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Biomedical subjects

G Gebert

Publications and source records attributed to G Gebert.

At least 19 recordsLinked to original sources
PubMed1983

[Transmucosal potential difference of the stomach wall in man and its relation to HCl secretion].

The measurement of the gastric transmucosal potential difference (PD) in healthy volunteers under endoscopic control revealed: 1. The local PD can be observed also in regions where oxyntic cells are rare or absent. 2. When the gastric mucosa ist irritated mechanically by the tip of the electrolyte bridge, the local PD is declining and becomes poorly reproducible. 3. The reduction of the PD by pentagastrin can be observed even after blockade of the HCl-secretion by cimetidine. It has two components, a rapid and a slower one. Our results are questioning the concept of an electrogenic HCl-transport as the source of the PD and the interpretation of the PD as a quantitative indicator for the functional integrity of the mucosa barrier.

Adolescent↗
PubMed1975

Cyclic AMP and the potassium-induced vasodilation.

The cAMP concentration of bovine facial arteries (helical strips) increased from 0.84 +/- 0.14 to 1.51 +/- 0.24 nmole/g wet weight, when the strips were relaxed by exposure to a physiological salt solution containing 10 instead of 2.7 mM KCl. A similar result (increase from 1.13 +/- 0.15 to 2.07 +/- 0.29 nmole cAMP/g wet weight) was obtained in strips pretreated with 10(-7) g/ml beta-methyldigoxin. These strips reacted to 10 mM KCl with a constriction. Addition of the phosphodiesterase activator N-methyl-imidazole (3 - 10(-3)M) did not affect the mechanical response to 10 mM KCl. It is concluded that for the potassium-induced vasodilation cAMP does not have a mediating function comparable to that in beta-adrenergic relaxation of vascular smooth muscle.

Animals↗