PubMed Health⌕ Search

Biomedical subjects

G Genchev

Publications and source records attributed to G Genchev.

13 recordsLinked to original sources
PubMed2003

[Comparative diagnostic characteristics of carbohydrate metabolism disorders in women with polycystic ovary syndrome (PCOS)].

The aim of the study was to compare the information provided by both fasting and stimulated during a standard oral glucose tolerance test (oGTT) levels of glucose and insulin as regards glucose tolerance and insulin resistance in women with PCOS. Few criteria are used in practice to verify insulin resistance in PCOS--elevated fasting insulin, decreased basal glucose/insulin ratio (< 6 for glucose in mg/dl or < 0.333 for glucose in mmol/l), insulin increase of more than 100 lul during an oGTT, and HOMA index > 2. The study comprised of 94 women (mean age 21.8 +/- 5 = 8 ys, mean BMI-30.38 +/- 7 = 7 kg/m2), divided in 4 groups according to BMI--group with BMI < 25, n = 21; group with BMI25-30, n = 27; group with BMI = 30-35, n = 23 and group with BMI > 35, n = 23. An oGTT with parallel determination of blood glucose and insulin was performed in all patients. The ratio basal glucose/insulin and HOMA index were calculated. Glucose levels on the 2 md hour during the oGTT pointed at IGT (impaired glucose tolerance) and/or diabetes in 8.5% of the investigated patients while the fasting levels indicated disturbances in only 2.2% of them. Fasting insulin levels were in the normal range in a considerable part of PCOSE women, mainly those with normal weight, and were not predictive for the response of insulin to glucose load. Relative percent of patients with elevated fasting insulin rose with the increasing of BMI. Decreased glucose/insulin ratio, elevated HOMA index, and abnormal stimulation of insulin were seen in more than 2/3 of the PCOS women including nonobese ones. Information provided by the above three markers was similar and they could be used alternatively according to the particular case and assessment of the cost/benefit ratio.

Adolescent↗
PubMed1998

[Secondary sclerosing cholangitis after echinococcectomy].

This is case report concerning secondary caustic sclerosing cholangitis following scolecide with concentrated sodium chloride solution (30%) during operation on a liver echinococcus cyst with involvement of the extrahepatic biliary apparatus only. Hepatojejunostomy is performed. Histological study of the liver demonstrates evidence of severe cholangitis, purulent cholangiolitis and suspected secondary biliary cirrhosis. In conclusion, it is stressed that dynamic postoperative follow-up of patients is mandatory to make early diagnosis of the complication and undertake operative treatment anticipating the development of a cirrhotic process. The search for new, effective scolicides, not damaging the biliary apparatus and hepatic parenchyma, is strongly recommended.

Acute Disease↗
PubMed1993

[The surgery of huge retroperitoneal tumors].

Observations of successfully operated huge retroperitoneal tumors, one of them weighing 14.700 kg, are reported. The advantages for precise diagnosis of modern visualizing techniques--echography and computer tomography--and the inability to establish always an exact cytologic diagnosis by puncture aspiration biopsy are demonstrated. Total extirpation of the tumor with subsequent combined chemo-, radio- and immunotherapy is advised.

Adult↗
PubMed1993

[A case of epidermoid cysts in the spleen].

A rare case of epidermoid cysts of the spleen in a 16-year-old boy, presenting with early clinical symptoms, is reported. In view of the extreme rarity of primary cysts of the spleen, the authors contemplate on the possibilities for establishing the diagnosis.

Adolescent↗
PubMed1989

[The structure and function of an automated system for predicting neonatal body weight (the Sinodeta P/1)].

The structure and function of an automated nosometric system, created by the authors, for prognosis of the risk of delivery of a child with low weight is described. The system is designed for health services, which give direction to parturient (public health sectors) and obstetric wards without technique and specialists for management of such children. The summarized extract is made on 883 cases, but verification--on 463 cases. The total effectiveness of the system is 82.1% against 66.25% of exact results during intuitive prognosis.

Algorithms↗
PubMed1976

[Epizootiological and parasitological status of the flocks at a poultry combine].

A comprehensive epizootiologic study has been carried out at one of the large poultry dressing combines in this country. Results have shown that the part played by infections as against the remaining diseases established in the various technologic categories is as follows: 9 to 23.8 per cent in growing parents; 16.0 to 24.6 per cent in adult parents; and 4.8 to 13.4 per cent in broilers. So far as parasitic diseases are concerned the respective figures are 3.2 to 9.9 per cent, 3.0 to 3.3. per cent, and 2.9 to 3.0 to per cent. The import of birds from France and England intended for satisfying the needs of the poultry dressing combine in Roussé has contributed to the introduction of infections which have later on assumed an epizootic course, such as infections encephalomyelitis, infectious bronchitis, and Marek' disease. The epizootic status has been aggravated with the development of a number of diseases already existing in this country--fowl pox, lymphoid leukosis, chronic respiratory disease, salmonellosis, and above all infections caused by the so-called occasionally pathogenic agents--coli organisms, staphylococci, and Pseudomonas. Of the parasitic diseases only coccidiosis has developed, being caused by a variety of species: Eimeria acervulina, Eimeria necatrix, Eimeria maxima, Eimeria muvati and Eimeria tenella. The absence of helminth infections is due to the routinely adopted technological practice of raising birds in confinement and the strict veterinary control and guard. On the basis of the results obtained and the conclusions drawn some more effective prophylactic measures are suggested correcting and supplementing the existing prophylactic programme.

Animals↗
PubMed1975

[Passive immunity in calves born of cows that have recovered from foot-and-mouth disease or been vaccinated against it].

It has been found that the antibody titers in the case of passive immunity in calves from cows that have recovered from foot-and-mouth disease or have been vaccinated against it rise immediately following the intake of colostrum. They have been found to reach a peak level, displaying maximal values for a long period of time. Later on the antibody titers decline gradually. Specific antibodies have also been demonstrated at the age of more than two months following birth. Higher values of passive immunity have been established in calves from survivals and from cows that have been vaccinated twice and this is explained by the presence of a higher content of foot-and-mouth disease antibodies in the dams. The importance of passive immunity for the prevention of the disease in growing animals is discussed.

Animals↗