Biomedical subjects

G Gaston

Publications and source records attributed to G Gaston.

5 recordsLinked to original sources

PubMed1996

A double-blind, randomized, parallel-group study of the pharmacokinetics and onset of action of Naprelan in patients following oral surgery.

Naprelan (Wyeth-Ayerst Laboratories, Philadelphia, Pennsylvania) is a novel formulation of naproxen sodium designed to offer both a rapid onset and a sustained duration of analgesia. Its onset of action was assessed in a double-blind, double-dummy, randomized, parallel-group study of 129 patients who had just undergone oral surgery to remove impacted third molars. Patients received Naprelan (500 mg or 1,000 mg), naproxen (500 mg), codeine (30 mg), or placebo. Both doses of Naprelan compared favorably with the established Naprosyn (formulation of naproxen; Syntex Laboratories, Inc., Palo Alto, California) with respect to onset of action, which occurred within 30 minutes in the majority of patients. The relative adverse effect profile showed that both Naprelan doses were as well tolerated as Naprosyn, codeine, and placebo. Pharmacokinetic and pharmacodynamic analysis confirmed the findings of previous Phase I studies in healthy subjects.

Adolescent↗

PubMed1993

Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery.

The purpose of this study was to compare the analgesic efficacy and safety of meclofenamate sodium with ibuprofen after dental impaction surgery. This study was double-blind and used a unique methodology. Patients (N = 254) were first randomized into the single dose phase of the study that included placebo, meclofenamate 50 mg, meclofenamate 100 mg, ibuprofen 200 mg, and ibuprofen 400 mg, followed by a 7-day multidose phase in which patients in the placebo group were rerandomized into one of the active treatment cells. In the single dose phase, all active treatments were significantly more efficacious than placebo for every summary analgesic measure. A positive dose-response was seen for both active drugs with meclofenamate 100 mg and ibuprofen 400 mg exhibiting the greatest efficacy for pain relief, pain reduction, time to remedication, and overall evaluation. Side effects were reported by 26 patients. They were evenly distributed among treatment groups with headache and drowsiness being the most common. During the multidose phase, there were only small differences in efficacy measures among active treatment groups. However, meclofenamate produced a higher incidence of stomach cramps and diarrhea than did ibuprofen (8.8% and 7.2% versus 0.8% and 0.8%). This study indicates that higher doses of nonsteroidal anti-inflammatory drugs are most effective immediately after surgery and that lower doses of these drugs can be used after the first postoperative day. The side effect profile of nonsteroidal anti-inflammatory analgesics is best observed with the use of a multidose study design.

Abdominal Pain↗

PubMed1980

Multiple hamartoma and neoplasia syndrome (Cowden's syndrome).

A case report involving a patient with Cowden's syndrome is presented. The patient's family is shown to be affected in a pattern consistent with an autosomal dominant form of transmission of this inherited disorder. The disorder can be diagnosed in its early stages by gingival and cutaneous manifestations; it is emphasized that the dentist is therefore perhaps the best-qualified health care professional to recognize the disease in its early stages and to alert the patient to be monitored for later predictable neoplasia which can perhaps be treated before metastasis develops.

Adult↗

PubMed1979

Amelogenesis imperfecta: local hypoplastic type with pulpal calcification.

A case report of a patient with local hypoplastic type of amelogenesis imperfecta is presented. Developmentally absent canines and unerupted teeth in the anterior maxilla and calcifications in the apical third of the pulp chambers of the molars were noticed and discussed. A family history was analyzed as consistent with an autosomal dominant form of transmission of the disorder.

Adult↗

PubMedDate not supplied

[Remarks on the ecological adaptation of the snail aquatic fauna in saline medium of the Dallol ponds. (Republique du Niger) (author's transl)].

Human vesical and intestinal bilharziasis, bovine fasciolosis and paramphistomosis, equine gastrodiscosis and ovine carmyeriosis, are frequent in the Dallols'region, (12 degrees - 13 degrees 30 N. lat. ; 3 degrees E. long.), Republique du Niger, Africa. Dallols are fossil valleys pouring water from late Saharian lakes. They are also tributaries of the Niger River. During the dry season, they become dry and many residual ponds of varied dimensions; from tens feet to one or two miles long, are lying along the valley bottom. The water is sometimes fresh but more frequently salt, (sodium, calcium and potassium, chlorides, sulfates, carbonates and bicarbonate), are in solution of variable proportions. From november to april, the total salt concentration is increasing by high evaporation and the medium becomes non likely to live for aquatic vector snails, Bulinus truncatus, Biomphalaria pfeifferi, Bulinus forskalii, Lymnaea natalensis and Afrogyrus coretus.

Adaptation, Physiological↗