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Biomedical subjects

G Garrone

Publications and source records attributed to G Garrone.

35 records · Page 2Linked to original sources
PubMed1983

Elimination and pharmacological effects following single oral doses of 50 and 75 mg of amitriptyline in man.

In a companion paper we described the disposition of a 75 mg single dose of amitriptyline in normal volunteers who were phenotyped as extensive or poor metabolizers of debrisoquine and bufuralol, and had a four-fold range in the oral clearance of the antidepressant, 50 mg of amitriptyline was also administered to the same volunteers. This paper compares the results after both doses and suggests that the disposition of amitriptyline is linear even in subjects with a low oral clearance. There was no relation between the pharmacokinetic data and the intensity of sedation or of psychomotor impairment.

Administration, Oral↗
PubMed1982

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man.

We have measured the metabolites (demethylated and hydroxylated) of amitriptyline in a group of seven normal volunteers. They were phenotyped as extensive or poor metabolizers using debrisoquine and bufuralol. The results demonstrate that the oxidative metabolism (aliphatic hydroxylation) of amitriptyline is under the same genetic control as that of debrisoquine and bufuralol. However, phenotypic polymorphism cannot be used to predict amitriptyline blood concentration after a single oral dose, since the principal metabolic pathway of amitriptyline is demethylation and not aliphatic hydroxylation.

Adult↗
PubMed1981

[Psychotherapies: current status and perspectives].

A multitude of psychotherapic methods are proposed to the patients and their demand for psychotherapy is steadily increasing. The reasons of this phenomena are analyzed by the authors. On the basis of their different conceptual background and their ends, the psychotherapies are divided in six groups. The criteria by which the choice of a method is made as well as this of different possible associations are discussed. The assessment of efficacy is considered. The social implications and future of the different psychotherapic methods are screened.

Behavior Therapy↗
PubMed1975

[Psychiatry today and psychiatry tomorrow].

In the light of present knowledge the author examines the courses which psychiatry of the future could follow. In the fields concerning secondary or tertiary prevention it seems probable that psychiatry of the future is situated in a line of continuity in relation to psychiatry of the present, while affirming and complementing it. On the other hand, primary prevention still requires to be found, the operational models of the past and present being manifestly inadequate.

Forecasting↗