedures in current use. The advantage of the method lies in the fact that it is possible to estimate the spongiosa and cortex separately. Investigations on patients with normal bones have shown that senile demineralisation affects the cortex most severely. On the other hand, in renal osteopathies of chronically dialysed patients, demineralisation in the forearm predominantly involves the spongiosa.

Absorptiometry, Photon↗
PubMed1976

[Bone scintigraphy in renal osteopathy].

25 Patients with chronic renal disease are investigated. In 16 cases with conservative treatment the bone scintigram showed pathological uptake according to the creatinine level, mainly in the joints of iliosacrum, hip, knee and ankles. In three patients increased uptake in the skull was found. The bone uptake found by scintigraphy was highly pronounced in the patients treated by dialysis. The most frequently involved regions were the joints of iliosacrum and hip, facial cranium, skull, pelvis and metatarsus. The count-rate ratio of cranium to chest was significantly increased in 6 patients. The investigations 6 months later showed in 4 cases a further increase compared with the first values. Count-rates of the skull were found to be comparable to the highly increased uptake in Paget's disease. Bone scintigraphy is a suitable method to estimate semiquantitatively the bone turnover in renal disease.

Alkaline Phosphatase↗