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Biomedical subjects

G Galle

Publications and source records attributed to G Galle.

4 recordsLinked to original sources

Psychopathometric demonstration and quantification of mental disturbances following myelography with metrizamide and iopamidol.

Groups each consisting of ten patients underwent lumbar and cervical myelography with metrizamide and iopamidol, together with a control group of ten patients who underwent lumbar punctures only. These groups were studied with a psychopathometric test procedure in order to demonstrate and quantify mental disturbances. It was shown that in contrast to myelography with iopamidol, mild mental disturbances are common after myelography with metrizamide. The severity of the mental disturbances after myelography with metrizamide was dependent on the quantity of contrast medium which diffused into the intracranial space after myelography, suggesting a dose-related neurotoxic effect of this substance. Such a correlation was not found with iopamidol.

Adolescent↗

[Malignant cerebellar infarct].

Three patients with cerebellar infarcts and secondary obstructive hydrocephalus (hydrocephalus occlusus) are described, the condition being due to the space-occupying action of the ischaemia and oedema zone with compression and displacement of the fourth ventricle and/or obstruction of the aqueduct. Possible brain stem compression and danger of cerebellar tonsillar herniation were present. From the acute deterioration of the clinical picture, particularly of the state of consciousness, as well as from the findings obtained via computed tomography showing a widening of the inner ventricular space, it was imperative to perform emergency pressure-relieving drainage surgery with ventriculo-atrial shunts in all the cases described. The first two patients could be discharged postoperatively with successful treatment, only slight neurological disturbances remaining. This leads to the conclusion that a (malignant) cerebral infarct should be treated as an emergency case, in a somewhat similar way as in cases of cerebellar haemorrhage or other space-occupying lesions in the posterior fossa of the skull. To recognize the life-threatening exacerbation, sufficient observation and supervision will be necessary. Rapid deterioration in consciousness should be considered a sign of increasing intracranial pressure progressing with the development of hydrocephalus internus occlusus. After neuroradiological diagnosis, especially after verification via computed tomography, this should be interpreted as an indication for immediate neurosurgical intervention. This is the only way to keep the mortality rate satisfactorily low. Dichotomy of cerebellar infarcts into a benign type with spontaneous decrease of symptoms and signs, and a malignant type with development of hydrocephalus internus and increased intracranial pressure, such as in the cases described here, is suggested.

Cerebellum↗

[Importance of the orbital collateral circulation for the origin of ischemic ophthalmopathy in stenotic diseases of the internal carotid artery].

Ischemic ophthalmopathy is the leading ocular symptom of occlusive processes of the internal carotid artery. It can be preceded by embolic symptoms as amaurosis fugax or occlusion of a branch or the main stem of the central retinal artery. Both, ophthalmologists and neurologists, should be familiar with these disturbances as they can involve important diagnostic and therapeutic consequences. Five out of six patients with an angiographically demonstrated extracranial occlusion of one internal carotid artery and a retrograde collateral circulation to the intracranial space via the external carotid and the ophthalmic arteries showed an ischemic ophthalmopathy of the ipsilateral eye. This high coincidence supports the notion that an ischemic ophthalmopathy may not be the result of the occlusive process of the internal carotid artery per se, but may be caused by ocular "steal mechanisms" due to the retrograde orbital collateral circulation.

Adult↗

[Stenoses of the cerebral arteries in pseudoxanthoma elasticum (author's transl)].

The Grönblad-Strandberg-Syndrome (Pseudoxanthoma elasticum) is a systemic disease of the elastic tissue, typical symptoms being lesion of skin and ocular fundi. The frequently appearing vascular changes, particularly of occlusive nature, are important for the patient's prognosis. Several clinical observations had led different authors to assume cerebrovascular involvement. Our neuroradiological findings support this opinion: In this report on a 45-year-old patient with acute hemisyndrome, we demonstrated, for the first time using computerized tomography, ischemic infarcts of both cerebral hemispheres. Cerebral angiography showed bilateral stenoses of the internal carotid arteries with further irregularities of the lumen of the intracranial arteries.

Carotid Artery Diseases↗