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Biomedical subjects

G Galassi

Publications and source records attributed to G Galassi.

At least 55 records · Page 3Linked to original sources
PubMed1979

Familial amyloidosis with cranial neuropathy and corneal lattice dystrophy.

Five siblings of a Danish family with slowly progressive involvement of the trigeminal, facial, glossopharyngeal, accessory, and hypoglossal nerves beginning at the age of 55-65 years were examined. All had asymptomatic corneal lattice dystrophy. Clinical and electrophysiological investigations also showed evidence of slight neurogenic involvement of the limbs. Conduction velocity along sensory nerves was normal but amplitude of sensory potentials was severely reduced suggesting an axonal affection which was confirmed by sural nerve biopsy. The neuropathy was secondary to amyloidosis revealed by skin and sural nerve biopsies.

Aged↗
PubMedDate not supplied

[Atrial fibrillation and hyperthyroidism: results after thyroidectomy].

Hyperthyroidism patients can develop atrial fibrillation (AF) with a frequency range between 10 and 25%. The Authors consider 256 hyperthyroid patients operated in their Department, from 1985 to 2001. Before and after surgery, thyroid examination, routine blood tests and common diagnostic evaluations were performed. The follow-up has been 12 months and during this period a L-Thyroxine (50-200 mg/die) therapy has been arranged. Before surgery 59 patients (23%) showed an AF associated with palpitations (76%), asthenia (66%), tremors (54%) and dyspnea (43%). The onset of AF was less than 1 months in 18% of cases, less than 3 months in 30% and chronic in remaining 52%. The 87% of patients was already pharmacologically treated. All the patients were treated with anticoagulants, with a INR value between 2 and 3. After the surgery, 47% of patients presented a restoration of the sinusal rhythm, while the 53% showed a stronger therapeutic responsiveness to specific antiarrhythmic therapy. Treatment of FA hyperthyroid patients with FA tends to normalize the function of the thyroid gland (euthyroidism). In our experience the restoring of sinusal rhythm usually develops in patients with 50 years of age (45 +/- 5 years), while in older patients AF tends to be resistant to treatment.

Atrial Fibrillation↗
PubMedDate not supplied

[Cystic tumors of the pancreas: a case of cystadenocarcinoma of the pancreatic head].

Cystic tumors of the pancreas are important, although rare, lesions representing nearly 1% of all neoplasms and 10-15% of pancreatic cysts. The Authors compare clinical data of the case observed with those reported in literature. The described case confirms the peculiar characteristics of pancreatic mucinous cystoadenomas: slow growth, not specific symptoms, poor trend to give local or distant metastases, difficult preoperative differential diagnosis and satisfying oncological resection. Taking into account these parameters and the potential malignant evolution of such tumors, the Authors underline the importance of a radical surgical therapy.

Adult↗
PubMedDate not supplied

[Posterior mediastinum neoplasms: a case of schwannoma].

The Authors report the case of a 33-year-old male affected with an asymptomatic schwannoma of the posterior mediastinum, and review the relevant Literature, discussing the difficulties in making the differential diagnosis of the posterior mediastinum lesions, particularly in the pre-clinical phase. Neurogenic tumors represent about 75 percent of all tumors of mediastinum and about one third of all tumors of the mediastinum. They can originate from the peripheral nervous system group, from the sympathetic nervous system group or, in rare cases, from the vagus nerve. In adult patients, they are usually found by chance during radiographic examination of the thorax, and they are usually asymptomatic and benign. During preoperative evaluation, a magnetic resonance examination of rachis should be done to exclude the possibility of intraspinal involvement. If there are no contraindications, the treatment of choice should be surgical resection by means of thoracoscopy or thoracotomy, when size and location of the tumors allow it in order to prevent malignant evolution.

Adult↗
PubMedDate not supplied

[On statistical evaluation of efficacy for dichotomous test result].

Today in our country multivariate statistical analysis in health science are not very widespread, they are used only in few selected health center. So I will try to elucidate some multidimensional procedure to evaluate dichotomous results in diagnostic test. Anyway, someone can take a further advantage to apply these techniques to complex therapeutic treatments. New technologies make possible everyone to process data by means of the multivariate methodology, so I propose tested techniques like logistic regression combined with area under the ROC (Receiver Operating Characteristic) curve.

Diagnostic Techniques and Procedures↗