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Biomedical subjects

G Gissel-Nielsen

Publications and source records attributed to G Gissel-Nielsen.

11 recordsLinked to original sources
PubMed1993

Differences in the sensitivity of barley varieties to direct cesium contamination from the Chernobyl accident.

A number of winter and spring barley (Hordeum vulgare L) varieties were tested for sensitivity to direct cesium contamination in Denmark arising from the Chernobyl accident. Significant differences among varieties were revealed which were independent of crop growing conditions. Results indicate that different sensitivities among varieties result from genetic or morphological differences.

Accidents↗
PubMed1986

Selenium fertilizers and foliar application, Danish experiments.

In 1963 Se-deficiency was observed for the first time in Denmark in a few sheep in West Jutland. The sheep were cured by injection of "Tokosel", and a survey of the Se-status of Danish fodder crops was initiated. A comprehensive set of data was produced during the early 70's, using the fluorometric method. The survey showed a general Se-deficiency in the whole country, and series of experiments were carried out to elucidate the possibility of raising the selenium level in plants from the native 0.02-0.04 ppm to more than the desired minimum of 0.05 ppm. Three different methods of application were tested: seed pretreatment, fertilizer enrichment, and foliar application. Seed pre-treatment has some disadvantages while the two other methods proved to be efficient and safe in a series of experiments and in tests on a large number of farms all over Denmark. These experiments and tests are discussed in detail. It is concluded that about 120 g Se/ha as sodium selenite, 10 g Se/ha as sodium selenate - both added through PK- or NPK-fertilizers, or foliar application of about 5 g Se/ha are sufficient yearly treatments to raise the native Se content of the Danish crops to levels of 0.05-0.1 ppm.

Animals↗
PubMed1980

Leucocyte glutathione peroxidase activity and selenium level in multiple sclerosis.

In continuation of our previous studies, which demonstrated a decreased glutathione peroxidase (GSH-Px) activity of erythrocytes from multiple sclerosis (MS) patients the activity of some enzymes regulating the peroxide level (GSH-PX and glutathione reductase (GSSG-Rd)) in leucocytes and erythrocytes respectively, the selenium level of whole blood and the beta-glucuronidase activity of serum (marker of lysosomal membrane damage) were assayed in this group of patients. GSH-Px activity in lymphocytes and granulocytes from MS patients was significantly (2 alpha smaller than or equal to 0.01) decreased by 35-50%. Erythrocyte glutathione reductase activity was only insignificantly decreased in MS patients. Erythrocyte GSH-Px : GSSG-Rd ratio was 11.0 for the control group, but 8.0 for the MS group. The selenium content of whole blood and serum from Danish MS patients was normal. The selenium level in erythrocytes from Danish MS patients was however higher than the selenium level in erythrocytes from controls.

Erythrocytes↗
PubMed1978

Biochemical abnormalities in Batten's syndrome.

The present data indicate that a group of ten patients with Batten's syndrome showed reduced activity of erythrocyte glutathione (GSH) peroxidase (Px) (glutathione: H2O2 oxidoreductase, EC 1.1.1.9.) using H2O2 as peroxide donor. Assay of erythrocyte GSHPx using H2O2, cumene hydroperoxide and t-butyl hydroperoxide as donors also makes it possible biochemically to divide Batten's syndrome into two types: (1) one type with decreased values when H2O2 and cumene hydroperoxide are used, and (2) one type with increased values when t-butyl hydroperoxide is used. Furthermore an increased content of palmitic, oleic and of eicosatrienoic acid but decreased linoleic acid content was found in serum from patients with Batten syndrome. An inverse relationship between erythrocyte GSHPx and serum eicosatrienoic acid was found in the patients. Finally normal selenium levels were found in erythrocytes, but decreased values were traced in whole blood. In normal human beings a connection was found between the erythrocyte selenium content and GSHPx activity assayed by cumene hydroperoxide as a peroxide donor.

Adolescent↗