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Biomedical subjects

G Germann

Publications and source records attributed to G Germann.

10 recordsLinked to original sources
PubMed1992

[The epaulette flap: replantation of osteomyocutaneous forearm segments in interscapulo-thoracic amputation].

Despite sophisticated artificial limb devices available today, forequarter amputation following trauma or tumor resection will lead to severe impairment of function. To close the posttraumatic or oncologically required extended defects and to improve prosthetic supplementation coverage of the thoracic wall should be performed by sparing the whole forearm as an osteomyocutaneous flap. In cases of concomitant serial rib resection radius and ulna will serve as stabilizators of the thoracic wall, thus avoiding a flail chest. Indications, technical details and clinical outcome of three salvage replantations after interscapulo-thoracic ablation will be discussed.

Amputation, Surgical↗
PubMed1992

[Differential, oncologically adequate therapy of basalioma].

Surgical treatment of basal cell carcinoma demands straightforward tumor management. This study investigated the radicality of surgical excision, procedures performed for defect coverage, the recurrency rate depending on the histological tumor type, among other parameters. Despite a low general incidence of 14%, sclerodermiformal BCC (morphea-like lesions) is found in 88% of all recurrencies. Based upon the results of this study, the following therapeutic guidelines are recommended: Resection with tumor-free margins must be insisted on, particularly in any exposed surfaces of the body. Histological subtyping by the pathologist is required. After initially incomplete resection in certain histological subtypes, subsequent radical resection is not mandatory. Complete resection of sclerodermiformal BCC is mandatory, and continuous follow-up of these cases is recommended.

Adult↗
PubMed1989

[The effect of arteriovenous fistulas on the metabolism and morphology of striated muscles].

The revascularization of ischemic extremities by retrograde arterial perfusion has been reported in clinical and experimental studies. The effect of retrograde perfusion on hemodynamics and metabolism of skeletal muscle was investigated in 86 rabbits with various types of AV-fistulas. Since blood flow was markedly reduced, levels of energy phosphates (ATP, CP) stabilized on a lower level. In all groups, lactate raised significantly. Focal morphological lesions were seen in all groups in a various degree. A high incidence of thrombosis was found at dissection. Maintenance of blood flow and metabolism after retrograde perfusion seems to be possible on a low level.

Adenosine Triphosphate↗
PubMed1987

[Experimental studies of the effect of an arteriovenous fistula on postischemic skeletal muscle].

Arteriovenous fistulas have clinically been used for revascularization of ischemically damaged extremities. Therefore in an experimental study on hind legs of rats, the histomorphological changes on the M. tibialis anterior and the M. soleus following arteriovenous shunts in the femoral level with and without an ischemic lesion were performed. The results show that it is unlikely, to expect postischemic muscle protection by iatrogenic arteriovenous shunting.

Animals↗
PubMed1986

The role of adrenal medulla in endogenous dopaminergic inhibition of aldosterone secretion.

Evidence has accumulated that aldosterone secretion is under endogenous dopaminergic inhibition. To examine potential sources of the dopamine thus inhibitorily acting in the adrenal zona glomerulosa, the responsiveness of aldosterone, plasma renin activity, prolactin, and plasma catecholamines to haloperidol, a dopaminergic antagonist, was studied in rats 6 weeks after unilateral adrenalectomy (Group B), 6 weeks after unilateral adrenal demedullation followed by contralateral adrenalectomy 5 days later (Group C), and in controls without any pretreatment (Group A). In Group C, there were increases in basal levels of norepinephrine (P less than 0.01), prolactin (P less than 0.02), and aldosterone (P less than 0.01). Basal plasma renin activity was also increased (P less than 0.05), epinephrine concentrations were decreased. Two hours after haloperidol 1 mg/kg b.wt. i.p., aldosterone levels were increased in Groups A + B (P less than 0.01) but unresponsive in Group C. Haloperidol-induced stimulation of prolactin and norepinephrine was not impaired by the surgical procedures. Epinephrine levels were increased by haloperidol only in groups A + B (P less than 0.002). In none of the groups were plasma renin activity or dopamine levels influenced by haloperidol. It is concluded that dopaminergic inhibition of aldosterone production is brought about neither by circulating dopamine nor by potential dopaminergic nerves accompanying arterial blood supply of the adrenal cortex but by dopamine originating directly in adrenal medulla.

Adrenal Medulla↗
PubMed1986

Microcirculation in muscle.

The microvascular architecture in muscle is reviewed herein. The intrinsic vasculature is similar in different muscles. There are numerous arterioarterial (100 microns diameter) and venovenous (150 microns) anastomoses creating a large microscopical network. End-arterioles (30 microns), end-venules (50 microns), and capillaries (6 microns) form a smaller microscopical network. There are no arteriovenous shunts. Precapillary arterial vessels larger than 10 microns have one or several layers of smooth muscle cells. There are no precapillary sphincters. Postcapillary vessels larger than 15 microns have one continuous layer of smooth muscle cells. Calculations show that the cross-sectional area is the smallest and hence resistance the greatest in arterioles of 22 microns and venules of 40 microns. There is better physiological support for giving plasma expanders, such as dextran, rather than vasodilators in low flow situations.

Animals↗