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Biomedical subjects

G Giagnoni

Publications and source records attributed to G Giagnoni.

45 records · Page 3Linked to original sources
PubMed1978

Changes in liver tyrosine aminotransferase after acute and chronic administration of morphine in the rat.

Acute administration of Morphine (20 mg/kg/s.c.) in the rat results in a rise of liver tyrosine aminotransferase (TAT) expressed as mumoles of p-hydroxyphenylpyruvate/100 mg/h. With chronic administration, a tolerance develops to this enzymatic effect. TAT induction is not evident in pregnant rats, given the narcotic, in which enzyme levels are already initially high. After delivery TAT returns to normal levels and it is possible to show both induction and tolerance developing to morphine. Enzyme activity in fetal livers is much lower than that of adult animals: after maternal administration of morphine only a modest TAT increase is seen which is not, however, statistically significant. TAT activity is fully evident in livers of offspring, with much higher mean levels in newborn rats from morphine-treated animals, as a possible consequence of morphine deprivation. In this latter group of newborn rats narcotic administration causes TAT activity to return to levels as high as those of naive animals. On the other hand, morphine administration to the prole of naive rats results in an induction of liver TAT.

Animals↗
PubMed1977

Synthesis of opiate peptides by a clonal pituitary tumor cell line.

Clonal mouse pituitary tumor cells, AtT-20, synthesize at least four species of peptides with opiate activity. The endorphin concentration of AtT-20 cells was estimated to be 300-600 pmol/mg of protein. The two most abundant endorphins with apparent molecular weights of 1800 and 2400 were purified 300- and 24-fold, respectively; additional minor components were found with apparent molecular weights of greater than 3000 and less than 750.

Adenylyl Cyclases↗
PubMed1976

Serum corticosterone as a quantitative test of the phlogistic potency of various agents topically applied in the rat.

The application into the rat conjunctiva of various phlogistic agents, such as croton oil, mustard oil and formaldehyde, elicits an increase of serum corticosterone linearly related to the log of the applied concentrations, so that from their parallelized regression lines it is possible to calculate the phlogistic potency of each tested agent in reference to croton oil. The time kinetic of such an increase (elicited by croton oil) is compared with that of two other parameters previously adopted as indirect quantitative indices of the phlogosis: the adrenal ascorbic acid depletion and the liver tyrosine-alpha-ketoglutarate transaminase increase. Serum corticosterone is shown to be the quickest and the most sensitive of the adopted indices, even if the phlogistic potency of the tested agents and the precision of these evaluations substantially coincides whatsoever the index adopted. Finally the pathways of adrenocortical activation are investigated and it is shown that the activation may be peripherally blocked by topical application of corticosteroids (but not of local anesthetics) and centrally by hypophysectomy or parenteral administration of pentobarbital plus morphine.

Administration, Topical↗
PubMed1975

[Parenteral feeding in resuscitation. Study of 190 cases].

Results observed in 190 patients receiving parenteral nutrition (including 104 thus treated for periods of 3 to 28 days) are presented. The data point to the importance of both the quantity and quality of the calorie and nitrogen intake. The energy and plastic sources used in the treatment are discussed. The modalities most suited for employment in patients with unimpaired renal functional and in those with serious renal insufficiency are described in the light of personal experience.

Acute Kidney Injury↗