PubMed Health⌕ Search

Biomedical subjects

G Glass

Publications and source records attributed to G Glass.

At least 19 recordsLinked to original sources
PubMed2002

Geographic epidemiology of gonorrhoea and chlamydia on a large military installation: application of a GIS system.

OBJECTIVES: The geographic epidemiology of infectious diseases can help in identifying point source outbreaks, elucidating dispersion patterns, and giving direction to control strategies. We sought to establish a geographic information system (GIS) infectious disease surveillance system at a large US military post (Fort Bragg, North Carolina) using STDs as the initial outcome for the model. METHODS: Addresses of incident cases were plotted onto digitised base maps of Fort Bragg (for on-post addresses) and surrounding Cumberland County, NC (for off-post addresses) using MAPINFO Version 5. We defined 26 geographic sectors on the installation. Active duty soldiers attending the post preventive medicine clinic were enrolled between July 1998 and June 1999. RESULTS: Gonorrhoea (GC) was diagnosed in 210/2854 (7.4%) and chlamydia (CT) in 445/2860 (15.6%). African-American male soldiers were at higher risk for GC (OR = 4.6 (95% CL 3.0 to 7.2)) and chlamydia (OR = 2.0 (1.4 to 2.7)). For women, there were no ethnic differences in gonorrhoea prevalence, but chlamydia was higher in African-Americans (OR = 2.0 (1.4-2.7)). Rank and housing type were associated with gonorrhoea and chlamydia in men, but were not significant factors in women. For gonorrhoea, two geographic sectors had prevalences between 14.0%-16.5%, three between 10.3%-13.9%, three between 7.1%-10.2%, and five between 3.0%-7.1%. The geographic distribution demonstrated a core-like pattern where the highest sectors were contiguous and were sectors containing barracks housing lower enlisted grade personnel. In contrast, chlamydia prevalence was narrowly distributed. CONCLUSION: GIS based disease surveillance was easily and rapidly implemented in this setting and should be useful in developing preventive interventions.

Chlamydia Infections↗
PubMed2000

Pathway for the strain-driven two-dimensional to three-dimensional transition during growth of Ge on Si(001)

The two-dimensional (2D) to three-dimensional (3D) morphological transition in strained Ge layers grown on Si(001) is investigated using scanning tunneling microscopy. The initial step takes place via the formation of 2D islands which evolve into small ( approximately 180 A) 3D islands with a height to base diameter ratio of approximately 0.04, much smaller than the 0.1 aspect ratio of 105-faceted pyramids which had previously been assumed to be the initial 3D islands. The "prepyramid" Ge islands have rounded bases with steps oriented along <110> and exist only over a narrow range of Ge coverages, 3.5-3.9 monolayers.

Journal Article↗
PubMed1999

Reducing dust, lead, dust mites, bacteria, and fungi in carpets by vacuuming

Old carpets may be reservoirs of dust, lead (Pb), and dust mite allergen. The purpose of this study was to determine if the dust, Pb, dust mite allergen, bacteria, and fungi on the surface of carpets could be reduced by 90% in 1 week with the use of a Hoover Self Propelled Vacuum with Embedded Dirt Finder (HSPF). A high-volume surface sampler (HVS3) was used to measure surface dust and pollutants before and after the use of the HSPF to remove deep dust in carpets 12 to 20 years old in nine middle-class homes and two small offices. The minimum, median, and maximum surface loading for the first and final samples are as follows: first fine dust loading: min 0.32 g/m2, max 14.4 g/m2, median 1.30 g/m2; final fine dust loading: min 0.019 g/m2, max 0.289 g/m2, median 0.102 g/m2; first Pb loading: min 38 &mgr;g/m2, max 3,871 &mgr;g/m2, median 471 &mgr;g/m2; final Pb loading: min 13 &mgr;g/m2, max 2,023 &mgr;g/m2, median 86 &mgr;g/m2; first mite loading: min 0.11 &mgr;g/m2, max 12. 88 &mgr;g/m2, median 2.82 &mgr;g/m2; final mite loading: min 0.06 &mgr;g/m2, max 3.67 &mgr;g/m2, median 0.28 &mgr;g/m2. Data were insufficient to determine if the loadings of bacteria and fungi were reduced a similar amount. Six to 45 min/m2 of vacuuming with the HSPF removed deep dust from these carpets. The median surface loadings of fine dust, Pb, and dust mite allergen in these 11 carpets were reduced by 91, 82, and 94%, respectively, in 1 to 15 h of vacuuming. The loading of the deep dust collected with the HSPF ranged from 8 to 171 g/m2 with a median of 66 g/m2.

Journal Article↗
PubMed1999

The geography of sexual partnerships in Baltimore: applications of core theory dynamics using a geographic information system.

OBJECTIVE: Gonorrhea has a focused geographic distribution characterized by high incidence rates in defined "core" areas and decreased incidence as the radial distance from the central core increases. Dense cor group transmission has long been hypothesized. METHODS: We have previously mapped sexually transmitted disease (STD) rates in Baltimore census tracts using STD morbidity data interfaced with a geographic information system. Core areas were defined using a standard definition based on gonorrhea distribution. We studied spatial distance patterns between sexual partners, using the residential addresses of 572 individuals, representing 286 dyad partnerships recruited as part of an epidemiology and behavioral study. To determine if partners lived closer together than would be expected, a modified bootstrap algorithm using Monte Carlo models was developed to compare the distances between partners' residences and all other possible residences. RESULTS: Two distinct (east and west) core areas were previously identified. Compared with randomly selected Baltimore addresses, partners tended to reside closer to one another than would be expected by chance (z = -1.8), with a median distance of 1.7 kilometers. Within the core areas, women resided a median of 547 meters from their partner, and men resided a median of 339 meters from their reported partners. When all partnerships were considered, the median distance was 1,699 meters. Of the 500 simulation models, the minimum median distance was 4,889 meters. CONCLUSIONS: Partners of patients in core areas in Baltimore live remarkably close to one another, and the partner selection patterns in general indicate nonrandom distribution. Geographic information system-determined patterns of STD patients residing in hyperendemic census tracts support the core theory of disease transmission. In these areas, targeted geographically based interventions may be warranted.

Adult↗
PubMed1995

Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida.

Numerous rodents were trapped for serologic and virologic studies following the identification of a hantavirus pulmonary syndrome (HPS) case in Dade County, Florida. Cotton rats (Sigmodon hispidus) were the most frequently capture rodent and displayed the highest seroprevalence to a variety of hantavirus antigens. Hantavirus genome RNA was detected in all the seropositive cotton rats tested, using a reverse transcriptase-polymerase chain reaction (RT-PCR) assay. A virus was isolated from tissues of two seropositive cotton rats by cultivation of lung and spleen homogenates on Vero E6 cells. Nucleotide sequence information obtained by direct RT-PCR and the serologic relationships of this virus with the other hantaviruses indicate that this virus, Black Creek Canal virus, represents a new hantavirus distinct from the previously known serotypes.

Animals↗
PubMed1994

The effects of antioxidants and enzymes involved in glutathione metabolism on mutagenesis by glutathione and L-cysteine.

The effects of small molecular weight antioxidants and antioxidant enzymes on the mutagenicities of glutathione (GSH) and L-cysteine were studied in Salmonella typhimurium strain TA102. GSH and cysteine mutagenesis were inhibited by antioxidants and radical scavengers such as alpha-tocopherol, Trolox C, butylated hydroxyanisole (BHA), and retinyl acetate. Superoxide dismutase (SOD) had no effect, but catalase and horseradish peroxidase (HRP) inhibited mutagenesis. The heat-denatured enzymes had no effect on mutagenesis. Cysteine mutagenesis was enhanced by native and by heat-denatured rat-kidney post-mitochondrial supernatant, and by ferric ions. H2O2 and the H2O2-generating system of glucose-glucose oxidase (GOX) were mutagenic in TA102. Synergistic increases in mutagenesis were obtained in systems containing combinations of GSH or cysteine, with either H2O2 or the H2O2-generating system of glucose-GOX. GSH peroxidase (GPX) had no effect on mutagenesis of GSH or of H2O2, whereas the synergistic increase in mutagenesis by a combination of GSH and H2O2 was effectively inhibited by GPX. The results suggest strongly that, at least in biochemically-defined systems, GSH and cysteine mutagenesis are oxidative in nature, and involve reactive forms of oxygen and/or other radicals.

Animals↗
PubMed1993

Airway area by acoustic reflection: the two-microphone method.

This report deals with noninvasive imaging of airway geometry based upon information contained in acoustic reflections measured at the mouth. Here we describe a new theoretical approach that enables development of a new miniaturized apparatus. Unlike the single-transducer systems used currently, this new strategy is based upon a two-transducer system that is a variant of that suggested originally by Shroeder (1967). We have developed, implemented, and tested computational algorithms necessary to reconstruct airway dimensions from acoustic reflection data using this two-transducer strategy.

Acoustics↗