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G Geiler

Publications and source records attributed to G Geiler.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Immunohistochemical studies of the synovial membrane in rheumatoid arthritis and osteoarthrosis for quantifying lysozyme and alpha-1-antitrypsin positive mononuclear cells].

The exact number of lysozyme- and alpha-1-antitrypsin-positive macrophages in the synovial membrane in rheumatoid arthritis and osteoarthrosis was investigated by the PAP-technique. There is a positive correlation between the number of macrophages in the intima, as well as in the adventitia of the synovial membrane, and the local immunological activity of rheumatoid arthritis. However, there exist significantly less positive macrophages in osteoarthrosis. The significant increase of macrophages in cases of rheumatoid arthritis is an expression of immunopathological mechanisms that have a pathogenetic importance for the induction and recidivity of arthritis. These facts justify therapy with antirheumatica to influence macrophages.

Adolescent↗
PubMedDate not supplied

[Vasculitis with anemia infarcts of the villi of the synovial membrane in rheumatoid arthritis].

The observation of partial or total necrotic synovial villi in cases of rheumatoid arthritis was the occasion to examine if these necroses are caused by an obturated vasculitis and can be interpreted therefore as anemic infarcts. We have investigated 415 synovial membranes of 200 patients with rheumatoid arthritis. 5% of the synovial membranes in 10% of the patients showed infarcts of villi with necrotizing thrombovasculitis of the main artery or several vessels at the basis of villi. The infarcts were frequently localized at the hand (12.5%) and elbow (10.5%) joints. The infarcts of villi have a relation to the local histologic activity of the synovialitis. Only synovial membranes with high and middle activity show corresponding findings. There was no syntropy with rheumatoid granulomas. Because necroses of villi without vasculitis are also seen, it remains to be answered if these are caused by a provable vasculitis, or by another pathogenesis. The fate of the infarcts is different--some enter the joints as "rice bodies", others organize from a basis of villi. The infarcts of villi are expressions of a severe local disturbance of circulation. They are able to potentiate the local activity and the progress of synovialitis.

Adult↗
PubMedDate not supplied

[Methods and value of an immunofluorescence-optical determination of IgM, IgG and IgA rheumatoid factors].

Today the immuno-fluorescence technique is the simplest method to detect rheumatoid factors of all immuno-globulin classes. When applying sheep erythrocytes, standard sera may be used without exception. The airdried smear of the cells is to be incubated with rabbit anti-human-erythrocyte serum. The rheumatoid factors of the subsequently applied inactivated patients' sera localise above the amboceptor on the erythrocyte membrane. Only they bind FITC marked anti-human-gamma-globulin and cause a specific fluorescence. As a proof heteroagglutinines and crossreacting antibodies of the marked sera are first absorbed and corresponding controls are carried out. According to assessments of 101 sera approximately 20% of healthy people, approximately 50% of "definitely seronegative" patients with rheumatoid arthritis according to the agglutination method as well as 30% of other arthropathies had rheumatoid factors by these methods. A negative immunofluorescence optical test does not absolutely exclude the presence of rheumatoid factors in the serum. It is suggested that their occurrence are due to secondary reactions to the formation of immunogen antigen-antibody complexes.

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

[The effect of D-penicillamine on experimental allergic arthritis in rabbits].

The effect of D-penicillamine on experimental allergic arthritis in rabbits (16 with arthritis and 15 controls) was investigated. After 40 days of treatment with D-penicillamine (intravenous) the arthritis had receded to a large extent. At the same time a maturation inhibition of the hematopoietic marrow had occurred in all the treated arthritic and control animals. The results suggest that D-penicillamine affects fast proliferating cells, to which the precursors of immunologically active cells in the synovial membrane also belong.

Animals↗
PubMedDate not supplied

[Changes in the synovial membrane in early diagnosed cases of rheumatoid arthritis. II. Immunohistochemical and serological studies].

To extend the histologic-histochemical examinations on so-called early cases of rheumatoid arthritis (RA, Geiler and Emmrich 1980) additional immuno-histochemical and serological tests were carried out on the same subjects. The purpose was to find out to what extent the well-known humoral immunological abnormalities of RA cases with fully developed disease (so-called late cases) occur in the early stage of RA. It was also aimed to determine their diagnostic and pathogenetic significance. The synovial membranes were tested immuno-histochemically for rheumatoid factor, immunoglobulins, and complement fixation for the complement factors C3, C4 and C9. In the serum the rheumatoid factor was assayed by the latex test and its immuno-globulin class specificity by means of an immunofluorescence test. In contrast to observations in the late cases, rheumatoid factors, immuno-globulins and complement deposits are found less often. In the class specificity test of rheumatoid factor in the serum there are considerably more positive cases than with the latex test. In the synovial membrane and in the serum there are positive cases also in juvenile RA-cases. For the diagnosis of early cases the immuno-histochemical demonstration of the rheumatoid factor in the synovial membrane is of great importance. The diagnosis RA may thereby the secured. --In the pathogenesis the accumulation of vasculitides with deposits of immune-complexes may be important. Possibly a vasculitis induced by immune-complexes represents the initial reaction of the rheumatoid synovitis. Since in the early cases little synthesis and deposits of immuno-globulins, rheumatoid factors and complements are found, it may be assumed that the more active humoral immunological activity of the synovial membrane of the late cases develops slowly during the course of the disease.

Arthritis, Rheumatoid↗