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G Gaspar

Publications and source records attributed to G Gaspar.

17 recordsLinked to original sources
PubMed1992

[Follow-up of the patient with HIV infection: a hospital task?].

OBJECTIVE: To assess how often patients with HIV infection abandon treatment. DESIGN: Longitudinal, prospective and observational study. SITE. Out-patient Hospital Clinic. PATIENTS AND OTHERS PARTICIPANTS: The total number of patients with HIV infection treated between September 1989 and December 1990. INTERVENTIONS: Assessment of the level of out-patient follow-up. MEASUREMENTS AND MAIN RESULTS: The rate of abandonment of out-patient follow-up was determined, with "abandonment" defined as unexplained non-attendance for at least two consecutive appointments. Its possible correlations with sex, age and HIV risk behaviour was calculated. 182 patients (143 men and 39 women) with an average age of 30.1 (ds 8.62) were surveyed. The abandonment rate for the sample as a whole was 44%, with no difference as to sex. However the abandonment rate was higher in the group of patients addicted to drugs (DDA) (69%) than in non-DDA (25%) or in ex-DDA patients (6.5%). These figures reached high statistical significance (p less than 0.01 and 0.001 respectively. CONCLUSIONS: The abandonment rate of out-patient hospital follow-up by HIV-infected patients appears extremely high, especially among drug addicts (DDA).

Acquired Immunodeficiency Syndrome↗
PubMed1992

[Spontaneous pneumothorax and Pneumocystis carinii pneumonia. Something more than a casual association?].

The association of spontaneous pneumothorax and Pneumocystis pneumonia is not frequent. The medical literature reports a ratio between 0 and 5.7%. In 18 patients admitted in our hospital, in the last two years, and diagnosed of AIDS and Pneumocystis pneumonia, we observed two cases of pneumothorax spontaneous. They represent the 11%. In one of them spontaneous pneumothorax was the first manifestation and in the other a complication of the illness. It was not possible to isolate an agent different from Pneumocystis carinii. Considering the lack of predisposition factors and the previous clinical history, we think that Pneumocystis carinii is by itself the agent responsible of this complication. In view of this possibility, spontaneous pneumothorax in a patient who belongs to an AIDS' risk group will alert the clinician to the possibility of infection with Pneumocystis carinii.

Acquired Immunodeficiency Syndrome↗
PubMed1977

Incorporation and metabolism of stearic, oleic, linoleic and alpha-linolenic acids in minimal deviation hepatoma 7288 C cells.

Minimal Deviation Hepatoma 7288 C cells were cultured in confluent layer with labeled stearic, oleic, linoleic and alpha-linolenic acids. The kinetics of incorporation and conversion to higher homologs was studied. The maximum amounts incorporated in nmoles per mg of cellular protein for stearic, oleic, linoleic and alpha-linolenic acids were 39, 115.6, 90 and 230 respectively. alpha-linolenic acid was converted to octadeca-6,9,12,15-tetraenoic acid (18:1), eicosa-11,14,17-trienoic acid (20:3), eicosa-8,11,14,17 and 5,11,14,17-tetraenoic acids (20:4) and eicosa-5,8,11,14,17-pentaenoic acid (20:5), and also to myristic, palmitic, palmitoleic, stearic and oleic acids. By a mathematical approach, the endogenous pool size of alpha-linolenic acid available for conversion to eicosa-5,8,11,14,17-pentaenoic acid, were calculated. Both values decreased when the cells were preincubated with unlabeled alpha-linolenic acid.

Carcinoma, Hepatocellular↗
PubMed1975

Uptake and metabolism of exogenous eicosa-8,11,14-trienoic acid in minimal deviation hepatoma 7288 C cells.

Minimal deviation hepatoma 7288 C cells were cultured in Swim's medium containing 10% serum for 48 hr. The growth medium was replaced with serum free media containing different concentrations of [1-14C] eicosa-8,11,14-trienoic acid and the cells were incubated for 24 hr. Incorporation into cell lipids, oxidation to CO2, and desaturation to arachidonic acid were studied. The oxidation of the acid was very low. It was preferentially incorporated into the polar lipids of the cell. The incorporation depended on the number of cells and fatty acid concentration. Saturation of the cells with the acid was reached when 144.7 nmoles per mg of cellular protein were incorporated. The acid was desaturated readily to arachidonic acid. The nmoles of eicosatrienoic acid converted to arachidonic acid per mg of cellular protein were hyperbolic function of the acid incorporated. Maximal desaturation, 23 nmoles per mg of cellular protein, was reached when the cells were saturated with the acid. The calculations of the desaturation capacity and of the endogenous pool of eicosatrienoic acid available for desaturation in the cell are discussed.

8,11,14-Eicosatrienoic Acid↗
PubMed1975

[Effect of an essential fatty acids free diet on the lipidic composition of rat testicles (author's transl)].

The effect of a fat free diet on the fatty acid composition and histological changes of the testis of old rats was studied to investigate the possible function of docosa-4,7,10,13,16-pentaenoic acid in rat testicles. The lipidic composition, the fatty acid composition, the conversion of docosa-7,10,13,16-tetraenoic acid to arachidonic acid and the activity of the 6-desaturase were determined during the different periods in which the rats received a fat free diet. Comparatively, the changes in the fatty acid composition of the liver were also studied. Only the liver showed a change in the triglyceride content during the first month of treatment, and it regained its normal values afterwards. Both liver and testis changed the fatty acid composition. An increase of the acids of the oleic series and a decrease of the components of the linoleic series were shown. These changes were similar to the ones provoked by an essential fatty acid deficient diet on young animals. The amount of docosa-4,7,10,13,16-pentaenoic acid was very little changed. No significant change was shown either in the retroconversion of docosa-7,10,13,16-tetraenoic acid to arachidonic acid. However, the 6-desaturase activity of the testis was enhanced by the fat deficient diet. The possibility that arachidonic acid in the adult rat is mainly supplied by linoleic acid and not by the retroconversion of docosa-4,7,10,13,16-pentaenoic acid is discussed.

Animals↗