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Biomedical subjects

G Georgescu

Publications and source records attributed to G Georgescu.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Insulinemia and its evolution over time in obesity].

There is a steady-state metabolism of adipose tissue ("adipose state") with a "metabolic signal" significance. It consists of: seric levels of glucose, insulin, free fatty acids. We studied 45 cases with uncomplicated obesity and we correlated seric level of insulin, basal and reactive, with DAM (mean adipocyte diameter), insulin receptor activity and obesity evolution length (age of obesity). Level of insulin has high influence on insulin receptor function (p < 0.01). Reactive insulin level are higher with obesity age (p < 0.0001). Hyperinsulinemia is a constant, continuous and early reference point of obesity.

Adipose Tissue↗
PubMedDate not supplied

[Weibull regression in the analysis of the aging phenomenon of biological systems].

The processing battery represented by standard regressions is totally insufficient for the primary regression analysis of biomedical observation data. Using only this processing system, it is possible to loose a significant amount of information and especially to obtain false conclusions, seeming to be "statistical justified". This conclusion is sustained by the results obtained in this paper on 8 samples. In this paper it was created a calculation algorithm that allows the automatic, simultaneous effectuation of 16 types of regression, obtained by change of variable. This algorithm finally orders these regressions according to the values of correlation coefficient and emphasizes the regression type that mathematically fits the best the observed data. The choice of the optimal regression type depends basically by the fact that the results supplied by that regression corresponds with the biological characteristics of the studied phenomena. In the specific case of optical nerve, in all the 8 samples and sub-samples analyzed, the regression that supplied the higher correlation coefficients was the Weibull model, with exponent variable as a function of time.

Aging↗
PubMedDate not supplied

[Bilateral pulmonary resections for bilateral bronchiectasis].

The present paper reports on 6 cases of bilateral bronchiectasis in patients aged 11 to 63 years, treated by simultaneous bilateral pulmonary resection and 1 case of bilateral bronchiectasis in which 14 segments were resected successively. Surgery by simultaneous bilateral approach and associated resection of the affected areas is a procedure that should be indicated, in the authors' opinion, only in carefully selected cases in which not more than 13 segments have to be resected. The indications and contraindications of surgery in bilateral bronchiectasis are discussed, preference being given to the simultaneous approach. In the cases reported at most 11 1/2 segments of the four pulmonary lobes affected were resected in a single stage; in 1 case 14 segments were resected successively, the resection exceeding in amplitude all similar one published until now. The immediate and late postoperative evolution (lesional and functional) were favourable, which pleads for a reconsideration of the approach to bilateral bronchiectasis and the application of the surgical treatment recommended, within the limits described.

Adolescent↗
PubMedDate not supplied

[Arrhythmic cardiomyopathy. Case report].

An 11 year-old boy was admitted with incessant sinus node reentrant tachycardia and secondary dilated arrhythmic cardiomyopathy, treated by radiofrequency ablation. Two years later he was admitted with incessant automatic atrial tachycardia and arrhythmic cardiomyopathy; a second catheter ablation procedure failed, but the third one, performed four month later, was successfully and resulted in a restoration of a normal sinus rhythm and a complete regression of arrhythmic cardiomyopathy.

Arrhythmias, Cardiac↗
PubMedDate not supplied

[The etiological spectrum of pure and isolated chronic mitral insufficiency].

The 78 patients with mitral insufficiency studied in the present paper were chosen taking into consideration the following: regurgitant apex holosystolic or mesotelesystolic murmur, noise 3 and the dilation of the left atrium and/or left ventricle at Echo-20. The patients were investigated clinically, ECG, phonocardiographically and echographically (2D). The etiology was established in 75 patients; non rheumatic causes were present in 70% of the cases. The echographic study, besides the other methods, is very important in diagnosing the mitral insufficiency, in etiology, severity and the degree of deterioration of the pump function of the left ventricle. The Eco-2D examination, a noninvasive method, allows reaching therapeutic medical and surgical decisions at the best moment and helps in assessing the results.

Adult↗
PubMedDate not supplied

[Bronchopulmonary carcinosarcomas. Therapeutic indications].

The authors make an analysis of 11 cases of carcinosarcoma that have underwent surgery in the Clinic of Thoracic Surgery. The authors stress the rarity of these cases in their statistics. Only 11 carcinosarcomas have been identified out of a total of 2.500 cases of bronchopulmonary tumors operated in the Clinic. The difficulty of pre-operatory diagnosis is also stressed. Indications for surgical treatment are mandatory in all cases, even when the expected effects are palliative.

Adult↗