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Biomedical subjects

G Gefferth

Publications and source records attributed to G Gefferth.

10 recordsLinked to original sources
PubMed1987

Growth hormone reserve in diabetes mellitus.

The magnitude of hGH reserve was investigated in young (16-40 years old) diabetic patients. Forty patients were examined with the arginine infusion test, twenty three with a sensitized version of the L-Dopa test. The patients were divided into four groups based on the type of their illness (IDDM or NIDDY) and the clinical stage of IDDM. It was concluded that the hGH reserve of the various diabetic groups differs from the hGH reserve of healthy persons as well as from one another. Taking into consideration the possible causes of these differences, it is suggested that the hGH reserve depends primarily on the metabolic condition of the patients, while the type of diabetes (IDDM or NIDDY) and the insulin therapy used may also be important contributing factors. Achievement of a good metabolic control within the same type of diabetes leads to the normalization of the previously pathologic hGH reserve.

Adolescent↗
PubMed1978

[Effect of various edible oils on the monoxygenases in liver of rats].

2 months old male rats were fed over a period of 10, 30 and 60 days a diet containing 1.20% sunflower oil, 2.10% sunflower oil and 10% rapeseed oil, 3.6% sunflower oil, 8% rapeseed iuk abd 6% soybean oil. The diets caused changes in the composition of the fatty acid of total lipids and in the activity of the monoxygenase in the liver. The level of the oleic acid in the livers of the 2nd and 3rd groups was elevated. The linolic acid level was elevated in all three groups, the level of the 1st group being the highest. The arachidonic acid level was diminished in all three groups. The aminopyrine demethylase activity increased in all groups only on the 60th day, the activity of the 1st group being the highest. The aniline hydroxylase activity of the 2nd group had a transient increase on the 30th day; on the 60th day only the activity of the 1st group was elevated.

Aminopyrine N-Demethylase↗
PubMed1978

Metabolic effects of clofibrate on experimental animals.

The effect of ethyl-alpha-(p-chlorophenoxy)-isobutyrate (clofibrate, Miscleron) on certain parameters of lipid and carbohydrate metabolism was studied in male and female white rats. The vitamin A content and the mixed function oxydase activity in the liver was also examined. 1. In short-term experiments over 10 to 30 days clofibrate significantly influenced the examined parameters. In a long-term experiment (9 months), however, these changes were no more observable. 2. Clofibrate exerted a protective effect against lipid mobilization following physical exercise (swimming). 3. No significant differences between male and female rats after clofibrate treatment could be observed.

Animals↗
PubMedDate not supplied

Arginine induced growth hormone (hGH) response and paradoxical hGH secretion stimulated by TRH in diabetes mellitus.

Growth hormone (hGH) reserve following arginine administration and the paradoxical hGH response to thyrotropin-releasing hormone (TRH) were studied in 30 diabetics without evidence of vascular complications. The diabetics were divided into 4 groups according to the type of their disease and to the metabolic condition within the IDDM group (insulin-dependent: IDDM, in acceptable response and in poor metabolic control; non-insulin-dependent: NIDDM, and juvenile diabetics not requiring insulin at least for two years after diagnosing their disease: NIDDY). The results were compared with controls of identical age and normal weight. A paradoxical hGH response to TRH stimulation was found only in IDDM patients in poor metabolic control. In this group the hGH reserve revealed by arginine was significantly larger than in the others. It was shown that the induced hGH release was independent of the sex distribution of the groups and of the basal hGH values. Magnitude of the hGH reserve and appearance of the paradoxical hGH response were not necessarily correlated but the substantial reserve was frequently associated with a paradoxical response. It can be assumed that the unfavorable metabolic condition is of decisive importance in giving rise to these anomalies. Our observations seem to confirm the need for good metabolic control if the pathological hGH secretion in diabetics is to be prevented.

Adult↗