Biomedical subjects
Publications and source records attributed to G Galluccio.
Details are presented on the endoscopic treatment of a series of 70 patients with tracheal on bronchial foreign bodies. Diagnosis was made on the basis of a careful examination of anamnestic, clinical, radiological and endoscopic data.
A physiotherapeutic approach, with manual maneuvers and/or distraction appliances, is indicated in the treatment of temporomandibular joint disorders (TMDs) to prevent the progressive fibrosis of the muscle fibers. In this article, the authors report preliminary results of experimental and clinical studies conducted to assess the real effect of distraction in temporomandibular joint disorders. The experimental invivo studies confirmed the structural alteration due to compression and distraction on the capsular and condylar tissues. Clinical cases are reported to show the increase of the intraarticular vertical dimension, with a forward and downward movement of the condyles in a more physiologic condition.
Interferon-alpha (IFN-alpha) is a cytokine exerting pleiotropic activities, including antimicrobial effects, especially directed against intracellular infectious bacteria. It may be administered by aerosol to reach the lower respiratory tract without systemic side effects. The aim of the study reported here was the evaluation of aerosolized IFN-alpha treatment (3 MU/dose, given three times a week; total study dose: 72 MU/2 mo) in combination with conventional antimycobacterial therapy in patients with pulmonary tuberculosis. Two groups of 10 patients each were compared before and after 2 mo of conventional antituberculous chemotherapy with or without inhaled IFN-alpha. Several biologic (bronchoalveolar lavage fluid [BALF] cellularity, Mycobacterium tuberculosis [MT] number in sputum), biochemical (BALF concentrations of 10 cytokines, BALF IFN-alpha receptor levels), and clinical (fever, vital signs, high-resolution computed tomography [HRCT] images) measures were made in these patients at the time of their enrollment and at the end of the observation period of the study. Fever, MT number in sputum, and abnormalities in HRCT images showed significantly earlier resolution in the IFN-alpha-treated group, together with a more significant decrease in BALF interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) concentrations and significantly greater pre- versus posttreatment variations in IL-2 and IFN-gamma. These data, taken together, suggest that IFN-alpha administration may favorably affect the evolution of pulmonary tuberculosis when combined with antimycobacterial therapy.
Chemotherapy is the most effective treatment for inoperable patients (70%) affected with non-small cell lung cancer (NSCLC). The early detection of tumour progression is mandative in order to promptly shift these patients towards salvage or supportive therapy. The present authors investigated the clinical value of a panel of tumour markers, elaborated by means of discriminant analysis, as a follow-up indicator for the detection of tumour progression. The serum levels of tissue polypeptide antigen (TPA), CYFRA-21.1, neuron-specific enolase (NSE) and carcino-embryonic antigen (CEA) were determined before chemotherapy and after three cycles of treatment. Discriminant analysis generated a formula (canonic variable) which correctly classified the 87.8% of the 74 subjects (86.1% of the 36 progressive diseases and 89.5% of 38 non-progressive diseases). This approach produces an algorithm able to calculate a progression score in NSCLC patients which can be helpful for following-up care and therapy control of these patients.
The Authors experimented the use of "modified" straight wire orthodontic appliance on an experimental group of 15 patients who present orthodontic problems with skeletal I, II and III class. Treatment difficulties and results were compared with those obtained in a control treated by the Tweed technique. The Straight Wire appliance proved to be able to reduce, especially in class III problems, treatment's length. Besides, the easiness of learning and performing the orthodontic straight wire technique was evaluated. The Authors found that the main difficult for the Tweed technique is the necessity of a good manual ability, while the most important problem using the straight wire technique is the correct positioning of the brackets.
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Solitary plasmacytic lymphomas are rarely described in the lung. Generally, localized neoplasms develop into mediastinal or pulmonary lymphnodes and are hard to differentiate from other lung neoplasms. An involvement of the chest wall in multiple myeloma is not rare, and is generally associated with other skeletal localizations. A secreting solitary plasmacytoma of the ribs is rather uncommon: a personal review of the literature has showed, in the last ten years, only two cases of these tumors, secreting IgG lambda light chains. In this study we report a case of solitary plasmacytoma of the chest wall, associated with an IgG kappa monoclonal gammapathy.